Abbas Rasi; Leyla Tajziehchi; Nasrin Shayanfar
Volume 9, suppl.1 , 2006, , Pages 2-2
Abstract
Distant metastases are rare during the course of ovarian carcinoma. Ovarian epithelial adenocarcinomas rarely metastasize to the skin which is seen in less than 4% of patients. It usually presents as subcutaneous nodules and, less commonly, as inflammatory metastases which mimic cellulitis or viral or ...
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Distant metastases are rare during the course of ovarian carcinoma. Ovarian epithelial adenocarcinomas rarely metastasize to the skin which is seen in less than 4% of patients. It usually presents as subcutaneous nodules and, less commonly, as inflammatory metastases which mimic cellulitis or viral or bacterial skin infections. The histology in most of the tumours is grade 1 or 2 serous papillary adenocarcinomas. The prognosis in most patients is poor, thus, palliative treatment is usually indicated. We report a patient with ovarian carcinoma and widespread zosteriform skin metastases.
Guiti Sadeghian; Hengameh Ziai
Volume 10, Suppl.2 , 2007, , Pages 2-2
Abstract
A 30-year-old woman was referred to us with red and firm nodules on upper lateral aspect of left arm. These nodules were present for 15 years without pain but with intense pruritus.She reported uterine leiomyoma in the past, but family history for similar lesions was negative. Blood tests were normal, ...
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A 30-year-old woman was referred to us with red and firm nodules on upper lateral aspect of left arm. These nodules were present for 15 years without pain but with intense pruritus.She reported uterine leiomyoma in the past, but family history for similar lesions was negative. Blood tests were normal, but pelvis ultrasound showed a large uterine leiomyoma.Histologic examination of cutaneous lesions showed proliferation of smooth muscle cells with fascicular pattern in dermis. Pruritus was controlled with oral anti-histamine (loratadine). Plastic surgeons refused to remove the skin lesions due to their location and widespread distribution.
Smitha S Prabhu; Sathish Ballambat Pai; Manasa Narayan Kayarkatte
Abstract
Phototherapy is an essential and useful therapeutic procedure wherein the properties of ultraviolet light are used to cure certain dermatological conditions like psoriasis, vitiligo, and atopic dermatitis. This is usually an office-based procedure dependent on the accurate use of sophisticated phototherapy ...
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Phototherapy is an essential and useful therapeutic procedure wherein the properties of ultraviolet light are used to cure certain dermatological conditions like psoriasis, vitiligo, and atopic dermatitis. This is usually an office-based procedure dependent on the accurate use of sophisticated phototherapy units. Since the advent of the COVID-19 pandemic, phototherapy practices were shut down as they were considered as non-essential services. Here, we attempt to analyze how COVID-19 has affected phototherapy and seek to formulate a working guideline for safe phototherapy operations in these taxing circumstances. We used search engines like PubMed, Google Scholar, and Embase to retrieve articles and guidelines regarding phototherapy in dermatology, using the pertinent search terms. There was a paucity of data with only a couple of research letters and guidelines by the British Association of Dermatology and the American Academy of Dermatology, as well as general guidelines issued by the Indian Association of Dermatologists, Venereologists and Leprologists. After a careful study of various modalities of phototherapy and viral inactivation, we collated a set of guiding instructions toward the appropriate utilization of phototherapy amidst the COVID-19 pandemic. Phototherapy is a viable option for selected patients even amidst the COVID-19 pandemic. However, local and national guidelines have to be followed while selecting the patient and operating the phototherapy machine with adequate protective measures for both the patient and the healthcare worker. Home phototherapy units and PUVASOL are good options for those patients who are unable to attend the phototherapy center due to various reasons.
HC Williams
Volume 8, Issue 1 , 2004, , Pages 4-19
Abstract
Background: The publication of articles in peer-reviewed scientific journals is a fairly complex and stepwise process that involves responding to referees’ comments. Little guidance is available in the biomedical literature on how to deal with such comments. Objective: The objective of this article ...
