R Salmanpour; MJ Rahmanian
Volume 4, Issue 2 , 2001, , Pages 9-12
Abstract
Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect ...
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Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect of botulinum toxin A (Dysport) in the treatment of axillary hyperhidrosis. Patients and Methods: After visualization of hyperhidrosis using the iodine-starch test, ten patients with axillary hyperhidrosis underwent intradermal injection with 125 units of Dysport in the axillary skin bilaterally. Patients were observed for 7 months after treatment. Results: The treatment was well tolerated without side effects. All patients experienced relatively complete anhidrosis of the axillary skin after about one week for periods lasting from 4 to 7 months. Conclusion: Botulinum-A toxin may offer a fast, safe, and highly effective therapeutic option for severe hyperhidrosis.
ZB Mousavi; A Ebrahimi; M Mirian
Volume 5, Issue 1 , 2001, , Pages 9-19
Abstract
Background: During imposed war (1980-1988) Iraq frequently used chemical warfare particularly mustard gas. Skin is frequently involved in victims. Objective: Our main objective was to evaluate chronic skin manifestations due to exposure to mustard gas 10-19 years after exposure in a case-control study. ...
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Background: During imposed war (1980-1988) Iraq frequently used chemical warfare particularly mustard gas. Skin is frequently involved in victims. Objective: Our main objective was to evaluate chronic skin manifestations due to exposure to mustard gas 10-19 years after exposure in a case-control study. Patients and Methods: 101 chemically wounded combators and 121 non-chemically wounded combators were randomly selected and examined by dermatologists. Laboratory tests were done for 30 subjects in each group. Data were analyzed by SPSS/PCT # 5 software using student-t and chi-square tests with Yates correction. Results: Seven itching, burning sensation, skin tightness and dryness, hypo and hyper pigmentation, telangiectasia, melanocytic nevus, cherry angioma, lichenification, alopecia areata, recurrent aphthous stomatitis, tinea versicolor, acute eczema on lower extremities were significantly more common in chemically wounded than the control group. Lymphopenia, lower serum IgM, and higher serum IgG wee also more common in the exposed group. Conclusion: Several skin disorders are more common in chemical gas victims, even several years after exposure. This finding shows that more research on various subjects such as alterations in immune system, adequate training on protective measures, pathophysiology of pruritus and molecular changes are necessary to find better treatment and effective vaccine.
Giti Sadeghian; Masoomeh Sadeghi
Volume 10, Issue 1 , 2007, , Pages 9-12
Abstract
Background and aim: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs have some side effects such as cardiotoxicity. The objective of this study was to evaluate the electrocardiographic (ECG) changes in patients with ...
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Background and aim: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs have some side effects such as cardiotoxicity. The objective of this study was to evaluate the electrocardiographic (ECG) changes in patients with CL treated with systemic Glucantime.Materials and methods: This study with simple sampling method was done on patients with CL who had indication for treatment with systemic Glucantime. Before and during the treatment (weekly) and 1 month after stopping the treatment ECGs were taken from patients. The patients with baseline abnormal ECG were not included in the study.Results: 131 patients were enrolled in this study. The most common change was prolonged QT interval that was seen in 19% of patients. ST depression occurred in 6.1% and minimal ST elevation occurred in 3%, inverted T was observed in 7.4% of patients. Single PAC and single PVC occurred in 0.7% and 2.29%, respectively. Also we observed bradycardia in 10.6% and left bundle branch block in 0.7% of the patients. All of these changes reversed 1 month after treatment except for left bundle branch block.Conclusion: Important ECG changes are minimal in CL patients with normal baseline ECG treated with Glucantime and its administration seems to be safe.
Z Rahnama; AA Haghdoost
Volume 6, Issue 1 , 2002, , Pages 10-15
Abstract
Background: Squamous cell carcinoma has a wide range of histological differentiation, which indicates the prognosis. Location of the tumor also affects its prognosis. Objective: To determine the relationship between location of the tumor, age and sex of patients and histological grading of it. Patients ...
