Original Article
Kuppusamy Meera; Taib Tarita binti; Asmah Johar; Abdul Manan bin Mat Jais
Volume 19, Issue 3 , 2016, Pages 67-72
Abstract
Background: Channa striatus or better known as the haruan fish is an indigenous, snakehead, striped, air breathing freshwater fish of Malaysia and has long been consumed traditionally during post-operative and post-partum period to speed recovery. Most medical properties of the haruan are contributed ...
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Background: Channa striatus or better known as the haruan fish is an indigenous, snakehead, striped, air breathing freshwater fish of Malaysia and has long been consumed traditionally during post-operative and post-partum period to speed recovery. Most medical properties of the haruan are contributed to its high content of essential fatty and amino acids. This was a phase I clinical trial to examine the safety of Channa striatus (CS) 5% cream with patch testing and cumulative dosing for up to 4 weeks on the healthy skin. Methods: This double-blind randomized controlled trial was conducted in two stages. Eighty-three participants who fulfilled the inclusion criteria underwent patch testing. The allergens, aqueous and CS 5% cream, were patch tested simultaneously but separately on each arm of the same participant. The participants with a negative patch test started stage 2, whereby they applied randomly assigned creams on both forearms for a duration of 1 month. Results: A total of 83 participants were screened successfully and underwent patch testing. One participant in the cohort developed a positive patch test to CS 5% and was excluded from stage 2. Two participants experienced mild side effects that resolved with mild topical steroid. The incidence of allergic contact dermatitis and irritant contact dermatitis was 1.2% and 2.4% in the participants, respectively. Conclusion: The uniquely Malaysian Channa striatus 5% cream has a good safety profile. Information on the safety and tolerability obtained from this study can be used to design larger phase II studies in patients with inflammatory skin conditions.
Original Article
Alhumidi Ahmed Abdullah; Fahad Mohammed Alsaif
Volume 19, Issue 3 , 2016, Pages 73-78
Abstract
Background: Pregnancy-specific dermatoses represent a group of pruritic skin diseases unique to pregnancy and the most common types are polymorphic eruption of pregnancy and pemphigoid gestationis. It is difficult to obtain a histopathological diagnosis for polymorphic eruption of pregnancy and pemphigoid ...
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Background: Pregnancy-specific dermatoses represent a group of pruritic skin diseases unique to pregnancy and the most common types are polymorphic eruption of pregnancy and pemphigoid gestationis. It is difficult to obtain a histopathological diagnosis for polymorphic eruption of pregnancy and pemphigoid gestationis in the lack of immunofluorescence because of their similar clinical presentation, particularly in the absence of bullous eruptions. We assessed the potential correlation between cellular cutaneous infiltration and a diagnosis of polymorphic eruption of pregnancy or pemphigoid gestationis. Methods: This retrospective analysis was conducted at King Khalid University Hospital (Riyadh, Saudi Arabia) using biopsybased data collected from 1999–2014. The study group included 29 patients with polymorphic eruption of pregnancy and 24 patients with pemphigoid gestationis. Results: Three skin biopsy reports were excluded due to a strong history of atopy to rule out any possibility of atopic eruption of pregnancy. We performed a histopathological study of 50 patients. The data analysis revealed significant eosinophilic cell infiltration along the dermoepidermal junction and the tagging of eosinophils along the basal layer in biopsies from pemphigoid gestationis. Conclusion: We observed significant eosinophilic cell infiltration along the dermoepidermal junction and the tagging of eosinophils along the basal layer, which may support a diagnosis of pemphigoid gestationis in the absence of direct immunofluorescence.
Original Article
Jeelani Shazia; Lanker Audil; Jeelani Nasir; Masood Qazi; Fazili Tawheeda; Majid Huma
Volume 19, Issue 3 , 2016, Pages 79-85
Abstract
Background: Onychomycosis (OM) is the infection of nails caused by a variety of fungi. As systemic antifungal treatment is necessary in the majority of patients, appropriate diagnostic techniques are important to ensure a correct diagnosis and treatment. Objective: This study was carried out to evaluate ...
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Background: Onychomycosis (OM) is the infection of nails caused by a variety of fungi. As systemic antifungal treatment is necessary in the majority of patients, appropriate diagnostic techniques are important to ensure a correct diagnosis and treatment. Objective: This study was carried out to evaluate the clinical, mycological, and histological aspects of onychomycosis in detail. Methods: A cross-sectional study was carried out on 216 patients with a high degree of clinical suspicion for OM. Clinical details including the site, morphological type, and associated diseases were noted in each case. The specimens obtained were subjected to three diagnostic tests: direct microscopy, fungal culture, and histopathological examination using PAS staining. Results: OM was more common in young adults in the age group 20-40 years (40.2%). In the majority (46.3%) of the cases, the duration of the disease was ≤ 1year. Distal and lateral subungual onychomycosis was the most common (73.6%) clinical type. A high incidence of toe nail onychomycosis (68.5%) was noted in our study. Dermatophytes were the most common etiological agent. Among the dermatophytes, Trichophyton mentagrophytes was the most common isolated fungus. Histopathological examination using PAS staining (HPE-PAS) showed the highest sensitivity of 91.6% among the three tests. Conclusion: Dermatophytes are the main agents responsible for OM in this region with T. mentagrophytes being the most common isolate. This study also demonstrated the importance of performing routine histopathology in addition to direct examination and culture for the diagnosis of onychomycosis.