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Background: The publication of articles in peer-reviewed scientific journals is a fairly complex and stepwise process that involves responding to referees’ comments. Little guidance is available in the biomedical literature on how to deal with such comments. Objective: The objective of this article is to provide guidance to notice writers on dealing with peer review comments in a way that maximizes the chance of subsequent acceptance. Methods: This will be a literature review and review of the author’s experience as a writer and referee. Results: Where possible, the author should consider revising and resubmitting rather than sending an article elsewhere. A structured layout for responding to referees’ comments is suggested that includes the 3 golden rules: 1) Respond completely; 2) Respond politely; and 3) Respond with evidence. Conclusion: Responding to referees’ comments requires the writer to overcome any feeling of personal attack, and to instead concentrate on addressing referees’ concerns in a courteous, objective, and evidence based way.
Moravvej Hamideh; Rad Mahnaz Mahmoodi; Zali Hakimeh; Nabai Leila; Toossi Parviz
Volume 12, Issue 1 , 2009, , Pages 4-8
Abstract
Background: Human fibroblasts are the part of the dermis that secrete extracellular matrix for the purpose of tissue repair. Culturing fibroblasts, which leads to formation of a monolayer of these cells, is used for treating various conditions including thermal burns and other skin defects such as diabetic ...
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Background: Human fibroblasts are the part of the dermis that secrete extracellular matrix for the purpose of tissue repair. Culturing fibroblasts, which leads to formation of a monolayer of these cells, is used for treating various conditions including thermal burns and other skin defects such as diabetic and varicose vein leg ulcers. Therefore, we aimed at developing a fibroblast bank to accomplish multiple goals including skin repair in defects such as burns and ulcers and also performing various research projects on these cells in order to further study of the mechanisms involved in wound healing, rejuvenation and medication effects. Method: We initially developed primary cultures of skin fibroblasts in a DMEM medium. These primary cultures were formed by washing and trypsinizing foreskin specimens followed by separation of epidermis from dermis and cutting the dermis into small pieces. In about 10 days, a monolayer of fibroblasts was formed. Result: We were able to develop the fibroblast bank successfully and to initiate other projects utilizing this bank. Conclusions: With these cultured cells, we would be able to perform different research projects including studying the mechanisms of wound healing, rejuvenation, drug affects, inflammatory mediators, growth factors, etc. Moreover, further progress in this field will result in our independence from requesting these cells from external sources.
Zahra Asadi-Kani; Soheila Nasiri; Parvaneh Vessal; Zohreh Tehranchinia; Majidreza Haghzare; Marjan Saeedi
Volume 15, Issue 1 , 2012, , Pages 4-6
Abstract
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in ...
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Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 with benign melanocytic lesions were enrolled in this study. Estrogen receptor beta expression in benign melanocytic lesions and melanoma was analyzed by using immunohistochemical staining. Result: All melanocytic lesions expressed estrogen receptor beta protein. We found lower estrogen receptor beta protein levels in melanoma. Conclusion: These initial observations, to be confirmed by further comprehensive studies, could suggest a role for estrogen receptor beta in melanoma, pointing at the possibility of using estrogen receptor beta expression for differentiating between malignant and benign lesions.
MJ Nazemi; SN Emadi; S Toosi
Volume 8, suppl , 2004, , Pages 5-10
Abstract
Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients ...
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Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients receiving cyclosporin. We report herein a 57-year-old woman who developed multiple warts on her hands and feet, lower lid syringomas, sebaceous gland hyperplasia of forehead and multiple mucosal irritation fibromas on tongue after kidney transplantation and a long course of treatment with oral cyclosporin, azathioprine and prednisolone since 6 years ago.
