Seirafi Hassan; Fateh Soheil; Farnaghi Farshad; Ehsani Amir Hooshang; Noormohammadpoor Pedram
Volume 13, Issue 1 , 2010, , Pages 1-5
Abstract
Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to ...
Read More
Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to evaluate the efficacy and safety of cryotherapy in comparison with 595-nm pulsed dye laser (PDL) with cutaneous compression in the treatment of solar lentigines. Method: Twenty two patients (skin type II- IV) with facial or hand lentigines completed this study. Lesions of one side of the face or each hand were randomly assigned and treated with either cryotherapy or PDL. Treatments were performed with radiant exposures of 10 J/cm2, 7mm spot size and 1.5ms pulse duration with no epidermal cooling. Photographs were taken before treatment and one month later. The response rate and side effects were compared. Results: PDL was more likely to produce substantial lightening of solar lentigines than cryotherapy, especially in skin types III and IV (n=8, n=9; P0.05). PIH was only seen in the cryotherapy group. PDL group only showed minimal erythema. No purpura was observed. Conclusion: PDL with compression is superior to cryotherapy in the treatment of solar lentigines in darker skin types.
Seirafi Hasan; Farnaghi Farshad; Shams Negin; Davari Parastoo; Gorouhi Farzam
Volume 11, Issue 4 , 2008, , Pages 156-158
Abstract
Background: Inpatient therapy in dermatology offers a number of advantages in several ways i.e. careful monitoring of patients’ conditions, improvement of their skin lesions under the supervision of trained staff, absence of domestic pressure and increasing the quality of patients’ life index. ...
Read More
Background: Inpatient therapy in dermatology offers a number of advantages in several ways i.e. careful monitoring of patients’ conditions, improvement of their skin lesions under the supervision of trained staff, absence of domestic pressure and increasing the quality of patients’ life index. The objective of this study was to describe the patterns of admission for patients with dermatological diseases in Iran Methods: In this retrospective study, data were collected by completing a questionnaire for 481 patients admitted to Razi skin hospital in Tehran during 18 months. Results: The mean age of admitted patients was 44.03 years ± 19.15. Bullous diseases (39.92%), psoriasis (20.79%), dermatitis (9.56%) and neoplasms (6.65%) were found as the most common reasons for admission. The mean duration of hospitalization was 22.79 days and neoplasms had the highest mean hospitalization period. Conclusions: Patient's admission patterns differ from country to country and there should be prioritizing plans to reach better results.
Seirafi Hassan; Farahani Farzaneh; Farnaghi Farshad; Ehsani Amirhooshang; Hashemi Pantea; Farahani Amir
Volume 11, Issue 1 , 2008, , Pages 1-6
Abstract
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus ...
Read More
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was given to 26 patients with generalized, symmetrical vitiligo three times weekly. Topical calcipotriol cream was only applied on the lesions located on one side of the body. Treatment was continued until cosmetically acceptable repigmentation occurred, but total cumulative dose of NBUVB did not increase from the mean of 113.4 ± 47.0 j/cm. The efficacy of treatment was evaluated by visually scoring the percentage of regimentation of the lesions at 12-session intervals by an investigator unaware of the side of calcipotriol application. Results: The mean daily dose of NBUVB was 1.4 ± 0.6 j/cm. The median number of exposure for initial regimentation was 26.5 (range 14-38) on the side of combination therapy with calcipotriol and 25.3 (range 20-40) on the other side. After 24 sessions of treatment, 14 patients (53.9%) showed minimal to moderate improvement on the calcipotriol treated side as compared to 21 patients ( 80.8 %) on the other side. After 60 sessions of treatment, 16 patients (16.5 %) showed moderate to marked regimentation on the side of combination therapy with calcipotriol as compared to 19 patients (73 %) on the other side.Conclusion: These findings indicate that concurrent use of topical calcipotriol does not enhance the efficacy of NBUVB in the treatment of vitiligo.
Farnaghi Farshad; Seirafi Hassan; Ehsani Amirhooshang; Tork Ali Naser; Yazdanian Shideh; Zarrin-nejad Neda
Volume 10, Issue 2 , 2007, , Pages 94-99
Abstract
Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with ...
Read More
Background and aim: Treatment of resistant warts is a common clinical problem. Immunotherapy with diphenyl cyclopropenone (DCP) as a contact sensitizer has been reported. The objective of this study was to evaluate the efficacy of DCP in refractory warts.Materials and methods: Nineteen patients with refractory warts referred to Razi Hospital in 2004 who had not responded to at least 2 treatment modalities, were sensitized with 2% DCP in acetone.Then treatment was started with application of 1% DCP on plantar warts and 0.2% on other locations.Results: Two patients were not sensitized even after 3 attempts. Three other patients discontinuedtreatment due to side effects (severe eczema and pruritus). Six male and 8 female patients completed the trial, among them,10 (71.5%) showed complete clearance of warts. Side effects reported were: local pruritus (21%), distant eczema (10.5%), local blister (26.3%). The patients received a mean of 5 treatment sessions.Conclusion: Topical immunotherapy with DCP is an effective treatment for refractory warts. Due to high efficacy, no scarring, and being a painless procedure it can be considered as a first line treatment of refractory warts.