A Asilian; Z Nilforooshan
Volume 5, Issue 2 , 2002, , Pages 3-10
Abstract
Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin ...
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Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin disorders was compared to placebo. Patients and Methods: In a controlled clinical trial, 40 patients (21 patients with post-herpetic neuralgia, 10 with lichen simplex chronicus, and 9 with notalgia paresthetica), with the mean age of 48 years were randomly treated with 0.075% capsaicin gel or placebo q.i.d. for 4 weeks. The severity of symptoms and side effects were assessed every two weeks and recurrence was assessed also two months after treatment. Results: 31 cases (77%) completed their 4 weeks treatment period. According to visual Analogue Score system, the mean of symptom severity decreased from 7.6 (±2.4) before treatment to 0.9 (±0.9) after treatment in capsaicin group and decreased from 6.3 (±2.3) to 5.0 (±3.2) in placebo group (P<0.05). Conclusion: Capsaicin gel is effective in painful and pruritic skin disorders and has tolerable side effects.
H Mortazavi; A Khamesipour; Z Hallaji; H Bakhshi; A Miramin Mohammadi
Volume 5, Issue 4 , 2002, , Pages 3-9
Abstract
Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) ...
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Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) and Leishmanin skin test (LST) between non-healing and healed patients of CL. Patients and Methods: Fifteen patients with non-healing CL suffering for more than two years, and eight individuals cured from CL were enrolled in this study. The rate of IFN-γ production by peripheral blood mononuclear cells assessed by ELISA and results of LST were compared in both groups. Results: The mean level of the IFN-γ production in non-healing patients and cured individuals were 729 pg/ml, and 4229 pg/ml, respectively (T- test, P<0.01). Four patients in non-healing group had negative LST and all cured patients had positive LST. Conclusion: The low level of the IFN-γ in non-healing patients and high level of IFN-γ in healed individuals are in favour of the lack of TH1 response, which is usually seen in healed patients. Comparing the results of LST between two groups is not conclusive.
S Family
Volume 5, Issue 1 , 2001, , Pages 3-8
Abstract
Background: Psoriasis is a common disease of the skin. Metabolic disorders have been suggested in the etiology of psoriasis. Objective: As hypocalcemia has been reported to provoke psoriasis, we studied the blood calcium level in this disease. Patients and Methods: In this case-control study, we measured ...
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Background: Psoriasis is a common disease of the skin. Metabolic disorders have been suggested in the etiology of psoriasis. Objective: As hypocalcemia has been reported to provoke psoriasis, we studied the blood calcium level in this disease. Patients and Methods: In this case-control study, we measured blood calcium level in 120 psoriatic patients visited in outpatient clinic or admitted in Ghahem Hospital in Mashhad and compared to 120 age and sex matched normal controls. Results: Considering blood calcium level of 8.5-10.5 mg/dl as normal, 17 psoriatic patients (14%) and 6 controls (5%) were hypocalcemic (P<0.05). Conclusion: As hypocalcemia in psoriatic patients was significantly more common in this study, estimation of blood calcium level is recommended in psoriasis.
M Shahidi Dadras; H Naseh Ghafoori; L Gachkar
Volume 6, Issue 4 , 2003, , Pages 3-10
Abstract
Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. ...
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Background: The current treatments of recurrent aphthous stomatitis are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical sucralfate mouthwash with topical tetracycline mouthwash in recurrent aphthous stomatitis. Patients and Methods: In a randomized matched clinical trial, 60 patients with recurrent aphthous stomatitis fulfilling our inclusion criteria, referred to skin clinics affiliated to Skin Research Center in Shahid Beheshti University of Medical Sciences in 1380-81 were assessed. The patients were randomly divided in two groups, matched for age and type of the ulcer. The case group (26 patients) used a mouthwash containing 1gr sucralfate per 15cc, and the control group (34 patients) used a mouthwash containing 250mg tetracycline per 15cc, four times a day and were assessed every 2 weeks. The data were analyzed by chi-square and t-tests (P<0.05). Results: There were no significant difference between two groups regarding the frequency, healing time and pain of the aphthous lesions. Patients were more satisfied with the sucralfate suspension than tetracycline suspension in the end of treatment period (P<0.03) and in the end of follow up period (P<0.04). No side effects were seen in two group. Conclusion: Sucralfate suspension mouthwash can be considered equally effective as tetracycline mouthwash in treating recurrent aphthous stomatitis. It can be considered as a special modality for aphthous ulcer treatment due to lack of systemic toxicity and side effects even if accidentally swallowed or absorbed through mucosal surfaces.