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Background: Squamous cell carcinoma has a wide range of histological differentiation, which indicates the prognosis. Location of the tumor also affects its prognosis. Objective: To determine the relationship between location of the tumor, age and sex of patients and histological grading of it. Patients and Methods: In this retrospective study, 44631 files of the patients who were referred to two main pathological centers in Kerman from 1992 to 1999 were reviewed, and the data of 186 cases of skin squamous cell carcinoma were extracted and analyzed. Results: In 186 cases of skin squamous cell carcinoma, the mean age of patients was 60.4±16.6 years. 133 patients (70.9%) were male and 53 cases (29.1%) were female, so male to female ratio was 2.5 to 1. The most common sites of involvement were head and neck (76.8%), upper extremities (10.2%), trunk and genitalia (6.8%) and lower extremities (6.2%). 81.5% of tumors were well differentiated, 14.3% were moderately and 4.2% were poorly differentiated. There was no relationship between age, sex and site of the lesion with grading of the tumor. Conclusion: In order to manage squamous cell carcinoma properly, performing biopsy in all cases is mandatory.
MA Nilforoosh Zadeh; MM Fakhri Shooshtari; F Djafari
Volume 5, Issue 4 , 2002, , Pages 10-15
Abstract
Background: A wide variety of cutaneous and mucosal lesions occur in renal transplant recipients. Objectives: Evaluation of the skin and mucous membrane lesions in the kidney transplant recipients in Noor and Ali Asghar Hospital in Isfahan. Patients and Methods: This cross-sectional descriptive study ...
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Background: A wide variety of cutaneous and mucosal lesions occur in renal transplant recipients. Objectives: Evaluation of the skin and mucous membrane lesions in the kidney transplant recipients in Noor and Ali Asghar Hospital in Isfahan. Patients and Methods: This cross-sectional descriptive study was done on 117 patients (82 male, 35 female), who had received kidney transplants and referred to Noor and Ali Asghar Hospital during July and August 1997. Results: Hypertrichosis was the most common finding observed in 73%. Other lesions were acne (33%), folliculitis (26%), gingival hyperplasia (19%), common warts (18%), and recurrent herpes simplex infection (3%). Basal cell carcinoma was present in 3 patients and one patient had Kaposi’s sarcoma. Conclusion: Except for skin tumors, the results of this study revealed similar prevalence of skin lesions in renal transplantation patient with those reported in the literature, which emphasizes on the importance of periodic skin examinations in these patients.
Sh Enshaieh; A Kiani
Volume 3, Issue 1 , 1999, , Pages 11-15
Abstract
Background: Cutaneous Leishmaniasis is one of the most common parasitic diseases in Isfahan, the scar of it could be found in the majority of residents of some areas of city. This disease can affect all age groups but it is more common in children in endemic and hyperendemic areas. Objective: The purpose ...
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Background: Cutaneous Leishmaniasis is one of the most common parasitic diseases in Isfahan, the scar of it could be found in the majority of residents of some areas of city. This disease can affect all age groups but it is more common in children in endemic and hyperendemic areas. Objective: The purpose of this study was to evaluate clinical features of cutaneous leishmaniasis in children less than 12 years old in Isfahan. Patients and Methods: We studied 656 cases younger than 12 years among 2000 patients referred to “Center of Leishmaniasis” in Isfahan, from October 96 to October 97. The diagnosis of cutaneous leishmaniasis was confirmed by direct smear in all cases. Results: Among 2000 patients, 656 cases (32.8%) were less than 12 years old, 53.4% of them were male and 46.6% were female. Most of the lesions were papules (28.4%), and the most common site of involvement was face (38.6%). The number of lesions ranged from 1 to 20, but most of the patients had only one lesion (46.3%).
M Valikhani; M Barzegari; F Aghainia
Volume 5, Issue 2 , 2002, , Pages 11-14
Abstract
Background: Localized and extensive clinical subtypes of alopecia areata (AA) including alopecia totalis and alopecia universalis differ in genetic and immunologic aspects. Objective: Comparison of epidemiologic aspects of localized and extensive subtypes of AA. Patients and Methods: In a prospective ...
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Background: Localized and extensive clinical subtypes of alopecia areata (AA) including alopecia totalis and alopecia universalis differ in genetic and immunologic aspects. Objective: Comparison of epidemiologic aspects of localized and extensive subtypes of AA. Patients and Methods: In a prospective descriptive study, 180 patients suffering from AA attending the skin clinics of Razi Hospital in Tehran in 6-month period were studied. The epidemiological aspects of the disease including age at onset, duration, family history, and mental stress were compared in the localized and extensive subtypes of AA. Results: The age at onset was 13.2 years in localized and 19.3 years in extensive AA (P<0.05). The duration of disease was remarkably longer in the extensive form (42.5 months vs. 17.5 months in localized AA). The role of mental stress was mentioned in 55.6% of cases with extensive form and 27.8% of cases with localized AA (P<0.05). There was no relation between family history of AA and the clinical subtype of disease. Conclusion: Extensive AA begins at a younger age, has longer course, and stronger relation with stress.