P Layegh; M Ebrahimi Rad; K Ghafar Zadegan
Volume 8, suppl , 2005, , Pages 5-9
Abstract
Porokeratosis of Mibelli is a keratinization disorder due to cellular clones that show different degress of dysplasia. Sometimes, these lesions develop on the previously traumatized or burnt skin. Herein, a 24 – year- old female patient is presented with three facial skin lesions on her right cheek ...
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Porokeratosis of Mibelli is a keratinization disorder due to cellular clones that show different degress of dysplasia. Sometimes, these lesions develop on the previously traumatized or burnt skin. Herein, a 24 – year- old female patient is presented with three facial skin lesions on her right cheek on a previous old scar due to cutaneous leishmaniasis is presented. The larger lesion was an erythematosquamous plaque with a well – defined hyperkeratotic margin and an atrophic center and two smaller erythematosquamous papules were located about 1.5 centimeter away from the main lesion. In the histopathologic evaluation of the skin biopsy of the patient, hyerkeratosis, irregular acanthosis and the characteristic column of parakeratotic cells (cornoid lamella) were evident. Considering clinical appearance of the lesion as well as the histopathologic findings, the patients was diagnosed as case of porokeratosis of Mibelli that was developed on an old scar due to cutaneous leishmaniasis.
Kassahun Desalegn Bilcha; Wondemagegn Enbiale; Tewfik Kassa
Volume 12, Suppl.3 , 2009, , Pages 5-7
Abstract
Fibroepithelial polyps, also named as soft warts, skin tags, or acrochordons, are common benign lesions that may occur on trunk or exterimities. Its association with infectious agents is unclear. Herein, We report a case of extensive fibroepithelial -like polyps on the foot of an AIDS patient following ...
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Fibroepithelial polyps, also named as soft warts, skin tags, or acrochordons, are common benign lesions that may occur on trunk or exterimities. Its association with infectious agents is unclear. Herein, We report a case of extensive fibroepithelial -like polyps on the foot of an AIDS patient following radiotherapy for Kaposi's sarcoma.
Kadian Randhir; El-Gamal Abdel Hamid; Al-Mehnna Basemahma; Al-Otaibi Sultan; Najem Nabeel
Volume 13, Issue 1 , 2010, , Pages 6-8
Abstract
Background: Tinea capitis is predominantly a disease of preadolescent children. Although worldwide in distribution, an increase in its prevalence in Kuwait has recently been reported, particularly in children. Tinea capitis frequently spreads among family members and classmates. The aim of this study ...
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Background: Tinea capitis is predominantly a disease of preadolescent children. Although worldwide in distribution, an increase in its prevalence in Kuwait has recently been reported, particularly in children. Tinea capitis frequently spreads among family members and classmates. The aim of this study was to determine the prevalence of tinea capitis among elementary school children of Al-Ahmadi province in Southern Kuwait. Method: This study was conducted between September 2006 and June 2007. All suspected cases of tinea capitis from 15 visited elementary schools were referred to the dermatology department at Al-Adan Hospital where a full history and examination was performed and the affected areas were scrapped. All obtained specimens were divided into two halves. The 1st half was mounted in a 20% potassium hydroxide solution and examined under light microscope. The 2nd half was cultured in Sabouraud's Dextrose Agar (SDA) 4% and incubated at 25-27°C for 4 weeks. Results: A total of 903 children from 15 elementary schools were included in this study out of which 191 children proved to have tinea capitis. Microsporum canis had the highest percentage (61.7%), while Trichophyton rubrum had the lowest (3.1%). Conclusion: Tinea capitis is a common fungal infection of the scalp in children. The grey patch type is the most common clinical type. A multi center study is needed to confirm the predominance of the isolated dermatophyte and to determine the modifiable and preventable risk factors.
Maryam Akhyani; Hasan Seirafi; Zahra Hallaji; Pardis Kiani; Sara Sabouri rad; Hosein Ahrar Mohammad
Volume 14, Issue 1 , 2011, , Pages 6-11
Abstract
Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of ...