S Emmet
Volume 1, Issue 2 , 1998, , Pages 4-8
H Pourmoghim; Gh.H Ghaffarpour; J Malboobi
Volume 6, Issue 3 , 2003, , Pages 4-7
Abstract
Background: The strong association of Behcet’s disease with HLA-B5 antigen has been observed in several ethnic groups from Middle East to Far East. Objective: To evaluate the frequency and association of HLA-B5 and also likelihood ratio of involvement in Behcet’s disease in a group of Iranian ...
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Background: The strong association of Behcet’s disease with HLA-B5 antigen has been observed in several ethnic groups from Middle East to Far East. Objective: To evaluate the frequency and association of HLA-B5 and also likelihood ratio of involvement in Behcet’s disease in a group of Iranian patients. Patients and Methods: HLA-B5 antigen typing was performed by serologic method in 56 patients with Behcet’s disease (Diagnosed by International Study Group Criteria) and 71 cases with seronegative diseases as control group. The difference in frequency and association between HLA-B5 antigen and Behcet’s disease was evaluated by chi-square test and phi-test. Results: The phenotype frequencies of HLA-B5 antigen in Behcet’s disease patients and control group were 66% and 26% respectively (X=19.62, P=0.0001). The association of HLA-B5 antigen phenotype with Behcet’s disease was strong (Phi=0.39, P=0.0001). The likelihood ratio was 20:1 for HLA-B5 antigen positivity and Behcet’s disease. Gene frequency of HLA-B5 was 46% in Behcet’s disease patients and 14% in control group. Conclusion: This study revealed a strong association of HLA-B5 antigen with Behcet’s disease in Iranian patients.
H Ansarin
Volume 1, Issue 1 , 1997, , Pages 5-9
Abstract
Warts are among the most common skin diseases especially in children between the ages of 12-16 years. Usually plantar and periungual lesions are resistant to traditional treatments and cause a lot of trouble for patients. The aim of this study was to evaluate therapeutic effects of intralesional Bleomycin ...
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Warts are among the most common skin diseases especially in children between the ages of 12-16 years. Usually plantar and periungual lesions are resistant to traditional treatments and cause a lot of trouble for patients. The aim of this study was to evaluate therapeutic effects of intralesional Bleomycin injection. This study was performed on 38 cases of recalcitrant warts. All the lesions disappeared by one or two injections during 1-2 months. After one-year follow-up, recurrence was observed in two cases.
J Gholchye; H Shojaei Tehrani
Volume 3, Issue 1 , 1999, , Pages 5-10
Abstract
Background: Leprosy is a chronic infectious disease endemic in some areas of Gilan province. Objective: To evaluate the knowledge of the personnel employed in Health System Network (Including Behvarzes, Kardans and physicians) on leprosy. Materials and Methods: Questionnaires consisting of 14 multiple ...
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Background: Leprosy is a chronic infectious disease endemic in some areas of Gilan province. Objective: To evaluate the knowledge of the personnel employed in Health System Network (Including Behvarzes, Kardans and physicians) on leprosy. Materials and Methods: Questionnaires consisting of 14 multiple choice questions for Behvarzes and 20 multiple choice questions for Kardans and physicians wee given to 268, Behvarzes 32 Kardans and 27 physicians employed in 4 areas of Gilan province (Roodsar, Rasht, Fooman and Roodbar). The questions included various aspects of leprosy. Results: 72.4% of Behvarzes scored excellent or good for the questions regarding the clinical features and epidemiology of leprosy. But the percentage of correct responses for Kardans and physicians were not satisfactory. Conclusion: The knowledge of Behvarzes about leprosy is enough for the integration of the program of elimination of leprosy in the Health System Network, at least in Gilan province. But further training for Kardans and physicians seems mandatory.