AR Firooz; M Rashighi Firoozabadi; B Ghazi Saidi; Y Dowlati
Volume 4, Issue 3 , 2001, , Pages 11-17
Abstract
Background: Alopecia areata (AA) is a common disease with an unknown etiology. It is a chronic disease with causes severe disfigurement. So it may significantly affect the patients’ quality of life (QOL). This study was designed to evaluate illness perception and QOL in patients with AA. Patients ...
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Background: Alopecia areata (AA) is a common disease with an unknown etiology. It is a chronic disease with causes severe disfigurement. So it may significantly affect the patients’ quality of life (QOL). This study was designed to evaluate illness perception and QOL in patients with AA. Patients and Methods: A questionnaire consisting of 28 questions about causes, course and the impact on QOL were given to patients with AA older than 12 years attending a private skin clinic in 1999 in Tehran. The questions were asked as closed questions and the patients answered them anonymously as “I agree”, “I do not know” and “I disagree”. Only questionnaires with more than 80% of questions answered were analyzed. The role of age, sex, duration, previous treatment, education, severity and family history of AA were assessed. Results: 80 patients (42 male and 38 female) with a mean age of 27.5±9.3 years and disease duration of 7.8±7.7 years entered the study. 60 of them had AA and 20 had alopecia totalis/universalis (AT/AU). 77% of patients believed on the role of stress as the cause of disease, more in older patients and shorter duration. 17% believed on the role of genetic background, more in patients with positive family history of AA or longer duration of disease. AA had a pronounced effect on QOL of 58% of patients, more in younger patients. 51% of patients considered their disease as severe, more in younger patients or severe disease. Only 58% of patients considered their treatments effective and 49% of them believed it will improve with praying. Conclusion: AA may considerably affect various aspects of patients’ lives. The knowledge of patients about the causes and course of this disease is very limited. Physicians should spend more time on the education of patients.
F Handjani; M Nasseri
Volume 6, Issue 4 , 2003, , Pages 11-16
Abstract
Background: Tinea versicolor is a superficial fungal infection caused by normal skin flora and treatable by topical and oral anti-fungal medications. Objective: To evaluate the clinical and paraclinical response and to compare possible side-effects of a single oral dose of fluconazole and ketoconazole ...
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Background: Tinea versicolor is a superficial fungal infection caused by normal skin flora and treatable by topical and oral anti-fungal medications. Objective: To evaluate the clinical and paraclinical response and to compare possible side-effects of a single oral dose of fluconazole and ketoconazole in treatment of tinea versicolor. Patients and Methods: In this clinical trial, sixty-six definite cases of tinea versicolor were divided in two groups using a simple randomization method. The first group consisted of 33 patients who were treated with a single oral dose of 300mg of fluconazole. The second group also consisted of 33 patients who received ketoconazole 400mg orally as a single dose. The patients were evaluated 2 weeks after treatment for therapeutic and paraclinical responses as well as possible side effects. Results: Clinical and paraclinical responses were 60.6% and 78.7% in the first group (Fluconazole) and 33.3% and 51.5% in the second group (Ketoconazole), respectively (P<0.05): There was no statistical difference as far as side-effects were considered (P>0.05). Conclusion: The therapeutic effect of fluconazole as a single oral dose was more than ketoconazole in the treatment of tinea versicolor.
Z Safaei Naraghi; Z Hallaji; M Danesh Pajooh; H Moslehi; K Jazayeri
Volume 4, Issue 1 , 2000, , Pages 12-18
Abstract
Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the ...
