Yalda Nahidi; Naser Tayyebi Meibodi; Pooran Layegh; Sara Sharifi
Abstract
Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar ...
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Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar study on an Iranian population, we decided to investigate and compare the serum lipid levels of LP patients and normal healthy subjects.Methods: In this case-control study, 71 patients with lichen planus confirmed by clinical and pathological examination who referred to dermatology clinic were recruited; further included were 71 subjects selected from attendants without any skin diseases matched for age, gender and BMI.with patients; the well-being of the healthy subjects was confirmed by laboratory tests, physical examination and medical history..After filling the questionnaire, triglyceride, cholesterol, HDL and LDL levels were measured for patients and healthy subjects..The collected data were then analyzed.Results: Mean age of patients in the case group was 40.63 ± 11.41 years, 50.6% of whom were men, while 49.4% were women. Cholesterol, triglyceride and LDL levels in patients were significantly higher than the control group; it was only regarding HDL levels that no significant difference was observed between the two groups. HDL and triglyceride levels were significantly higher in patients with generalized disease. There was a recognizable correlation between elevated levels of LDL and cholesterol and disease duration.Conclusions: In this study, a disrupted lipid profile was observed in LP patients, which can be associated with disease severity. This study proposes measuring lipid serum levels prior to commencing the treatment in all known cases of lichen planus so as to preclude cardiovascular diseases if there is a problem with the lipid profile.
Yalda Nahidi; Naser Tayyebi Meibodi; Habibollah Esmaili
Volume 17, Issue 3 , 2014, , Pages 81-84
Abstract
Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to ...
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Background: Vitiligo is a common cutaneous depigmentation disorder caused by the destruction of melanocytes. The exact etiopathogenesis of this disorder is not well known, but a complex of genetic, immunologic, inflammatory, and cytotoxic factors have been implicated. According to reports on the role of vitamin B12 and folic acid deficiency as important co-factors in the metabolism of homocysteine, we expected an increase in homocysteine levels in patients with vitiligo; therefore, our aim was to investigate the serum levels of homocysteine in Iranianpatients with vitiligo.Method: Forty patients with vitiligo and 40 healthy controls matched for age and sex were studied. After exclusion of cases with diseases that could affect the homocysteine level, serum homocysteine levels were measured by ELISA.Result: Males comprised 57.5% of the participants in both groups and 42.5% were female. The mean age of the patients was 24.68 ± 12.44 years. The level of homocysteine in the case andcontrol groups was 18.56 ± 5.69 and 10.19 ± 4.40, respectively, which was significantly higher in patients with vitiligo (P ? 0.001). There was no correlation between homocysteine levels and age,sex, history of previous treatment, duration of disease, and the extent of body surface involvement. Serum homocysteine levels in patients with regressive vitiligo (13.8) were lower thanprogressive (18.4) and stable (20.4) cases (P = 0.05).Conclusion: We found that the increase in serum homocysteine level in patients genetically susceptible to vitiligo could be a predisposing factor for the development of vitiligo. The serumhomocysteine level is associated with disease activity, and may be used as a prognostic factor for disease activity.
Pouran Layegh; Hamid Reza Arshadi; Sara Shahriari; Fakhrolzaman Pezeshkpour; Yalda Nahidi
Volume 13, Issue 4 , 2010, , Pages 106-111
Abstract
Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree ...
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Background: Due to their chronic nature, influences on the body image, hopelessness toward complete recovery and frequent recurrences, dermatological diseases seem to be one of the important predisposing factors in depression and suicidal ideation. Thus, the present study aimed at evaluating the degree of depression and suicidal ideation in patients with psoriasis, acne, alopecia areata and vitiligo.Methods: The study was carried out on 300 patients with psoriasis, acne, alopecia and vitiligo who were referred to the dermatology clinic of Ghaem Hospital in Mashad. Beck depression questionnaire was used to collect the data which was then statistically analyzed with ANOVA and T-test, using SPSS software.Results: In this study, 35.7% (107) of the subjects were female and 64.3% (193) were male with a mean age of 26.55±10.81 years. The prevalence rate of clinical depression was found to be 47.4% in patients with acne; 69.4% in those with psoriasis; 70.1% in those suffering from vitiligo; 50% in diffuse alopecia areata; 60% in universalis alopecia areata; 100% in ophiasis alopecia areata and 68.3% in patients with localized alopecia areata. As for suicidal ideation, there was no sign in 88.3% (265); however, 6.3% (19) of the patients reported to have thought of suicide but they had no desire for the attempt while 4% (12) of them had some desire for suicide and 1.3% (4) were seriously determined to commit suicide if only they would find themselves in an appropriate situation.Conclusion: As shown by the findings of the study, there was a close relationship between dermatological diseases and psychological factors; thus, it is important to immediately diagnose concurrent psychological effects, especially those of depression and suicidal ideation. We found that there was a significant relationship between the prevalence rate of dermatological conditions and psychological effects; i.e. depression (P=0.008) and suicidal ideation (P=0.001). We also found out that the rate of suicide attempt was highest among the patients with universalis alopecia, diffuse alopecia areata and vitiligo, respectively.