Fariba Ghalamkarpour; Reza Robati; Ghadeh Ghasir; Mohammad Saeedi; Nahid Mohtasham
Volume 14, Issue 1 , 2011, , Pages 12-15
Abstract
Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. ...
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Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. Methods: Twenty eight patients in two groups were treated with 308nm excimer laser alone (14 patients) and the combination of excimer laser–calcipotriol (14 patients). After 16 sessions, response rate, side-effects and compliance were assessed. Results: Repigmentation rate more than 50% was significantly higher in the laser- calcipotriol group. No differences were seen in complication rate between the two groups. Conclusion: Combination of calcipotriol and 308nm excimer laser might enhance the response rate without increasing treatment complications.
Behrooz Barikbin; Afsaneh Maarefat; Rayhaneh Rahgoshai; Hamideh Moravvej; Nahid Mohtasham; Maryam Yousefi
Volume 13, Issue 4 , 2010, , Pages 131-134
Abstract
Background: Hand eczema is one of the most common dermatologic diseases requiring treatment but common therapeutics such as corticosteroids and anti-histamines have numerous side effects. So, use of herbal agents, which generally have no major side effects, may be useful especially if their efficacy ...
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Background: Hand eczema is one of the most common dermatologic diseases requiring treatment but common therapeutics such as corticosteroids and anti-histamines have numerous side effects. So, use of herbal agents, which generally have no major side effects, may be useful especially if their efficacy is established. Malva Sylvestris (MS) is a tropical plant in Iran with cooling characteristics. Hence, in this study, its efficacy in of the treatment of hand eczema was evaluated. Methods: In this randomized clinical trial, 50 patients with hand eczema who were visited at Shohada-e Tajrish and Loghman hospitals, Tehran, Iran, between 2006 and 2008, were recruited and divided into two groups. In the first group, MS 4% ointment was applied twice a day and in the other group, placebo ointment was usd. The efficacy and side effects were evaluated three and six weeks after beginning of the treatment. Results: Mean age of the patients was 37.3 years and 35.6 years in MS and placebo groups, respectively (P > 0.05). There were no therapeutic adverse effects in the groups. There was a statistically significant difference in all measured scores between two groups in the first and second follow-up sessions (P < 0.0001). Conclusion: Malva Sylvestris seems to be a safe and effective therapeutic modality for the treatment of hand eczema and can be used as an optimal substitute for corticosteroids and antihistamines.
Hamideh Moravvej; Maryam Yousefi; Nahid Mohtasham; Nelda Saadat; Hamid Reza Haghighatkhah
Volume 11, Issue 3 , 2008, , Pages 108-112
Abstract
Background: Few studies have investigated on vitamin D metabolites Serum levels, and calcium homeostasis in humans receiving retinoids, despite a substantial amount of literature concerning retinoid-induced osteoporosis in animals. We prospectively measured vitamin D metabolites serum levels and calcium ...
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Background: Few studies have investigated on vitamin D metabolites Serum levels, and calcium homeostasis in humans receiving retinoids, despite a substantial amount of literature concerning retinoid-induced osteoporosis in animals. We prospectively measured vitamin D metabolites serum levels and calcium homeostasis and radiographic bone changes in short course treatment with oral isotretinoin in severe acne.Methods: 1,25-dihydroxy vitamin D and 25-hydroxy vitamin D, calcium, phosphate, Parathyroid hormone and axial spine , femoral neck radiographies were measured in 30 nodulocystic acne patients ( 17 -28 years ) before and after twenty weeks of treatment with oral isotretinoin at the recommended dose (0.75 -1 mg/kg/day) .Results: vitamin D metabolites, calcium, phosphate, Parathyroid-hormone did not change significantly and hyperostosis and other sclerotic change were not observed in any patients.Conclusion: Short course treatment with oral isotretinoin at the recommended dose did not lead to any significant changes in serum vitamin D metabolites, calcium, phosphate and Parathyroid hormone and has no effects on bone radiography in acne patients.