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Background: Bullous pemphigoid (BP) is the prototype of subepidermal autoimmune bullous dermatoses (SABDs). Direct immunofluorescence on salt split skin substrate (DIF-SS) is one of the methods used to differentiate this group of dermatoses. Objective: We conducted this study in order to delineate the results of DIF-SS in SABD patients. Patients and Methods: Seventeen patients with a BP-like clinical picture referred to Razi Hospital in 1378, who had linear immunodeposits along basement membrane zone in direct immunofluorescence, were studied. Considering only histopathologic and clinical data, a final diagnosis was established for each patient. DIF-SS was performed on perilesional skin sample of patients. DIF-SS and histopathology results and the final diagnosis were recorded and compared for each patient. Results: In DIF-SS, eleven patients (65%) had combined (Epidermal and dermal), two patients (12%) had epidermal and four patients (23%) had dermal pattern. The final diagnoses were BP in ten patients and epidermolysis bullosa acquisita (EBA) in two others. We were unable to differentiate BP from EBA in two patients. In ten patients who were diagnosed finally as BP, nine patients (90%) had combined pattern and only one case (10%) showed epidermal staining in DIF-SS. Conclusion: Surprisingly, in contrast to the results of the previous studies on pemphigoid patients using either IIF-SS or DIF-SS in which the epidermal pattern had been reported to be much more common than the combined pattern, the combined pattern was nine times more frequent than the epidermal pattern in this study. Perhaps, the difference in target antigens in our patients may be the underlying reason for the difference in our results.
ZB Mousavi
Volume 2, Issue 4 , 1999, , Pages 12-16
Abstract
Background: Diffuse hair loss is one of the most common complaints of women attending skin clinics. Objective: The purpose of this study was to evaluate diffuse hair loss in women referring to a private office. Patients and Methods: This descriptive, retrospective study was performed on women attending ...
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Background: Diffuse hair loss is one of the most common complaints of women attending skin clinics. Objective: The purpose of this study was to evaluate diffuse hair loss in women referring to a private office. Patients and Methods: This descriptive, retrospective study was performed on women attending a private skin clinic in Ahwaz complaining of diffuse hair loss. The study was done for 10 months in 1376-77. The patients who were hirsute or had apparent clinical pattern of androgenetic or scarring alopecia were excluded. Results: 68% of the total of 180 patients aged between 10 to 30 years old. Thyroid function disorders was found in 18.8%, and anemia was the only finding in 23% of the patients. Trichotillomania was observed in 3.2% and in 41.4% we could not find any clinical or laboratory positive finding. Conclusion: Women complaining of diffuse hair loss should be screened for thyroid disorders and anemia.
A Athar Moein
Volume 2, Issue 1 , 1998, , Pages 13-16
Abstract
Atopic dermatitis is one of the commonest childhood diseases. Large variations in the prevalence of the disease have been observed in different studies. This variation in the prevalence may be not only from genetic and environmental factors but also from methodology of estimating prevalence of the disease. ...
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Atopic dermatitis is one of the commonest childhood diseases. Large variations in the prevalence of the disease have been observed in different studies. This variation in the prevalence may be not only from genetic and environmental factors but also from methodology of estimating prevalence of the disease. In this study, Hanifin and UKWP criteria have been used in determining prevalence of the atopic dermatitis in school children. Firstly, the educational areas and schools were chosen by the systematic random sample. Then, the disease prevalence of the first and fifth grade students was determined by considering the parental questionnaires and physical examination. The prevalence of AD was 0.8% with Hanifin and 1.5% with UKWP criteria. The overall prevalence of dermatitis was 7.9%. Therefore, the prevalence of AD in a population varies based on the method used. It is very important for a researcher to use the standard methodology where it is possible or define the disease carefully. There is still some needs in determining more sensitive, specific and practical criteria for the diagnosis of AD.
H Edalat Khah; M Mirza Namadi
Volume 6, Issue 2 , 2003, , Pages 14-19
Abstract
Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship ...
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Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship between melasma and polycystic ovarian disease and androgenic hormones. Patients and Methods: This case-control study was performed on 101 patients with melasma and 101 control patients referred to the skin clinic of Ardebil University of Medical Sciences. Serum levels of LH, FSH, DHEAS, prolactin, testosterone and 17-hydroxy progesterone were measured and sonography of ovaries was done. Results: The age of the study subjects ranged from 15 to 45 years. There was no significant difference in serum levels of any of hormones between cases and control groups (P<0.05). Ovarian cysts were found in 65.3% of melasma patients and 47.5% of control patients (P=0.01). Conclusion: These results confirm the possible role of ovarian cysts or another common etiologic factor in melasma. More studies are required in this subject.
M Akhyani; H Mortazavi; M Izadi; AH Ehsani
Volume 7, Issue 1 , 2003, , Pages 14-18
Abstract
Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin ...