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Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of AA with respect to age of onset, nail involvement, family history, number of recurrences and duration of the disease. Methods: A total of 239 consecutive patients with AA who were visited in our dermatology clinic from June 2009 to November 2009 were included in this study. The extent of scalp involvement, age of onset, nail involvement, family history, number of recurrences and duration of AA were recorded. Results: Two hundred and thirty nine (239) patients with AA including 141 males and 98 females entered our analysis (male: female ratio = 1.43:1). The age of the patients at the onset of the disease had a wide range from 1 to 60 years (mean ± SD = 21.51 ± 5.4). Two hundred and twelve patients (88.7%) had their first episode of AA before the age of 40 years. Duration of the AA varied from 1 month to 31 years. Ninety six (40.2%) patients experienced only one episode and 25 patients (10.5%) had more than 4 episode of alopecia. Nail changes was reported in 34 patients (14.2%). Forty five patients (18.8%) had a positive family history of alopecia areata. A personal history of atopy and autoimmune diseases was seen in 23 (9.6%) and 27 (11.3%) patients, respectively. The relationship between extensive AA and age of onset, duration, nail changes and positive family history was confirmed (p 0.05). Conclusion: AA occurred at a comparatively younger age. There was a correlation between extensive alopecia areata and age of onset, duration, nail changes, and positive family history as prognostic factors. There were no relationships between the severity of AA and sex, history of atopy and autoimmune diseases.
Farhad Handjani; Nasrin Saki; Bahareh Kardeh; Masoomeh Maghsoodi
Volume 16, Issue 1 , 2013, , Pages 6-8
Abstract
Background: Hirsutism is defined as the presence of terminalhairs with a male-like pattern in women, due to the increasedlevels of androgens or increased responses of the target organs toandrogens. Facial hirsutism has a negative effect on the quality oflife in female patients. Among the many therapeutic ...
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Background: Hirsutism is defined as the presence of terminalhairs with a male-like pattern in women, due to the increasedlevels of androgens or increased responses of the target organs toandrogens. Facial hirsutism has a negative effect on the quality oflife in female patients. Among the many therapeutic modalitiesfor hirsutism, laser therapy is of great acceptability. The longpulse Alexandrite laser, diode laser, and Nd:YAG laser are themost commonly used lasers in the treatment of hirsutism. In thisstudy, we assessed the effect of laser therapy on the quality oflife of the patients with hirsutism, using the Dermatology LifeQuality Index (DLQI) and Visual Analog Scale (VAS).Method: Forty-two female patients with idiopathic hirsutism,ranging from 18 to 34 years old, were studied during a courseof laser therapy lasting for at least 4 months for up to 3 courses.Each patient completed a DLQI and VAS questionnaire beforeand after treatment. The VAS questionnaire was also filled outby the dermatologist.Result: Following laser therapy, the average DLQI score,decreased by 10 points (a statistically significant difference withp- value<0.001). VAS also declined and there was a moderate togood correlation between the VAS scores given by the patientand the dermatologist.Conclusion: This study demonstrated that laser therapy improvedthe quality of life in patients with hirsutism.
Ghiasi Maryam; Hallaji Zahra; Narimani Shaban Ali
Volume 18, Issue 1 , 2015, , Pages 6-9
Abstract
Background: Psoriasis is a chronic immune-mediated skin diseasewith a genetic predisposition. Prolactin may contribute to psoriasispathogenesis. However, there has been a debate over the serumlevel of prolactin in psoriatic patients. The aim of this study was todescribe the role of serum prolactin in ...
