Pirouzi Saeid; Zargari Omid; Kamyab Kambiz; Kesty Katarina
Volume 20, Issue 3 , 2017, , Pages 89-92
Abstract
Perforating necrobiosis lipoidica (PNL) is a very rare variant of necrobiosis lipoidica (NL), almost always associated with diabetes. A non-diabetic 43-year-old man referred to us with a gradually enlarging plaque on his forehead. The patient was initially diagnosed with cutaneous tuberculosis based ...
Read More
Perforating necrobiosis lipoidica (PNL) is a very rare variant of necrobiosis lipoidica (NL), almost always associated with diabetes. A non-diabetic 43-year-old man referred to us with a gradually enlarging plaque on his forehead. The patient was initially diagnosed with cutaneous tuberculosis based on the histopatholo
Kamyab Kambiz; Firooz Alireza; Kohsari Laleh Montaser; Noorian Negin; Khorshid Hamidreza Khorram; Khatami Alireza; Estarabadi Ali Rajabi
Volume 19, Issue 3 , 2016, , Pages 86-88
Abstract
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment ...
Read More
Background: In 10-30% of the cases with sarcoidosis, skin lesions appear solely without any systemic signs or symptoms. BTNL2 gene, which is a member of the immunoglobulin gene super family and is associated with CD86 and CD80 co-stimulatory receptors, is identified to play an important role in the establishment of sarcoidosis. We aimed to evaluate the role of this gene in patients with skin sarcoidosis in comparison with skin sarcoidal reaction patients and those with normal skin. Methods: The nucleotide sequence of rs2076530 allele in exon 5 of BTNL2 gene was compared among the paraffin-embedded blocks of 34 patients with a histologic diagnosis of sarcoidosis, 14 patients with skin sarcoidal reaction (tattoo, foreign body), and 27 patients with normal skin (excised during cosmetic surgery) using polymerase chain reaction. Results: There was no statistically significant difference in the frequency of 3 genotypes of AA, AG, and GG in rs2076530 allele among skin sarcoidosis, skin sarcoidal reaction, and normal skin. Conclusion: The expression of rs2076530 allele of BTNL2 gene in skin sarcoidosis or sarcoidal reaction does not differ with its expression in the normal skin.
Barzegari Massoume; Valikhani Mahin; Esmaili Nafiseh; Naraghi Zahra; Nikoo Azita; Kamyab Kambiz; Ghanadan Ali; Tamizifar Banafshe
Volume 11, Issue 2 , 2008, , Pages 64-66
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral ...
Read More
Background: Pemphigus vulgaris (PV) is an autoimmune blistering disease, caused by autoantibodies against desmoglein (Dsg) 3 and / or Dsg1 which induce the loss of adhesion between keratinocytes. Nikolsky's sign is the ability to induce peripheral extension of a blister as a consequence of applying lateral pressure to the border of an intact blister. If the weakening of the intercellular adhesion is present but not marked, then the damage may be demonstrated only microscopically (microscopic Nikolsky’s sign and can increase the sensitivity of the histopathological studies. Methods: We studied 40 patients and divided them randomly into two groups (A, B). Group A were subjected to the tangential pressure over the perilesional skin before a biopsy specimen was taken from that site; group B patients were subjected to a biopsy without the tangential pressure technique. Results: Histopathological changes of pemphigus vulgaris were present in 30% of the patients in group A and 5% of the patients in group B. They were not statistically different. The presence of microscopic Nikolsky’s sign was significantly higher in patients with generalized disease. Conclusion: Microscopic Nikolsky sign can increase the sensitivity of histologic diagnosis of PV.
Shahshahani Mostafa Mirshams; Esmaily Nafiseh; Hallaji Zahra; Kamyab Kambiz; Kalaghchi Bita; Maghsoudnia Gholamreza; Kashani Mansour Nasiri; Narraghi Zahra; Razzaghi Mahmoud; Noormohammadpour Pedram
Volume 11, Issue 2 , 2008, , Pages 73-75
Abstract
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients ...
Read More
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients referred from general clinics with skin biopsies consistent with Basal Cell Carcinoma were enrolled. A questionnaire including epidemiologic data, risk factor exposure and specification of skin lesions was completed for each patient. Results: From October 2005 to October 2006, a total of 476 patients with cutaneous malignancy referred to Tumor clinic of Razi hospital. Of them, 367 patients had BCC. 215 were male (58%) and 152 were female (42%). Mean age of patients was 62 (±12.7) and 62 (±13.4) years for men and women, respectively. The most common risk factors for BCC were radiotherapy and chronic sun exposure. The most common tumor sites were scalp, nose and ears. Of different clinico-pathologic types, noduloulcerative type was the most common. Conclusion: It seems that radiotherapy is an important risk factor in Iranian BCC patients and it is useful to have a screening program for case finding and treating patients in early stages.