L Dastgheib; A Alborzi; F Djokar; B Abudi; M Kalani
Volume 6, Issue 1 , 2002, , Pages 5-9
Abstract
Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. ...
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Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. Patients and Methods: Sampling was done on lesions of 123 patients with acne vulgaris who referred to dermatology clinic of Shahid Dr. Faghihi hospital in Shiraz. After isolation and confirmation of P.acne minimal inhibitory concentration (MIC) of above-mentioned antibiotics were measured with agar dilution test. Results: From 123 patients, 129 samples were taken. Presence of P.acnes was confirmed in 62 samples. MICs for antibiotics were: Tetracycline 0.03-0.125 µg/ml, erythromycin 0.015-0.06 µg/ml, clindamycin 0.03-0.5 µg/ml and spiramycin 0.015-0.25 µg/ml. Conclusion: The samples of P.acnes isolated from acne vulgaris lesions in this study were sensitive to above mentioned antibiotics.
MJ Nazemi; S Sotoodeh; H Moslehi
Volume 6, Issue 2 , 2003, , Pages 5-13
Abstract
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The ...
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Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referred to Razi Hospital in Tehran in 1377 were recorded in special questionnaires. Data were analyzed by SPSS software, T-Student and chi-square tests were used. Results: The number of female patients was twice of males, majority in the age range of 20 to 50 years, Most of the patients had no complaints except for skin eruptions. Paraclinical abnormalities were rare. The paraclinical changes were various, but hydropic degeneration of basal layer was found in all cases. Conclusion: Complementary studies are suggested to evaluate similarities and differences in Iranian and non-Iranian patients with DLE.
S Shamsaddini; A Bahrampour; S Soltani
Volume 2, Issue 4 , 1999, , Pages 5-11
Abstract
Introduction: Stereotypic behaviors are characterized by repetitive, deviated and aimless actions that persist for more than 4 months in individual. Nail biting habit is one of informed obsessive-compulsive disorders that begins in childhood and continues for a long time. Onychophagia is a disorder with ...
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Introduction: Stereotypic behaviors are characterized by repetitive, deviated and aimless actions that persist for more than 4 months in individual. Nail biting habit is one of informed obsessive-compulsive disorders that begins in childhood and continues for a long time. Onychophagia is a disorder with unknown cause and many factors can predispose it in a child. Individual characteristics and environmental factors are among other factors that may cause onychophagia in a child. Materials and Methods: In this cross sectional study prevalence of nail biting in 600 male and female students of primary schools of Kerman has been assessed. Results: The prevalence of nail biting was 28.7% and the duration of onychophagia was between 1-2 years in 53.5% of cases. Onychophagia was most common in age group of 13 years. IQ, grade, success in exams, parents job and association with other stereotypic habits were evaluated. Nutrition in infancy period, position of labor, parents’ educational level, and family population were also analyzed. No significant relation was found between any of above factors and nail biting. Conclusion: Nail biting can be considered as an independent and temporary event in the growth period of child.
S Shamsi Meymandi; Sh Dabiri; F Soleimani
Volume 2, Issue 1 , 1998, , Pages 7-12
Abstract
Many investigators believe that immunotherapy will be the only selected treatment for leishmaniasis in the future. Leishmanization, vaccination or injection of stimulating mediators are among various forms of immunotherapy. In this pilot study, 5 volunteers with cutaneous leishmaniasis due to L.tropica ...