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Background: Psoriasis is a chronic immune-mediated skin diseasewith a genetic predisposition. Prolactin may contribute to psoriasispathogenesis. However, there has been a debate over the serumlevel of prolactin in psoriatic patients. The aim of this study was todescribe the role of serum prolactin in the pathogenesis of psoriasisMethod: The serum prolactin level was measured in 45 patientswith psoriasis and in 45 sex- and age-matched healthy individualsusing radioimmunoassay.Result: The mean serum prolactin concentration was not differentbetween psoriatic patients and healthy controls (320 ± 179.38 vs.318.18 ± 191.78 mIU/L, respectively P = 0.95). There was no sexandage-related differences in serum prolactin between the twostudy groups. Hyperprolactinemia (serum prolactin >324 mIU/Lin men, and >496 mIU/L for women) was observed in 11 patientswith psoriasis and 12 healthy subjects, which showed no significantdifference between the two groups (P = 0.81). The serum prolactinwas not significantly correlated with the duration of the disease(r = -0.18, P = 0.24) or the PASI score (r = 0.10, P = 0.50).Conclusion: The possible role of pituitary-produced circulatingprolactin in the disease process needs further investigations.
Ghiasi Maryam; Daneshpazhooh Maryam; Balighi Kamran; Ghiasi Fatemeh
Volume 20, Issue 1 , 2017, , Pages 6-10
Abstract
Background: Intravenous immunoglobulin (IVIG) is used to treat many autoimmune and immunodeficiency disorders. The main indications of IVIG in dermatology include treatment for resistant autoimmune bullous diseases, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Although generally ...
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Background: Intravenous immunoglobulin (IVIG) is used to treat many autoimmune and immunodeficiency disorders. The main indications of IVIG in dermatology include treatment for resistant autoimmune bullous diseases, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Although generally welltolerated, various adverse effects can occur.Methods: We designed a retrospective study to investigate the adverse effects of IVIG in all patients who received this drug in Razi Hospital from 2005-2016. Information was gathered from patients’ medical records.Results: During the study period, 67 patients received 94 IVIG infusions. The most common underlying dermatologic disease was pemphigus vulgaris (54 patients). The most frequent adverse effect of IVIG therapy was an increase in blood pressure for 17 patients and in 21 infusions of IVIG. Other adverse reactions included fatigue and generalized weakness, fever, chills, tachycardia, dizziness, a decrease in blood pressure, headache, flushing, chest discomfort, hemolysis, leukopenia, and deep vein thrombosis.Conclusions: Adverse events associated with IVIG therapy are usually mild and self-limiting. The incidence of serious adverse events is low. Identification of risk factors and close monitoring of high risk patients are essential to decrease the occurrence of serious adverse events.
Mohammad Ebrahimzadeh; Ali Pedarzadeh; Farideh Dehghani; Mohammad Moslemzadeh
Volume 19, Issue 1 , 2016, , Pages 6-10
Abstract
Background: Worldwide, coronary heart disease is the most important cause of mortality and morbidity. Although numerous studies have documented the relationship between male pattern baldness and cardiovascular disease (CVD), few studies focused on this association in women. This study intended to evaluate ...
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Background: Worldwide, coronary heart disease is the most important cause of mortality and morbidity. Although numerous studies have documented the relationship between male pattern baldness and cardiovascular disease (CVD), few studies focused on this association in women. This study intended to evaluate the relationship between coronary artery disease and androgenetic alopecia (AGA) in both men and women.Methods: This case-control study included 200 people, 100 (50 men and 50 women) with coronary heart disease (CHD) and 100 healthy control subjects (50 men and 50 women). Both groups were assessed for grading the severity of their baldness. The collected data were analyzed by the chi-square test.Results: A total of 74% of participants in this group had hair loss severity of grades IV-VIII, however in the control group, 50% had remarkable hair loss. There was a significant association between coronary artery disease and hair loss grade IV onward in men (P=0.038) but this relationship was not observed in women.Conclusion: Male patients with AGA are at greater risk for developing CVD.
