Firooz Alireza; Hallaji Zahra; Khatami Alireza; Lajevardi Vahideh; Mansouri Parvin; Pedram Mehryan; Zohreh Mozafari; Mansour Nassiri-Kashani; Reza Robati; Hassan Seirafi
Volume 18, Issue 3 , 2015, , Pages 81-96
Abstract
Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian ...
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Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.One of the missions of the Iranian Society of Dermatology is to develop strategies in order to provide the best possible management for patients suffering from dermatological conditions. To accomplish this mission, the Society assigned a committee to search and critically appraise the recent research evidence and available guidelines to develop a clinical practice guideline concerning diagnosis and treatment of urticaria.
Mahsa Ghajarzadeh; Hassan Seirafi; Hossein Alinia; Kamran Balighi; Hossein Mortazavi; Maryam Akhyani
Volume 14, Issue 4 , 2011, , Pages 129-130
Abstract
Vitiligo is an autoimmune skin disease which is characterized by depigmented patches due to loss of pigment cells. Evidence suggests that cell-mediated immunity plays a role in melanocyte destruction while some patients have antibodies to melanocytes or melanocytic proteins. Vitiligo is strongly associated ...
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Vitiligo is an autoimmune skin disease which is characterized by depigmented patches due to loss of pigment cells. Evidence suggests that cell-mediated immunity plays a role in melanocyte destruction while some patients have antibodies to melanocytes or melanocytic proteins. Vitiligo is strongly associated with a number of autoimmune disorders. Autoimmune thyroiditis is the most prevalent disease with a prevalence of 21%1. Diabetes mellitus type I is found in 1-7% of the patients with vitiligo 2 and pernicious anemia is reported in 5% of the vitiligo patients 3. The goal of this study was to determine the association of vitiligo with other autoimmune diseases (diabetes, thyroid dysfunction, pernicious anemia) in Iranian patients. From January 2009 until January 2010, one hundred vitiligo patients were randomly selected (through simple random selection) from the outpatient clinic of Razi Hospital.
Hassan Seirafi; Maryam Daneshpazhouh; Somayeh Khezri; Pardis Kiani; Sara Sabouri Rad; khadijeh Moghadam; Farzaneh Khezri
Volume 14, Issue 2 , 2011, , Pages 58-63
Abstract
Background: There is a large variety of therapeutic agents for the treatment of vitiligo, but it still remains a challenge. Narrow-band UVB phototherapy and 308-nm excimer laser have been shown to be safe and effective for the treatment of vitiligo. Topical calcipotriol has recently been reported to ...
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Background: There is a large variety of therapeutic agents for the treatment of vitiligo, but it still remains a challenge. Narrow-band UVB phototherapy and 308-nm excimer laser have been shown to be safe and effective for the treatment of vitiligo. Topical calcipotriol has recently been reported to enhance the efficacy of phototherapy, especially 8-methoxypsoralen plus UVA (PUVA). The goal of this study was to evaluate whether the addition of topical calcipotriol enhances the efficacy of 308-nm excimer laser in the treatment of vitiligo. Methods: The patients with symmetrical vitiliginous lesions received 308-nm excimer laser plus Calcipotriol ointment 0.005% (Daivonex®) as the intervention group and 308 nm excimer laser plus vaselin as the control group on the lesions of the right side. All patients in the two groups applied vaselin on the lesions of the left side. The evaluation of the patients was performed at baseline and at 12th week (the last laser session). SPSS version 15.0 package software was used for statistical analysis. P-values< 0.05 were accepted as statistically significant. Results: Seventy out of 83 patients completed the study. The diameter of the right side lesions (308nm excimer laser + calcipotriol) changed from 27.21 cm2 to 15.82 cm2 in the intervention group and from 27.86 cm2 to 16.02 cm2 in the control group; This difference was not statistically significant (p-value=0.74). Conclusion: Our findings showed that 308-nm excimer laser was effective and safe in the treatment of vitiligo, and that topical calcipotriol had no additive or synergistic effect.