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Many investigators believe that immunotherapy will be the only selected treatment for leishmaniasis in the future. Leishmanization, vaccination or injection of stimulating mediators are among various forms of immunotherapy. In this pilot study, 5 volunteers with cutaneous leishmaniasis due to L.tropica were treated with 4 weekly intralesional injections of autologous buffy coat. Cytological and histopathological changes showed the importance of the infiltration of neutrophils and lymphocytes and cytoplasmic degenerative changes in macrophages containing the parasite and cellular necrosis in destroying the parasites. These were correlated with clinical improvement and reduction in size of erythema and induration.
M Bani Hashemi; R Daneshmandrokhi
Volume 2, Issue 3 , 1999, , Pages 7-14
Abstract
In several reports a close relationship between lichen planus and chronic viral hepatitis has been demonstrated. According to the high prevalence of hepatitis B in communities like Iran and especially in Sistan-va-Baloochestan, a prospective study was performed for screening HBV markers in patients suffering ...
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In several reports a close relationship between lichen planus and chronic viral hepatitis has been demonstrated. According to the high prevalence of hepatitis B in communities like Iran and especially in Sistan-va-Baloochestan, a prospective study was performed for screening HBV markers in patients suffering lichen planus to detect the prevalence of HBsAg positive cases in them, comparing with general population, i.e. 4%. On the other hand we decided to detect some groups of lichen planus patients that this ratio mat be more in them. On this basis, 80 patients were studied during 9 months. 8 cases (10%) were HBsAg positive, showing significant increase comparing to the general population (4%). Also, the prevalence of HBsAg positive cases was greatly more in patients who had oral mucosal membrane involvement (41.2% of all patients).
SH Hejazi; P Nasrifar; S Jamali; AA Jahangir Nezhad; A Khamesipour
Volume 4, Issue 1 , 2000, , Pages 7-11
Abstract
Background: Isfahan is one of the major foci of cutaneous leishmaniasis in Iran. According to the epidemiological studies, both urban and rural forms have been reported in Isfahan. Accurate identification and characterization of Leishmania is essential for the control of the disease. Several different ...
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Background: Isfahan is one of the major foci of cutaneous leishmaniasis in Iran. According to the epidemiological studies, both urban and rural forms have been reported in Isfahan. Accurate identification and characterization of Leishmania is essential for the control of the disease. Several different molecular techniques for Leishmania identification are developed including use of monoclonal antibodies. Objective: In the present study specific monoclonal antibodies against L.major (T1, T9), L.tropica (T10, T11) and L.donovani (D2) were used to identify and characterize the leishmania parasites isolated from patients with cutaneous leishmaniasis in Isfahan. Patients and Methods: Samples were obtained from borders of lesions suspicious of leishmaniasis in 298 patients, stained with Giemsa and cultured in NNN and RPMI 1640 media supplemented with 10% fetal colf serum. The promastigotes were then purified, counted and used as antigen in ELISA test. Results: Mass production of promastigotes was successful in 120 cases. L.major was identified as the causative agent of the disease in 100 cases and L.tropica in 8 patients. In 12 cases the results were inconclusive as the antigens reacted with either 2 or 3 specific monoclonal antibodies. Conclusion: L.major is the most common cause of leishmaniasis in Isfahan.
P Toosi; F Malekzad; A Sedigha
Volume 8, Issue 1 , 2004, , Pages 7-14
Abstract
Background: The theory of selective photo-thermolysis led to the development of a variety of different laser systems which range from the shorter spectrum of 694nm ruby laser to the middle with the 755nm alexandrite and 810nm diode lasers to the long end with the 1064nm (Nd:YAG) laser. Objective: A systematic ...
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Background: The theory of selective photo-thermolysis led to the development of a variety of different laser systems which range from the shorter spectrum of 694nm ruby laser to the middle with the 755nm alexandrite and 810nm diode lasers to the long end with the 1064nm (Nd:YAG) laser. Objective: A systematic review on the clinical trials with use of various laser sources for hair removal. Methods: All clinical trials related to hair removal lasers in 1998-2003 were selected. After elimination of heterogenicity sources in data, results were synthesized on the basis of laser type and were compared using ANOVA and t tests, P
A Yazdanfar; K Karimirad; Kh Mani Kashani
Volume 7, Issue 1 , 2003, , Pages 8-13
Abstract
Background: Wart is a common skin disease, and 8% of patients referred to dermatologists suffer from warts. Objective: To compare the efficacy of intralesional injections of bleomycin with normal saline in treatment of common resistant warts on palms and dorsum of hands. Patients & Methods: This ...