Akhyani Maryam; Jafari Alireza Keshtkar; Seyrafi Hassan; Ghaninedjad Hayedeh; RezaPazouki Hamid; Tousi Siavash; Robati Reza Mahmood; Davari Parastoo; Firooz Alireza
Volume 11, Issue 1 , 2008, , Pages 7-10
Abstract
Background: Latanoprost, a prostaglandin F 2a analogue, is an intraocular pressure lowering drug used in the treatment of glaucoma. Increase in eyelash number, length, pigmentation, curvature is reported after using topical Latanoprost in these patients. The aim of this study was to evaluate the effect ...
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Background: Latanoprost, a prostaglandin F 2a analogue, is an intraocular pressure lowering drug used in the treatment of glaucoma. Increase in eyelash number, length, pigmentation, curvature is reported after using topical Latanoprost in these patients. The aim of this study was to evaluate the effect of Latanoprost ophthalmic solution on eyelash regrowth in patients with alopecia areata.Methods: Fifteen patients with alopecia areata and bilateral eyelash involvement, who showed excellent response to diphencyprone therapy, entered the study to be treated with Latanoprost ophthalmic solution. In each patient, one eye was randomly treated with Latanoprost daily over 3 months. To assess the eyelash changes, patients were followed up monthly. Results: Ten patients completed the study. Two patients had significant eyelash regrowth of both eyes. One patient showed eyelash regrowth on upper eyelid of the eye treated with Latanoprost. Conclusion: In this study, Latanoprost was not effective in treatment of alopecia areata of eyelashes. It is advisable to evaluate the efficacy of higher concentration and/or more frequent application of the Latanoprost with an appropriate vehicle for the treatment of alopecia areata of eyelashes.
Hajheydari Zohreh; Saeedi Majid; Hosseinzadeh Mohammad
Abstract
Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, ...
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Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, zinc, and copper levels with seborrheic dermatitis. Methods: A prospective case-control study was performed on 30 patients with seborrheic dermatitis and 30 age and sex-matched healthy volunteers as a control group. Trace elements were measured by atomic absorption spectrophotometer in both groups. Results: The mean serum selenium, zinc, and copper levels were 98.90 ± 27.61 ?g/dL, 91.27 ± 10.84 ?g/dL, and 100.9 ± 20.06 ?g/ dL in case groups, respectively. In the control group, the mean serum selenium, zinc, and copper levels were 91.61 ± 15.74 ?g/dL, 94.03 ± 11.11 ?g/dL, and 96.5 ± 15.82 ?g/dL, respectively. There was no significant difference between the mean serum selenium, zinc, and copper levels in case and control groups (P>0.05). Conclusions: Although no statistically significant relationship was observed in serum selenium, zinc, and copper levels between the cases and controls, the serum selenium level among patients in case group was higher than that in the healthy subjects.
SM Meghdadi; M Moslemi; F Iraji
Volume 3, Issue 3 , 2000, , Pages 7-13
Abstract
Background: Considering the prevalence of skin lesions and drug eruptions in intensive care units and the absence of research about it, we decided to study skin lesions of patients admitted in intensive care unit. Patients and Methods: In this descriptive study all patients admitted in intensive care ...
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Background: Considering the prevalence of skin lesions and drug eruptions in intensive care units and the absence of research about it, we decided to study skin lesions of patients admitted in intensive care unit. Patients and Methods: In this descriptive study all patients admitted in intensive care units of Al-Zahra Hospital in Isfahan in 1376-78 were observed and examined by a resident in Dermatology. Skin biopsy and bacterial and fungal smears were done in selected cases. Data were collected, entered in SPSS and analyzed by ANOVA, Chi-square and Discriminant methods. Results: 197 of a total of 406 patients had skin lesions. Skin lesions were most frequent in the age range of 21-40 years (37%) and least frequent in age groups under 10 years (2.5%) and over 80 years (3%). 116 of patients (58.9%) were male and 81 (41.1%) were female. The most common skin lesions were hemorrhagic cutaneous lesions (23.4%) and steroid acne (22.8%). The rarest was toxic epidermal necrolysis (0.5%). The most common causes of hospitalization were intracranial and subarachnoid hemorrhage (11.2% each). Conclusion: Skin lesions are common in patients admitted in ICUs. Frequent and continuous examinations of these patients are recommended in order to prevent and treat them promptly.
