Abedini Robabeh; Lajevardi Vahideh; Hallaji Zahra; Khodashenas Zohre; Zafar Fatemeh; Nasimi Maryam
Volume 19, Issue 4 , 2016, , Pages 113-118
Abstract
Background: Psoriasis is a chronic skin disorder that can significantly affect a patient’s quality of life (QoL). The goal of this study was to determine the QoL in patients with psoriasis and to investigate the correlation between the QoL, demographic data, and clinical severity of psoriasis.Methods: ...
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Background: Psoriasis is a chronic skin disorder that can significantly affect a patient’s quality of life (QoL). The goal of this study was to determine the QoL in patients with psoriasis and to investigate the correlation between the QoL, demographic data, and clinical severity of psoriasis.Methods: This prospective, cross-sectional study was conducted from April 2014 to January 2015. One hundred patients with plaque type psoriasis from the Phototherapy Clinic of Razi Hospital, Tehran, Iran were selected and asked to complete questionnaires. The Psoriasis Area Severity Index (PASI) to measure the severity of psoriasis, and the Dermatology Life Quality Index (DLQI) was used for the assessment of the quality of life.Results: The total DLQI score of the all participants was between 0 and 29 with a mean score of 10.6 ± 6.4. The DLQI scores ranged from “very large” to “extremely large” in 45% of the patients. The mean score was 9.2 ± 6.6 in the male group and 12.1 ± 5.9 in the female group, which showed a statically significant difference (P=0.02). Other variables associated with an impaired QoL were age (P=0.002) and PASI (P=0.01). The impact on QoL was higher in younger patients, and in patients with higher PASI scores.Conclusion: In conclusion, although psoriasis is a benign disorder, this study confirms our initial hypothesis that psoriasis significantly impairs the QoL, which is more pronounced in younger patients, women, and patients with a more severe disease (higher PASI scores).
Ghandi Narges; Tavassoli Shaghayegh; Ghiasi Maryam; Lajevardi Vahideh; Abedini Robabeh; Tohidinik Hamid-Reza; Daneshpazhooh Maryam
Volume 19, Issue 75 , 2016, , Pages 35-13
Abstract
Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation ...
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Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation with disease type and severity. Methods: In this cohort study, we measured serum PRL levels by enzyme-linked immunosorbent assay (ELISA) in newly diagnosed PV patients at three time points: before therapy initiation and after two and four months. Concomitantly, we estimated disease severity by the Pemphigus Disease Area Index (PDAI). Results: We examined 42 new cases of PV. Among 32 cases who completed the study, mean serum PRL levels at the three time points were 15.9±14.1 ng/mL (before treatment), 16.7±9.8 ng/ mL (2 months after initiation of treatment), and 15.2±9.2 ng/mL (4 months after initiation of treatment). Mean PDAI values were 19.3±12.8 (before treatment), 3.7±6.2 (2 months after initiation of treatment), and 0.6±1.5 (4 months after initiation of treatment). Although the disease activity decreased significantly (P
Ghandi Nargess; Abedini Robabeh; Lajevardi Vahide; Nikoo Azita
Volume 11, Issue 1 , 2008, , Pages 42-43
Abstract
A 55-year-old woman was referred to our outpatient clinic because of bilateral papular lesions on her nose from 2 years ego. In clinical examination, we found three symmetrical dome-shaped, skin-colored, asymptomatic papules on both nasal alas. The lesions made the patient's nose to seem larger with ...
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A 55-year-old woman was referred to our outpatient clinic because of bilateral papular lesions on her nose from 2 years ego. In clinical examination, we found three symmetrical dome-shaped, skin-colored, asymptomatic papules on both nasal alas. The lesions made the patient's nose to seem larger with eroded edges (figures 1, 2). Examination of nasal mucosa was normal. General physical examination was unremarkable. A biopsy was done from the lesion (figure 3).