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Background: Wart is a common skin disease, and 8% of patients referred to dermatologists suffer from warts. Objective: To compare the efficacy of intralesional injections of bleomycin with normal saline in treatment of common resistant warts on palms and dorsum of hands. Patients & Methods: This study was a double blind, randomized, controlled clinical trial on 34 patients with common warts on palms and dorsum of their hands. These patients were randomly divided into two groups: 18 patients were treated with intralesional injections of bleomycin and 16 patients were treated with intralesional injections of normal saline. After 3 weeks of treatment, patients were evaluated and in case of unresponsiveness the second injection with the same medication was attempted. This group was visited again 3 weeks later and finally response to treatment ad possible complications were evaluated. Results: In bleomycin group 88.9% and in normal saline group 56.3% remitted (Fisher’s exact test, P<0.05). Conclusion: Intralesional bleomycin is an effective and low risk treatment of common resistant warts on palms and dorsum of hands.
R Yaghoobi; SJ Hashemi
Volume 2, Issue 2 , 1999, , Pages 10-19
Abstract
Helicobacter pylori is probably the commonest bacterial infection worldwide and is now accepted as the cause of gastritis, peptic ulcer, gastric carcinoma, and gastric lymphoma. In the last few years, besides the local gasteroduodenal tissue damage, an association between H.pylori and various extra-intestinal ...
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Helicobacter pylori is probably the commonest bacterial infection worldwide and is now accepted as the cause of gastritis, peptic ulcer, gastric carcinoma, and gastric lymphoma. In the last few years, besides the local gasteroduodenal tissue damage, an association between H.pylori and various extra-intestinal pathologies had been described. Recent studies have suggested that H.pylori infection may be associated with various skin disorders such as idiopathic chronic urticaria, Raynaud’s phenomenon, systemic sclerosis, rosacea, Sweet’s syndrome, Henoch-Schonlein purpura, psoriasis, and atopic dermatitis. In this paper we review the current knowledge on Helicobacter pylori infection and its relevance for skin diseases especially its clinical pathophysiological aspects.
M Eslami Danesh Pajooh; F Jafari; M Farivar Sadri; M Valikhani
Volume 3, Issue 2 , 2000, , Pages 10-15
Abstract
Background: Oral ivermectin is recently introduced for the treatment of scabies. Objective: The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and Methods: Fifty-eight cases ...
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Background: Oral ivermectin is recently introduced for the treatment of scabies. Objective: The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and Methods: Fifty-eight cases were randomly assigned in the two treatment groups. In the ivermectin group, patients received a single oral dose of the drug (200 µg/kg). In the case of any signs of active disease, a second dose was administered one week later. All the patients in the GBH group received two topical applications of the drug, one week apart. The patients were seen after 48 hours, 1, 2, and 4 weeks. Results: Of the 37 patients treated with ivermectin, 27 (73%) showed clinical cure with a single dose and 10 (27%) required a second dose one week later. In the 21 patients treated with GBH, 18 (85.7%) received two applications of GBH, and three cases (14.3%) were cured by an additional curse of precipitated sulfur 6%. No serious side effects were seen in either group. The mean time for the drop of pruritus, the sense of well being and the healing of lesions, were each shorter with ivermectin than GBH, and the differences were statistically significant. Conclusion: Although all of the patients treated with ivermectin or topical GBH were cured, ivermectin cured faster than topical treatment.
H Tabatabai; Z Haji Abbasi
Volume 1, 3-4 , 1998, , Pages 12-22
Abstract
Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders ...