Original Article
Kamyab Kambiz; Firooz Alireza; Kohsari Laleh Montaser; Noorian Negin; Khorshid Hamidreza Khorram; Khatami Alireza; Estarabadi Ali Rajabi
Volume 19, Issue 3 , 2016, Pages 86-88
Abstract
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment ...
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Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sarcoidosis in comparison with skin sarcoidal reaction patients and those with normal skin. Methods: The nucleotide sequence of rs2076530 allele in exon 5 of BTNL2 gene was compared among the paraffin-embedded blocks of 34 patients with a histologic diagnosis of sarcoidosis, 14 patients with skin sarcoidal reaction (tattoo, foreign body), and 27 patients with normal skin (excised during cosmetic surgery) using polymerase chain reaction. Results: There was no statistically significant difference in the frequency of 3 genotypes of AA, AG, and GG in rs2076530 allele among skin sarcoidosis, skin sarcoidal reaction, and normal skin. Conclusion: The expression of rs2076530 allele of BTNL2 gene in skin sarcoidosis or sarcoidal reaction does not differ with its expression in the normal skin.
Original Article
Tabari Soudabeh Tirgar; Barat Shahnaz; Shakerian Mohammad Ali; Hashemi Kamal; Saeedi Fayyaz
Volume 19, Issue 3 , 2016, Pages 89-92
Abstract
Background: Genital warts are one of the most common viral sexually transmitted diseases in the world. They are caused by different human papilloma viruses and lesions may have benign to malignant transformation. The main purpose of this study was to determine the prevalence of condyloma acuminata in ...
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Background: Genital warts are one of the most common viral sexually transmitted diseases in the world. They are caused by different human papilloma viruses and lesions may have benign to malignant transformation. The main purpose of this study was to determine the prevalence of condyloma acuminata in the spouses of patients with genital warts. Methods: This cross-sectional study was done on 153 patients with genital warts and their spouses who were referred to dermatology and gynecology clinics of Babol University of Medical Science (North of Iran) between 2009 and 2012. All cases were clinically examined by dermatologists and gynecologists. After obtaining consent, the data including patients’ sex and age, genital wart in the spouse, history of warts in other sites of the body, positive family history of all forms of warts, smoking, addiction, alcohol consumption, and OCP use were collected via a questionnaire and analyzed with t and chi-square tests. P values less than 0.05 were considered significant. Results: In this study, 100 (65.4%) patients were women and 53 (34.6%) were men. Genital warts were detected in 25.5% of the spouses. The mean age of the patients and their spouses was 30.2±8.7 and 31.5 ±7.4 years, respectively. There was no significant correlation between age and genital wart in the spouse. Conclusion: The results showed that genital warts are a relatively highly infectious disease. Our recommendation for prevention of genital warts is education and clinical examination of the patients’ spouses.
Case Report
Bains Pooja; Mittal Jyotisterna
Volume 19, Issue 3 , 2016, Pages 93-96
Abstract
A 26-year-old married female presented with a complaint of recurrent multiple ulcerative lesions on her body. After complete history and physical examination, a diagnosis of dermatitis artefacta was made. Dermatitis artefacta remains undiagnosed for quite some time because of its atypical skin changes, ...
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A 26-year-old married female presented with a complaint of recurrent multiple ulcerative lesions on her body. After complete history and physical examination, a diagnosis of dermatitis artefacta was made. Dermatitis artefacta remains undiagnosed for quite some time because of its atypical skin changes, diverse methods used for producing skin lesions, lack of awareness about the disorder on the part of physicians, nonspecific histology, and normal blood tests. An early and correct diagnosis is helpful in avoiding unnecessary investigations, and allowing better patient management. In this particular case, there were three important clues (medical history, morphology of the lesions, and the patient’s behavior) which paved the way for an early diagnosis of this rather puzzling and rare disorder.
Case Report
Rafiei Rana; Eftekhari Hojat; Granmayeh Siamak; Shafaei Sareh
Volume 19, Issue 3 , 2016, Pages 97-100
Abstract
Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is histologically characterized by atypical T lymphocytes with cerebriform nuclei that infiltrate the epidermis. Alope
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Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is histologically characterized by atypical T lymphocytes with cerebriform nuclei that infiltrate the epidermis. Alope
Quiz
Saki Nasrin; Aslani Fatemeh Sari; Brojeni Nahid Hemmatian; Bahraminia Sahar
Volume 19, Issue 3 , 2016, Pages 101-103
Abstract
A 52-year-old woman sought medical attention because of several annular erythematous lesions with central clearing on her body since seven months ago. No pruritus or burning sensations were noted. Her medical and family history was unremarkable. Her Fitzpatrick skin photo-type was II. On dermatological ...
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A 52-year-old woman sought medical attention because of several annular erythematous lesions with central clearing on her body since seven months ago. No pruritus or burning sensations were noted. Her medical and family history was unremarkable. Her Fitzpatrick skin photo-type was II. On dermatological physical examination, there were several annular erythematous plaques with raised borders and central clearing on dorsal aspect of her hands, wrists, forearms, and neck. General physical examination was unremarkable. An incisional skin biopsy was done from one of her lesions including the normal skin, border, and center of the lesion. Histological examination showed intact epidermis, and infiltration of histiocytes and multinucleated giant cells centered in the mid dermis. There were areas of almost complete loss of elastic fibers surrounded by histiocyte aggregates. There was also mild to moderate mainly lymphocytic infiltration around the vessels. Mucin deposition was not seen .