AR Fekri; S Shamsaddini; A Maghsoodloo Nejad
Volume 3, Issue 4 , 2000, , Pages 7-17
Abstract
Background: Beta-thalassemia major (BTM) is a genetic disorder, which is common in Kerman province of Iran. New methods of care has increased their survival. Objective: The objective of this descriptive study was to assess the frequency of skin and mucosal complications of BTM patients. Patients and ...
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Background: Beta-thalassemia major (BTM) is a genetic disorder, which is common in Kerman province of Iran. New methods of care has increased their survival. Objective: The objective of this descriptive study was to assess the frequency of skin and mucosal complications of BTM patients. Patients and Methods: All BTM patients referred to Kerman-Darman Hospital in 1377 (150 cases) were evaluated. Dermatologic signs and symptoms were diagnosed by physical examination and serum ferritin levels were measured. Results: Skin hyperpigmentation (65.3%), mucosal hyperpigmentation (41.3%), coarse nail (34%) and coarse hair (20.7%) were the most common signs. They were related to the age and serum ferritin levels but sex of patients and dose of desferral had no significant relation with skin complications. Conclusion: Skin and mucosal lesions are common in BTM. An exact exam and control of serum ferritin level with desferral is recommended to prevent skin complications.
R Yaghoobi; R Rafiei; F Savad Dar; SM Latifi
Volume 5, Issue 3 , 2002, , Pages 7-14
Abstract
Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. However, the incidence, histologic subtypes, and tumor behaviors are quite different in Asians and western populations. Objective: This study was designed to survey the clinicopathological aspects of ...
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Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. However, the incidence, histologic subtypes, and tumor behaviors are quite different in Asians and western populations. Objective: This study was designed to survey the clinicopathological aspects of malignant melanoma among Khouzestan people. Patients and Methods: In a retrospective study 62 patients (28 women, mean age 53.80±14.1, and 34 men, mean age 55.9±15.8) were diagnosed as melanoma in Khouzestan province, southwest of Iran during 1990-2000. The analyzed data included sex, age at diagnosis, location and histologic subtypes. Results: Malignant melanoma was found to be more common in men than women, in the approximate ratio of 5 to 4. From 62 cases of malignant melanoma, 59.67% were cutaneous, 19.35% metastatic in lymph nodes, 11.29% ocular, 4.83% gastrointestinal tract, 3.22% mucosal, and 1.61% inner ear and mastoid. The majority of cases were unclassified malignant melanoma (30.64%), followed by nodular melanoma (27.41%), metastatic malignant melanoma (24.19%), acral lentiginous melanoma (12.9%), and lentigo maligna melanoma (4.84%), respectively. Conclusion: Although malignant melanoma is a rare tumor in Khouzestan, further studied are necessary to analyze present and future trends of melanoma, accurately. Ongoing and new prevention and control strategies may be mandatory to curtail the melanoma outbreak.
Herwinda Brahmanti; Aunur Rofiq; Moch Cholis; Unundya Trijayanti; Sasi Purwanti
Abstract
Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 ...
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Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited in Indonesia, particularly in Malang city. The objective of the present study was to understand the association of LL-37 and IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD) in atopic dermatitis patients.Methods: The present research is an analytical observational cross-sectional study with 30 atopic dermatitis patients as subjects. Through a consecutive sampling method, samples were collected from the outpatient clinics of dermatovenereology and pediatric department, Dr. Saiful Anwar General Hospital (RSSA), Malang, Indonesia. LL-37 and IL-31 serum levels were examined via Enzyme-Linked Immunosorbent Assay (ELISA) method. Subjects were allocated into two groups of atopic dermatitis severity, mild and moderate-severe, based on the SCORAD index.Results: Based on the Pearson correlation test, there was no correlation between LL-37 serum level, IL-31 serum level and the SCORAD score (r=-0.238 with P=0.205, and r=0.15 with P=0.939).Conclusion: LL-37 and IL-31 serum levels are not associated with atopic dermatitis severity.