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Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clinical uses of thalidomide in the treatment of dermatologic diseases was performed. Diseases for which thalidomide has been found effective include erythema nodosum leprosum, prurigo nodularis, actinic prurigo, discoid lupus erythematosus, aphthous stomatitis, Behcet’s syndrome, and graft versus-host disease. Side effects such as teratogenicity and peripheral neuropathy remain its limiting factors. Thalidomide is a useful addition to the therapeutic armamentarium for treatment-resistant dermatoses as long as proper vigilance for adverse effects is maintained.
Farhad Handjani; Nasrin Saki; Sona Zandi; Mohammad Sadegh Sayyafan; Bahareh Kardeh; Yasaman Emami; Alireza Heiran
Volume 19, Issue 1 , 2016, , Pages 14-5
Abstract
Background: Wart is a common skin disease that can occur at any age. While they are usually benign and self-limited, they can become irritating and cosmetically disabling to patients. The objective of this study is to compare the effectiveness of a topical 85% formic acid preparation with a combination ...
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Background: Wart is a common skin disease that can occur at any age. While they are usually benign and self-limited, they can become irritating and cosmetically disabling to patients. The objective of this study is to compare the effectiveness of a topical 85% formic acid preparation with a combination of topical salicylic acid and lactic acid.Methods: We enrolled 66 patients, 7-60 years of age, in this triple-blind study. Patients were randomly divided into 2 groups: group 1 received a topical 85% formic acid solution and group 2 received DuoFilm (topical 16.7% salicylic acid + 16.7% lactic acid). The duration of treatment was a maximum of 4 weeks and we followed the patients every two weeks.Results: In group 1, 74.1% of the warts completely healed and 3.5% partially healed. In group 2 complete healing occurred in 40.8% and partial healing in 26.8% of the warts (P<0.001). Statistical analysis showed a significant difference in the favor of formic acid on the hands (P<0.001) but we did not observe a better effect for the feet. The time to complete healing was less for the majority of patients in the formic acid group (1 week versus 4 weeks). There were minimal adverse effects in each group, none that necessitated cessation of treatment.Conclusion: Topical formic acid had a higher cure rate for warts compared with a conventional preparation that consisted of both topical salicylic acid and lactic acid. This effect was particularly noted on the hands. This topical remedy could be regarded as an alternative to conventional treatments in the management of warts.
Balighi Kamran; Ghodsi Zahra; Iravani Masoud; Damavandi Maede Rayati; Goodarzi Azadeh; Lajevardi Vahide; Saburi Sara; Kashani Alireza Faghihi
Volume 19, Issue 75 , 2016, , Pages 21-24
Abstract
Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: ...
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Background: Chronic graft versus host disease (cGVHD) is a major cutaneous complication of bone marrow transplantation (BMT). Although milder forms of this process may be associated with a lower incidence of tumor recurrences, it is mandatory to develop a more efficient and less harmful therapeutic approach.Methods: This case-series study enrolled 7 patients diagnosed with chronic mucocutaneous GVHD. We divided the patients into three major categories based on the type of skin lesions: sclerodermoid, lichenoid, and mixed. Patients received several packs of narrow band UVB (NBUVB) phototherapy. Each pack contained ten sessions of NBUVB (311 nm) with a duration of at least ten seconds and a fixed radiation dosage (6 mj/cm2) during the treatment.Results: There were 3 patients diagnosed with lichenoid skin lesions, 2 with sclerodermoid lesions, and 2 had mixed cGVHD lesions. During the follow up period one patient was excluded due to a lower respiratory tract infection. The mean response ratio was 42% with a mean satisfaction level of 5.5 out of 10. The lichenoid group had the best, most rapid response. There were no serious adverse effects reported.Conclusion: Narrow band UVB phototherapy is useful as an adjuvant therapeutic modality in cutaneous lichenoid and intraoral cGVHD with no serious adverse effects.
