Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Leptin and sex hormones in psoriasis and correlation with disease severity434898225ENTehranchinia ZohrehNiroomand MahtabKazeminejad ArmaghanGhahari Mohammad JafarRadvar Siamak EsmaeiliSadat-Amini Seyed HadiYounespour ShimaPartovi-Kia MasoudJournal Article19700101Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determine the serum levels of leptin and sex hormones inpatients and their association with disease severity.Method: This cross-sectional study included 43 male patientswith psoriasis and 42 age- and sex- matched healthy controls. Wemeasured serum levels of leptin, sex hormone-binding globulin(SHBG), luteinizing hormone (LH), follicle stimulating hormone(FSH), prolactin, and total testosterone in both groups.Result: Psoriatic patients had siIranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Comparison of patch testing results between job related and non job related allergic contact dermatitis in Iran495398226ENNassiri-Kashani MansourNassiri-Kashani Mohammad HassanKhatami Alireza0000-0002-4175-5775Ghafari MostafaFirooz AlirezaDowlati YahyaJournal Article19700101Background: Job-related allergic contact dermatitis (ACD) mayprolong the disease duration, increase disabilities, and decreasethe patient’s quality of life. The aim of this study was to determinecommon allergens causing ACD, investigating certain featuresof the disease and evaluating its relation to the patients’ jobs.Method: In this cross-sectional study, relevant data was obtainedfrom patch test clinics at the Center for Research and Trainingin Skin Diseases and Leprosy, Tehran University of MedicalSciences, and two private dermatology clinics in Tehran, Iran.Nine hundred and forty six patients from different regions of Iranwith a probable diagnosis of ACD were recruited into the study.Patch testing was used as the gold standard test to differentiateACD from other differential diagnoses.Result: Of 946 studied patients with a probable diagnosis ofACD, 649 (68.6%) cases were females. The mean age ± standarddeviation (SD) of the patients was 31.9 ± 12.3 years. Five hundredand twenty eight (55.7%) cases had positive patch test results toat least one tested allergen. Comparing job-related and non jobrelatedACD patients revealed that while there was a significantdifference in the mean age of the two group (30.6 ± 11.3 vs.32.7 ± 12.9 years in job-related and non-job-related groups,respectively) (P=0.016), there were no significant differences inthe gender distribution, number of positive patch tests, frequencyof allergens, reaction time, and severity of reactions between thetwo groups. Nickel sulphate and cobalt chloride were the twomost common allergens in both groups.Conclusion: Job-related patients were younger and most of themwere female compared to non job-related patients. However,other characteristics were not different between the two groups.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Methicillin-resistant Staphylococcus aureus (MRSA) an important microorganism: determination of its prevalence and evaluation of its associated factors in hospitalized dermatologic patients545898227ENAlizadeh NargesOskuee Alireza Ba–EemanGolchai JavadSadre-Eshkevari ShahryarDarjani AbbasKazemnejad EhsanEftekhari HojatMohtasham-Amiri ZahraJournal Article19700101Background: Methicillin–resistant Staphylococcus aureus (MRSA)has recently emerged as a worldwide major nosocomial pathogenthat causes significant morbidity and mortality. MRSA is frequentlycolonized on the skin. The aim of this study was to determinethe MRSA colonization/infection prevalence and to evaluatethe potential risk factors for its development in the hospitalizedpatients in a referral dermatology ward.Method: In this cross sectional study, 203 patients with cutaneouslesions who were admitted to the dermatology ward of a tertiaryteaching hospital from 2008 to 2010 were recruited. Sampleswere collected during the first 48 hours of admission. S. aureuswas identified using gram staining, catalase, and coagulase tests.The disk diffusion method was used for testing the sensitivityof different bacteria to antibiotics. Mueller-Hinton agar was theculture medium used for MRSA susceptibility testing.Result: Staphylococcus. aureus was the most common pathogenthat grew in 56.2% (114/203) of isolates. MRSA was foundin 35.5% (82/203) of isolates. The duration of the cutaneouslesions, age group, positive history of antibiotic use in past 12months, and underlying diseases were statistically differentbetween the patients with colonization of MRSA and methicillinsensitiveStaphylococcus aureus (MSSA) (PIranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Vitamin D serum level in vitiligo patients: A case-control study from Iran596298228ENLajevardi VahidehNazemi Mohammad JavadKhodashenas ZohrehEbadi Mohammad-SadeghJournal Article19700101Background: Generalized vitiligo is characterized by autoimmunedestruction of melanocytes, which results in patches of thedepigmented skin and the overlying hair. Vitamin D is an essentialhormone synthesized in the skin and is responsible for skinpigmentation. Low vitamin D levels have been noted in patientswith a variety of autoimmune diseases. A recent study showedthat low vitamin D levels may be associated with vitiligo. Theaim of this study was to compare 25-hydroxyvitamin D (25[OH]D) levels in Iranian patients with vitiligo with normal controls.Method: In this case-control study, we studied 30 newly diagnosedpatients with vitiligo and 30 healthy controls through a casecontrol design. Two groups were matched for gender, age, andthe season in which the serum levels of 25-hydroxy vitamin Dwere measured. The serum levels were categorized as sufficient,insufficient and deficient.Result: The mean serum level of vitamin D was 10.24±1.27 ng/mL in patients compared to 18.31±7.39 ng/mL in the controlgroup. Male patients had lower levels of vitamin D compared tocontrols (7.25 ng/mL vs. 13.31ng/mL, P=0.03), while no significantdifference was observed between females and controls (14.12 ng/mL vs. 16.25 ng/mL, P=0.51).Conclusion: The present study demonstrated that there may be anassociation between low levels of Vitamin D3 and vitiligo in men.