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Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin in the treatment of patients with pityriasis rosea. Patients and Methods: In this double-blind randomized clinical trial, 46 patients with pityriasis rosea in two equal groups were treated with oral erythromycin 1gr per day or placebo for seven days and were followed 1, 2 and 6 weeks after treatment. The response to the treatment was evaluated as complete, partial and no response. Results: In 48% of the case group and 13% of the control group complete response was seen at the end of first week of treatment. Moreover, these rates reached 91% and 57% at the end of second week, 100% and 87% at the end of sixth week, respectively. The differences between two groups were statistically significant after first and second weeks. Conclusion: Oral erythromycin was effective in the treatment of patients with pityriasis rosea. Also, it reduces the duration of disease.
E Firooz Ebne Ahmadi; P Sooudi; Y Dowlati
Volume 2, Issue 3 , 1999, , Pages 15-20
Abstract
Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed ...
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Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed to identify the relationship of stress with psoriasis expression and the severity of skin lesions. Materials and Methods: This is a prospective case-control study with simple random sampling which has been performed on 95 subjects above 18 year old in Razi Hospital. The case group was selected from psoriatic patients and the control group from non-psoriatic patients in whom stress does not have any effect on their disease. Two groups were matched for age and sex. Stress was assessed by Holmes and Rahe protocol with some modifications approved by a psychiatrist. Severity of skin lesions in psoriatic patients was also assessed by PASI score. Data Analysis was performed by T test, multiple logistic regression and correlation of Spearman using SPSS (6) software. Results: The mean of severity of stress in psoriatic group was higher than control group (P=0.021). On the other hand, there was a relationship between stress and psoriasis expression; but there was no statistically significant correlation between severity of stress and severity of skin lesions in psoriatic patients (P=0.268). Discussion: Paying attention to the effect of stress on the expression of psoriasis, it is suggested to use psychological methods in addition to routine treatment: So we can reduce emotional stress and shorten the course of this disease.
N Darvishi Zadeh
Volume 3, Issue 2 , 2000, , Pages 16-22
Abstract
Background: Non-melanocytic skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are mostly induced by long life sun ultraviolet radiation (UVR). Although many etiological factors are known in skin cancer, the role of sunlight is the most prominent. Khuzestan is ...
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Background: Non-melanocytic skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are mostly induced by long life sun ultraviolet radiation (UVR). Although many etiological factors are known in skin cancer, the role of sunlight is the most prominent. Khuzestan is one of the southern provinces of Iran, which has sunny sky and long summer. So it is presumed that skin cancers are common in Khuzestan. Objective: To study non-melanocytic skin cancers in Ahwaz. Patients and Methods: In this retrospective study, pathological diagnosis of NMSC in an educational hospital of the province has been analyzed. Results: During years 1994-1998, total of 636 patients have been diagnosed, 40% female and 60% male. 83% of female patients had BCC and 17% had SCC. 71.5% of male patients had BCC and 26.5% had SCC. BCC to SCC ratio in male and female patients were 2.7 and 5 respectively, and 3.4 in whole. In both sexes the most common age of the diagnosis was the seventh decade. Most of the patients had outdoor occupations. Conclusion: The results of this study indicate that NMSC is more common in male who have outdoor occupations and proper education and protective measures for individuals at high risk must be considered.
G Sadeghian; MA Nilforoush Zadeh
Volume 9, Issue 1 , 2006, , Pages 17-21
R Yaghoobi; N Hoghooghi Rad
Volume 1, Issue 1 , 1997, , Pages 19-23
Abstract
Cutaneous leishmaniasis is a parasitic infection prevalent in many areas. The parasitic agent is usually transmitted by Phlebotomous sp. Lip leishmaniasis is a type of cutaneous leishmaniasis, which has rarely been reported. In a retrospective study performed in Ahwaz, center of Khuzestan province, southwest ...
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Cutaneous leishmaniasis is a parasitic infection prevalent in many areas. The parasitic agent is usually transmitted by Phlebotomous sp. Lip leishmaniasis is a type of cutaneous leishmaniasis, which has rarely been reported. In a retrospective study performed in Ahwaz, center of Khuzestan province, southwest of Iran, 2861 patients were detected during 1986-1996. Seventeen of these patients (0.59%) had lower or upper lip leishmaniasis. The patients, age ranged from 3 months to 40 years. Duration of infection was 2 to 4 months. Eleven patients had only lip lesions whereas 6 patients had one or more skin lesions elsewhere. The appearance of lesions differed from nodules to crusted ulcers, usually observed on the vermilion border. Most of the cases failed to respond to topical or systemic antibiotic therapy. The diagnosis was based on the demonstration of Leishman bodies in Giemsa stained smears.
