Banihashemi Mahnaz; Nahidi Yalda; Meibodi Naser Tayyebi; Jarrahi Lida; Livani Fatemeh; Seifnia Sahar
Abstract
Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with ...
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Background: Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. Because vitamin D deficiency is associated with many immune disorders, we compared the levels of vitamin D between PV patients and healthy controls. Methods: Vitamin D level of 20 patients with PV was compared with 20 healthy individuals matched for age, gender, hours spent in the sun, body mass index (BMI) and daily vitamin D intake at the same time interval. The severity of the disease was estimated according to ABSIS score. The serum level of 25-hydroxyvitamin D (25OHD) was measured by a commercial ELISA test. Results: Vitamin D deficiency in the pemphigus vulgaris group (75%) was higher than healthy controls (45%) (P = 0.053). Mean level of vitamin D in PV patients was significantly lower than healthy controls, and was in the range of vitamin deficiency (P ? 0.05). No significant relationship was observed between the severity of the PV disease and vitamin D levels (P > 0.05). Conclusions: Based on the results of the present study, the mean level of vitamin D in patients with PV was significantly lower than healthy people. Based on our findings and given the important role of vitamin D in preventing inflammatory and autoimmune diseases, vitamin D deficiency can be considered as a factor triggering the onset of PV.
Banihashemi Mahnaz; Mohammad Javad Yazdanpanah; Soleiman Nouri; Sarah Hashemzadeh
Volume 19, Issue 4 , 2016, , Pages 136-138
Abstract
The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the conceptof granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors.Herein, we describe a 54-year-old ...
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The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the conceptof granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors.Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to conventional treatment and was followed by breast cancer. Only two cases of granuloma annulare and breast cancer have been reported so far in the literature. We believe that these cases emphasize on considering granuloma annulare as a possible paraneoplastic dermatoses.
Banihashemi Mahnaz; Meibodi Naser Tayebi; Kardan Golsan
Volume 18, Issue 2 , 2015, , Pages 71-73
Abstract
Juvenile xanthogranuloma (JXG) is an uncommon histiocytic cutaneous lesion. It is a type of non-Langerhans cell histiocytosis(WHO Class IIb). The mean age of onset is 2 years of age. The adult form of JXG is relatively rare. The most common affectedarea is the face or the scalp and most of the lesions ...
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Juvenile xanthogranuloma (JXG) is an uncommon histiocytic cutaneous lesion. It is a type of non-Langerhans cell histiocytosis(WHO Class IIb). The mean age of onset is 2 years of age. The adult form of JXG is relatively rare. The most common affectedarea is the face or the scalp and most of the lesions are less than 5 mm in diameter. This lesion tends to show a self-limited course over several months to years. However, large size JXG can have an atypical course or create cosmetic problems. Therefore,excision is considered in such lesions. We report an adult form of JXG that presented as an asymptomatic solitary tumor witha rapid growth on the nose of a 16-year-old boy. Routine microscopic histopathological evaluation of the patient’s skin biopsy showed numerous eosinophils and Touton giant cells. Immunohistochemical evaluation was positive for CD68 and factor XIIIa. We performed extended excision to prevent recurrence and the tumor did not recur after resection.
Banihashemi Mahnaz; Javidi Zari; Khani Fatemeh; Ghiasi-Moghadam Taghi; Ghaffarzadegan Kamran; Hashemzadeh Sara
Volume 17, Issue 4 , 2014, , Pages 122-125
Abstract
Background: Pityriasis rosea (PR) is a common papulosquamousskin disorder that is suspected to have an infectious etiology.We aimed to study the role of human herpesvirus-6 (HHV-6) inthe pathogenesis of PR.Method: We used immunohistochemical (IHC) assays to detectHHV-6 in patients with PR. Fifty-one ...
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Background: Pityriasis rosea (PR) is a common papulosquamousskin disorder that is suspected to have an infectious etiology.We aimed to study the role of human herpesvirus-6 (HHV-6) inthe pathogenesis of PR.Method: We used immunohistochemical (IHC) assays to detectHHV-6 in patients with PR. Fifty-one patients with PR and 35 ageand sex matched healthy control samples were enrolled in thestudy. The intensity and percentage of cell staining for HHV-6infection were evaluated and recorded.Result: The intensity of IHC staining was negative in 25 (49.01%)patients and 24 (68.58%) control samples while it was +1 in 6(11.77%) patients and 11 (31.42%) control samples, +2 in 4 (7.85%)patients and +3 in 16 (31.37%) of them. The incidence of moderateand intense staining for HHV-6 was significantly higher amongpatients with PR than the control group (P value < 0.01).Conclusion: We concluded that HHV-6 infection may play arole in some patients with PR. The rate of HHV-6 infection wassignificantly higher in PR patients than the control group.
Banihashemi Mahnaz; Pezeshkpoor Fakhrozaman; Hadis Yousefzadeh; Fatemeh Livani; Gholamreza Ghandeharian
Volume 17, Issue 4 , 2014, , Pages 126-129
Abstract
Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral ...
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Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to be infected with this virus.Method: Materials obtained from a fresh vesicle were used toprepare Tzanck smears and viral cultures.Result: In this study, 40 (71.4%) of the 56 samples were culturepositive while Tzanck smears were positive in 36 (64.3%) patients.We found that the sensitivity and specificity of the Tzanck testwas 90% and 100% respectively when compared to cell culture.Moreover, the positive predictive value (PPV) and negativepredictive value (NPV) of the Tzanck test was 100% and 80%,respectively.Conclusion: The Tzanck smear has its limitations but is still asuitable rapid, easy, and cost effective diagnostic method forherpes simplex virus infections, especially when viral cultureor other virological methods are not available.
Banihashemi Mahnaz; Fazel Zahra; Meibodi Naser Tayyebi; Imani Mohammad; Zabolinejad Naghmeh
Volume 16, Issue 1 , 2013, , Pages 42-44
Abstract
A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.
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A 38- year-old man in good general health and normal intellectualfunctioning referred to the dermatologic clinic with numerouspruritic reticulate pigmentations on his neck, chest and upperback since 10 years ago. We noticed similar lesions on his axillae,groin and infra mammary area with no family background.