EA Olsen; AG Messenger; J Shapiro; WF Bergfeld; MK Hordinsky; JL Roberts; D Stough; K Washenik; DA Whiting
Volume 8, Issue 2 , 2005, , Pages 32-46
Farajzadeh Saeedeh; Bazargan Nasrin; Shahesmaeili Armita; Shahrbabaki Azam Gholami; Fekri Ali Reza
Volume 13, Issue 2 , 2010, , Pages 33-36
Abstract
Background: The role of food allergy in atopic dermatitis (AD) is controversial. The aim of this study was to determine the frequency of food allergens in children with AD. Method: Fifty one atopic dermatitis children aged 6 months to 5 years entered our study. The severity of AD was determined by scoring ...
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Background: The role of food allergy in atopic dermatitis (AD) is controversial. The aim of this study was to determine the frequency of food allergens in children with AD. Method: Fifty one atopic dermatitis children aged 6 months to 5 years entered our study. The severity of AD was determined by scoring index of AD (SCORAD). Skin prick test (SPT) was done using 15 allergens including the white of the egg, yolk, peanut, kiwi, strawberry, cow's milk, walnut, fish, banana, wheat, orange, tomato, cereals, apple and cocoa. Results: Thirty four patients (66.7%) had a positive reaction to one or more allergens and in 17 patients (33.3%), the SPT was negative to all allergens. Eleven patients (21.6%) had a positive SPT to one food allergen, 9 patients (17.6%) to two allergens, 9 patients (17.6%) to three allergens, 3 patients (5.9%) to four allergens, 1 patient (2%) to seven allergens and 1 patient (%2) to ten allergens. The most common food allergen among 15 allergens was white egg in 19 patients (37.3%). Yolk was the second most common allergen in 11 patients (21.6%). The relationship between the severity of the SPT with AD severity was observed only for cow's milk, which showed a reverse relationship (R=-0.337). Conclusion: White egg was the most common allergen in all ages and both sexes. Food allergens may play a role in the pathogenesis of atopic dermatitis.
Esmaili Nafiseh; Chams-Davatchi Cheyda; Daneshpazhooh Maryam; Ghiasi Maryam; Abedini Robabe; Mortazavi Hossein; Roghani Iman
Volume 15, Issue 2 , 2012, , Pages 33-37
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune bullous disorder that is fatal if left untreated. High dose systemic corticosteroids are the basis of therapy. The addition of immunosuppressive agents has improved the disease outcome and reduced the required corticosteroid dose and related toxicity. ...
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Background: Pemphigus vulgaris (PV) is an autoimmune bullous disorder that is fatal if left untreated. High dose systemic corticosteroids are the basis of therapy. The addition of immunosuppressive agents has improved the disease outcome and reduced the required corticosteroid dose and related toxicity. Mycophenolate mofetil is increasingly used as a steroid-sparing agent in immunotherapy of PV. Herein, we tried to appraise the efficacy of mycophenolate mofetil and topical clobetasol in the control of the major relapses of pemphigus vulgaris. Method: Seventeen patients with severe relapse of pemphigus vulgaris were included in this study. All patients had complete remission on/off therapy before this period of recurrence. The patients were treated with 2g/day mycophenolate mofetil and 25-35g/day topical clobetasol propionate ointment. All patients were monitored for the side effects of therapy. Result: The patients were followed for a mean period of 12.7 months. The average length of time from initiating mycophenolate to 50% control (partial remission), which occurred in all patients, was 6±1.17 weeks. Fifteen patients achieved complete remission averagely at week 20.8±7.70. The average duration of followup after complete disease control was 8 months (ranging from 2-13.5 months). Three patients were free of lesions for more than 12 months and 10 for more than 6 months. No important mycophenolate mofetil related complication was observed during treatment. Conclusion: The combination of mycophenolate mofetil and topical corticosteroid can be used to control PV relapses and taper-off corticosteroid.
Firooz Alireza; Handjani Farhad; Lajevardi Vahideh; Mansouri Parvin; Nassiri-Kashani Mansour; Norouzi Yasaman
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria. Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2015. The current guideline is an update to the previous one and includes findings related to this subject which has been published in the medical literature from 2015 to August 2018.