A Moin; N Fallah
Volume 2, Issue 2 , 1999, , Pages 20-25
Abstract
Nails can act as a protective, defensive and beauty cover of the phalanges. The dermatologic disorders as well as the systemic diseases and trauma can produce change in the nails. Normal variations of nails are important to recognize and distinguish from nail diseases. There is not enough information ...
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Nails can act as a protective, defensive and beauty cover of the phalanges. The dermatologic disorders as well as the systemic diseases and trauma can produce change in the nails. Normal variations of nails are important to recognize and distinguish from nail diseases. There is not enough information about the prevalence of nail disorders in children. In this study, we have determined the prevalence of leukonychia, pitting and koilonychia in Tehran elementary schools. Examinations were conducted among 1902 elementary students and leukonychia in 16.9%, pitting in 2.1% and koilonychia in 1.8% were found. There was no difference in the overall frequency of the nail disorders between males and females. The prevalence of leukonychia and pitting was more frequent in the 5th grade than first grade and in 11th educational area of the education ministry. There was not any important relation between the nail disorders and dermatologic disorders or systemic diseases, trauma may be the most important factor in these nail disorders. As regards to the importance of diagnosing the hypochromic anemia and cystine deficiency, we suggest a scientific research about koilonychia and those disorders.
Ch Chams; F Davachi; F Shahram; M Akbarian; F Gharibdoost; AH Nadji; AR Jamshidi; H Chams
Volume 1, 3-4 , 1998, , Pages 23-28
Abstract
Background: There is not yet a pathognomonic laboratory test for the diagnosis of Behcet’s Disease (BD). The diagnosis is therefore based on clinical manifestations. Mucocutaneous lesions are the most important and the most frequent clinical manifestations of BD. Objective: To study the mucocutaneous ...
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Background: There is not yet a pathognomonic laboratory test for the diagnosis of Behcet’s Disease (BD). The diagnosis is therefore based on clinical manifestations. Mucocutaneous lesions are the most important and the most frequent clinical manifestations of BD. Objective: To study the mucocutaneous lesions systematically. In a great number of patients. Some of these clinical pictures are poorly defined in the literature, and some of them are still unknown. Methods: From 1992 to 1998 we screened systematically all patients attending the Behcet’s Disease Research Unit (BDRU), Rheumatology Research Center, Tehran University for Medical Sciences, for mucocutaneous lesions. Only recurrent lesions were taken in consideration. A total of 3751 patients were seen and registered in our database. The mean number of new patients seen every year, during the last 10 years, was 302 patients per year. Results: Besides the classical lesions, we observed unusual and rare forms of mucous membrane, cutaneous, and subcutaneous lesions. Mucous Membrane lesions: 1) Oral aphthosis is the most important lesion of BD (96.1%±0.6). They are not different from other aphthosis, but they are often smaller. There are also the Punctiform, the Miliaria, and the Herpetiform aphthosis. 2) Genital aphthosis was seen in 63.9%±1.5 of patients. In females they are often larger, deeper, and very painful. Giant forms are seen sometimes. In male they are seen more often on the scrotum. Recurrent conjunctival aphthosis is rare. It is small and ephemera. 3) Ulceration and erosions are different from aphthous lesions. They can take multiple and various shapes without a specific characteristic. 4) Purpura and erythema may also be seen on the mucous membrane. Skin Lesions: Is the second most frequent manifestation of BD. It was seen in 67.4%±1.5 of the patients. The pathergy phenomenon, which is a skin hyper reactivity to trauma, was seen frequently in BD. The most important cutaneous lesions of BD is the pseudo folliculitis. It is a small erythematous lesion, surmounted in the center by a round and non-acuminated pustule, which is dome shaped, sterile, and without hair in the center. They are situated mainly on the lower limbs. Other lesions are 1) Small round erythemato-edematous lesions. 2) Cutaneous aphthosis, which is the most characteristic lesion of BD. It is a round and punched out ulceration with a white yellowish necrosis on the bottom. It leaves a scar after healing. 3) Small nodules. 4) Behcet’s Cellulitis; it is a large painful erythematous lesion. It is not infectious nor a superficial thrombophlebitis. In the literature, it was mistakenly taken as Sweet syndrome. The biopsy in all lesions shows a vasculitis, leucocytoclastic or lymphocytic. Subcutaneous Lesions: Erythema nodosum is seen in 22.8%±1.3 of cases. It is a frequent and relapsing lesion. It is a subcutaneous node, painful, red mauve, with different sizes, and often surrounded with an erythematous and edematous ring. Other lesions are rarely seen 1) Subcutaneous lesions, like Erythema Induratum of Bazin. 2) Suppurative panniculitis. Conclusion: Our study showed a wide variety of muco-cutaneous lesions. The lesions are not specific of BD, but they have their own characteristic. Those characteristics, along with the coexistence of different forms, can help to diagnose BD.