Layegh Pouran; Meibodi Naser Tayyebi; Nahidi Yalda; Sepehri Zahra; Nazari Ali; Shakeri Mohammad Taghi
Volume 17, Issue 1 , 2014, , Pages 8-12
Abstract
Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible ...
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Background: The description on patients with pigmented back patches is rarely reported in the literature. We decided to study the clinicopathological aspects of these patients for reaching a better understanding of this disease.Method: In this study, the clinicopathological aspects and probable responsible factors in the manifestation of posterior pruritic pigmented patches in patients referred to the dermatology clinic of Qaem University Hospital from October 2007 to September 2009 were surveyed.Result: All 60 patients who were enrolled in our study were female with a mean age of 31.43±9.71 years. Six patients did not consent to biopsy. The most c
N Darvish Zadeh
Volume 4, Issue 4 , 2001, , Pages 8-14
Abstract
Background: Dermatomyositis is an autoimmune inflammatory myopathy with distinct cutaneous findings. Its etiology is unknown. Objective: The purpose of this study was to evaluate demographic, clinical and paraclinical findings in patients with dermatomyositis in Ahwaz. Patients and Methods: This is descriptive, ...
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Background: Dermatomyositis is an autoimmune inflammatory myopathy with distinct cutaneous findings. Its etiology is unknown. Objective: The purpose of this study was to evaluate demographic, clinical and paraclinical findings in patients with dermatomyositis in Ahwaz. Patients and Methods: This is descriptive, retrospective study and the records of all patients with dermatomyositis admitted to Sina hospital in Ahwaz from December 1990 to March 2000 analyzed. Results: 10 cases with dermatomyositis were admitted during the time. The ages of 5 patients were less than 16 years and 5 were over twenty years. Nine of the patients were female and 1 was male. Heliotrope rash was the first cutaneous sign in 9 and 6 patients had Gottron’s papules. All of the patients had proximal muscle myopathy and 1 patient also had nasopharyngeal involvement. The most common abnormal laboratory tests were the rise of SGOT and CPK. EMG were done on 9 patients and all had diagnostic findings. 1 patient was pregnant and she also had pneumonia and perianal abscess. In 1 patient wound healing was impaired. None of patients had malignancy. Conclusion: Dermatomyositis is more common in women then in men and the most common sign of the disease is heliotrope rash in Ahwaz.
F Iraji; M Rezazadeh
Volume 6, Issue 3 , 2003, , Pages 8-12
Abstract
Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison ...
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Background: Topical corticosteroids are currently used for treatment of diaper dermatitis. Previous studies have shown the efficacy of sucralfate in the treatment of diaper dermatitis and contact dermatitis in peri-stomy areas. Objectives: To evaluate the efficacy of topical sucralfate in comparison with hydrocortisone cream in the treatment of diaper dermatitis. Patients and Methods: In a double-blind, randomized clinical trial, 64 patients with diaper dermatitis were treated with sucralfate cream 4% or hydrocortisone cream. The duration of treatment was 8 weeks and patients were evaluated every two weeks until complete healing. The results were evaluated with chi-square test. Results: Complete healing (More than 50% improvement) occurred in 90.6% and partial healing (20-50% improvement) in 9.4% of patients in each group (P>0.05). Conclusion: Topical sucralfate is an effective, available and cheap therapeutic intervention for diaper dermatitis, which has equal efficacy with topical hydrocortisone cream.
S Emmet
Volume 1, Issue 2 , 1998, , Pages 9-12