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Basic data of patients with skin drug reactions admitted to Razi Hospital, Tehran, Iran636798229ENEhsani AmirhoushangMortazavi HosseinAzizpour ArghavanAnsari MahsaTeimori EdrisGoodarzi AzadehRahbar ZibaAryanian ZeinabJournal Article19700101Background: Although most cases of drug eruptions are mildand self-limited and are relieved after discontinuation of theresponsible drugs, statistics of life threatening outcomes shouldbe kept in mind. Moreover, it is important to identify the mostcommon age and sex groups, and the most vulnerable groupsin any area related to offending drugs. Thus, we collected thebasic information of patients with skin drug reactions who wereadmitted to Razi Hospital, Tehran, Iran, during 2010-2012 (18months).Method: In this study, all patients with a diagnosis of drugreactions who were admitted to Razi Hospital, Tehran, Iran,during 2010-2012 (18 months) were enrolled. The types of drugsand skin reaction manifestations were reported.Result: One hundred and thirty one patients were admitted witha diagnosis of drug reactions. The mean age of the participantswas 40 years. Forty one patients were male (31.3%) and 90 werefemale (68.3%). Antibiotics and anticonvulsants were the mostcommon drugs associated with reactions. Carbamazepine wasthe most common drug that caused reactions (21 cases, 17.4%)followed by penicillin (20 cases, 16.5%), and lamotrigine (16 cases,13.2%). Morbilliform rash (40 cases, 30.5%), erythroderma (18cases, 13.7%), and urticaria/angioedema (14 cases, 10.7%) werethe most common patterns of skin involvement.Conclusion: The results of our study are consistent with the resultsof other studies. It is recommended that drugs that commonlycause adverse reactions be prescribed with more precautionin females aged 20-40 years, and if possible, be replaced withappropriate drugs. Moreover, it is recommended that patients whoare allergic to these drugs carry a certain card that demonstratestheir sensitivity.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401A case of squamous cell carcinoma of the skin subsequent to a subcutaneous foreign body687198230ENMubashir SyedAnwar ParvaizHassan IffatArif TasleemJournal Article19700101Squamous cell carcinoma (SCC) of the skin is one of the mostcommon non melanoma skin cancers (NMSC), along withbasal cell carcinoma (BCC). Besides ultraviolet radiation,exposure to industrial agents, ionizing radiation, and areas ofchronic inflammation are associated with the development ofSCC. Squamous cell carcinoma may also be associated withforeign bodies. We report a rare case of cutaneous SCC in anelderly Kashmiri female, which was developed subsequent to asubcutaneous non metallic foreign body and was successfullyexcised with negative margins and transposition flap closure.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Case report: sporotrichoid form of lupus vulgaris727598231ENMousumi Roy BandyopadhyayDN GangopadhyaySarkar SomnathBesra MrinalJournal Article19700101Lupus vulgaris, a common form of cutaneous tuberculosis, usuallyhas different patterns including the plaque form, ulcerative andmutilating form, vegetative form, tumor-like form, and papularand nodular form. Lupus vulgaris commonly appears on thenormal skin as a solitary lesion. However, certain uncommonforms are identified that pose a diagnostic dilemma. Sporotrichoidlikespread has been rarely reported. Atypical presentations ofcutaneous tuberculosis are not very uncommon but are frequentlyoverlooked in the clinical practice, leading to a late diagnosisand increased morbidity. We report two cases of lupus vulgariswith a sporotrichoid pattern. Our patients presented with thecharacteristic morphologic features of lupus vulgaris (LV) ina different distribution pattern. The diagnosis was supportedby laboratory investigations, histopathological examination,and an excellent response to antitubercular therapy. Bothcases demonstrated a linear arrangement of lesions mimickingsporotrichosis. We emphasize that cutaneous tuberculosis canoccur in an unusual form in an immunocompetent person. Theaim of this communication is to bring this often overlooked butdefinitely curable clinical entity to attention.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Focal epithelial hyperplasia (Heck’s disease): a case report from Iran767899632ENGholamreza EshghiLeila KhezrianAlireza Ghasemi-BasirHeshmat-allah Babaee-KiadehiJournal Article20191225Focal epithelial hyperplasia or Heck’s disease is a benign, rare viral disease of the oral cavity and is associated with human papillomavirus 13 and 32 (HPV-13 and HPV-32). Most patients are children but adults may also be at risk. Clinically, the patients have multiple small white or pink papules on the mucosal surface of the lips, buccal mucosa and the tongue. In Iran, this disease seems to be rare. Herein, we describe an adult Iranian case of focal epithelial hyperplasia.Iranian Society of DermatologyIranian Journal of Dermatology2717-072117220140401Post nuclear crisis: what about the mucocutaneous problem?797998232ENJoob BeuyWiwanitkit VirojJournal Article19700101Health problems after a nuclear crisis are aninteresting issue in medicine. After the recentJapanese nuclear crisis, several health issuesunderwent monitoring. There are few considerationson mucocutaneous diseases. Indeed, there is nodoubt that the skin and mucocutaneous issues arethe main organs affected by leaked radiations. It isimportant to take care of mucocutaneous lesionsin acute radiation syndrome.