Barzegar Mohammadreza; Golfeshan Atefe
Volume 19, Issue 75 , 2016, , Pages 32-34
Supreeti Biswas; Kanchan Kumar Mondal; Indranil Saha; Rathindra Nath Dutta; Saibendu Kumar Lahiri
Volume 13, Issue 2 , 2010, , Pages 37-41
Abstract
Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study ...
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Introduction: Acne vulgaris is a frequently encountered skin disease in daily practice. Its clinico-epidemiological status was evaluated in this study.Methods: Four hundred patients were studied by record-based observation for 2 years in the Acne Clinic of a tertiary care hospital.Results: This study revealed a male preponderance (53%) with a higher prevalence in adolescents (75%). Women with a regular menstrual cycle had a lower acne grading (ρ = – 0.31). Increased physical activity led to a decrease in acne grading (ρ = – 0.20). An association was found between acne and family history (42%) and nonvegetarian, oily, spicy fast food (99%). Our prescribed allopathic treatment in the Acne Clinic showed improvement. No drug induced ocular toxicity was observed. Hot, humid, dusty environment influenced the majority (87%) of the respondents. Urbanization (69%) increased the occurrence of acne.Conclusion: Community based studies are required to find out the actual burden of acne vulgaris.
Shahidi-Dadras Mohammad; Namazi Nastaran; Khalilazar Sara; Younespour Shima
Volume 15, Issue 2 , 2012, , Pages 38-41
Abstract
Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. ...
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Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. The aim of this study was to evaluate the essential metals in psoriasis in comparision with healthy controls. Method: We investigated serum levels of zinc, copper, and magnesium in 40 psoriatic patients and age and sex matched controls. Result: Psoriatic patients showed significantly higher serum levels of copper / zinc and lower magnesium in comparison with the control group. No significant differences were seen in copper and zinc levels. There was no correlation between serum levels of these elements and psoriasis severity except for zinc; the serum level of zinc was inversely correlated with psoriasis severity. Conclusion: This study demonstrated some disturbances in serum levels of metals in psoriasis. More studies are required to clarify the importance of these findings in etiopathogenesis or treatment.
Rezazadeh Fahimeh; Salah Shilan; Bahareh Nazemi Salman; Ebrahim Shahdadi
Volume 19, Issue 2 , 2016, , Pages 40-44
Abstract
Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. ...
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Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. Methods: We conducted this prospective screening study on 50 patients with RAS and 50 controls. Both groups received a questionnaire and underwent serum screening for detection of blood t
Azam Jah Samdani; Bahram Khan Khoso
Volume 12, Issue 2 , 2009, , Pages 42-46
Abstract
Background: Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which ...
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Background: Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which 40 children and adults with albinism live. The aim of this study was to observe the pattern of inheritance, complications and socioeconomic impacts of this condition on the community.Methods: Detailed clinical history and relevant data were recorded on a specially designed performa followed by clinical examination by a consultant dermatologist together with his team to observe the extent of the disease and associated complications in two seasons (winter and summer).Result: This village, with a total population of 810, had 40 cases, 17 male and 23 female, ranging in age from 6 months to 35 years. About 65% of the affected individuals were younger than 16 years of age. There were 22 involved families in this village and 2 of them had 3 or 4 affected members. In this area, which is geographically close to the equator, all 40 cases (100%) had photodermatosis and 36/40 cases (90%) had bacterial skin infections during summer. In addition, they had limited outdoor exposure during this season. These complications also caused occupational, social and educational limitations 9 months a year. Eye problems were present in all 40 cases; however, all 40 cases were malignancy free.Conclusion: Oculocutaneous albinism is challenging not only because of its management but also because of its social and financial impacts. The current trend of consanguineous marriages, prevalent in this village, puts further emphasis on the role and the importance of marriage counseling in such situations.
