MJ Nazemi; AH Ehsani; M Ghiasi; R Mahmooud Robati; F Gouran
Volume 9, Issue 2 , 2006, , Pages 122-126
Abstract
Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study ...
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Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study the efficacy of oral erythromycin was compared with doxycyclin in the treatment of moderate to severe acne vulgaris.Materials and Methods: This study was planned and conducted as a double-blind clinical trial. Sixty eight patients with acne were divided into two groups. One group was treated with oral erythromycin with a dose of 1g/day and the other group received oral doxycyclin at a dose of 100 mg/day for 4 months. The clinical improvement was evaluated based on reduction in the number of lesions in each monthly visit. Adverse events were also recorded.Results: Both groups showed considerable improvement in the lesions of face and trunk wih no significant difference. There was also no significant difference between improvement in facial and truncal lesions in the patients treated with erythromycin but facial lesions significantly improved more than trucal ones in patients on doxycyclin.Conclusion: The efficacy of oral erythromycin and doxycyclin was not significantly different in the treatment of acne vulgaris and each of them can be used according to the clinical status of the patients.
H Seirafi; M Nakhjavani; F Farnaghi; AH Ehsani; P Hashemi; M Ghiasi; A Moosavi
Volume 9, Issue 2 , 2006, , Pages 150-153
Abstract
Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with ...
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Background and aim: Acne is a chronic inflammatory disease of the pilosebaceous units. Its etiology is unknown. However, several studies have shown that some endocrinologic factors are involved in acne pathogenesis. The aim of this study was to assess some endocrionlogic indices in male patients with acne vulgaris and comparing them with normal controls.Materials and Methods: In this case-control study, 40 male patients with acne referred to Razi hospital during the first 9 months of 1382, and 20 age-matched healthy subjects were selected. Plasma level of insulin, fasting blood sugar (FBS), free testosterone and sex hormone binding globulin (SHBG) were determined and compared between the groups.Results: The mean FBS level was 89.8±13.3 mg/dl in patients with acne and 91.1±16.3 in controls (P=0.017). The mean free testosterone level in cases and controls were 24.8±12.01 and 21.4±10.8 nmol/L, respectively (P=0.029).Conclusion: In this study, the testosterone level in patients with acne was higher and the FBS level was lower than controls. It is recommended that these indices be taken into consideration in male patients with acne.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
AH Ehsani; N Ghandi; Sh Yazdanian; F Farahani
Volume 9, Issue 2 , 2006, , Pages 185-188
Abstract
Becker's naevus is an acquired persistent asymmetrical area of skin pigmentation, sometimes showing evidence of increased androgen sensitivity, and colocalizing with other developmental anomalies. We report a 30-year-old woman with clinical findings compatible with Becker's naevus on her right breast ...
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Becker's naevus is an acquired persistent asymmetrical area of skin pigmentation, sometimes showing evidence of increased androgen sensitivity, and colocalizing with other developmental anomalies. We report a 30-year-old woman with clinical findings compatible with Becker's naevus on her right breast accompanied with hypoplasia of ipsilateral breast.
AH Ehsani; Sh Yazdanian
Volume 8, suppl , 2005, , Pages 10-13
Abstract
Epidermal nevi are cutaneous hamartomas developing from ectoderm and one of their types is verrucous epidermal nevus. During the neonatal period, they are pink or slightly pigmented and velvety. Later, they darken and the surface become more warty. When lesions are distributed on one side of body, it ...
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Epidermal nevi are cutaneous hamartomas developing from ectoderm and one of their types is verrucous epidermal nevus. During the neonatal period, they are pink or slightly pigmented and velvety. Later, they darken and the surface become more warty. When lesions are distributed on one side of body, it is termed nevus unis lateralis. Lymphangioma is a lymphatic malformation which manifests with fluid- filled vesicles bulged on the skin surface.We present a 30- year – old man with pigmented, hyperkeratotic plaques on right side of his body associated with clear vesicles predominant at right side of his natal cleft. The histopathologic report of above lesions were epidermal nevus and lymphangioma, respectively.
AH Ehsani; M Ghiasi; F Gorouhi; RM Robati
Volume 8, suppl , 2005, , Pages 29-33
Abstract
Lipoid proteinosis, a rare autosomal recessive disorder, presents in early childhood with hoarseness, skin infiltration and thickening, beaded papules on eyelid margins, and facial acneiform or pock- like scars. Although
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Lipoid proteinosis, a rare autosomal recessive disorder, presents in early childhood with hoarseness, skin infiltration and thickening, beaded papules on eyelid margins, and facial acneiform or pock- like scars. Although
M Mir Shams Shahshahani; AH Ehsani; RM Robati
Volume 8, suppl , 2005, , Pages 42-14
Abstract
Pulsed dye laser (PDL) is an effective treatment for port- wine stain and can cause some short- term and long- term side- effects. Pyogenic granoluma is one of its late- onset adverse effects. Herein, we present two cases of pyogenic granoluma following treatment of port- wine stain with PDL.
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Pulsed dye laser (PDL) is an effective treatment for port- wine stain and can cause some short- term and long- term side- effects. Pyogenic granoluma is one of its late- onset adverse effects. Herein, we present two cases of pyogenic granoluma following treatment of port- wine stain with PDL.
MS Hosseini; AH Ehsani; S Toosi; R Mahmoud Robati
Volume 8, Issue 5 , 2005, , Pages 394-407
M Mir Shams Shahshahani; AH Ehsani; S Toosi
Volume 8, suppl , 2005, , Pages 49-52
Abstract
Port- wine stain is a congenital vascular malformation originating from superficial dermal vessels which is characterized by ectasia of the capillaries. Currently, pulsed dye laser (PDL) is used to treat these vascular lesions. To date, there are few reports of eczematous lesions due to PDL. Herein, ...
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Port- wine stain is a congenital vascular malformation originating from superficial dermal vessels which is characterized by ectasia of the capillaries. Currently, pulsed dye laser (PDL) is used to treat these vascular lesions. To date, there are few reports of eczematous lesions due to PDL. Herein, we report three cases of eczema following PDL, used for treatment of port- wine stain in Razi hospital. Dermatitis following laser therapy is not frequent but may be seen occasionally. Therefore, Patients should be informed on the possibility of this adverse effect before instituting the treatment.
AH Ehsani; M Ghiasi; M Asgari
Volume 8, suppl , 2005, , Pages 60-64
Abstract
Eruptive vellus hair cysts are disorders that present as cystic papules usually on the chest and extremities. Facial involvement is very rare in this disorder and few reports of facial eruptive vellus hair cysts have been presented till now.We present two cases of eruptive vellus hair cysts in a mother ...
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Eruptive vellus hair cysts are disorders that present as cystic papules usually on the chest and extremities. Facial involvement is very rare in this disorder and few reports of facial eruptive vellus hair cysts have been presented till now.We present two cases of eruptive vellus hair cysts in a mother and her daughter with facial distribution.
M Akhyani; Z Hallaji; AH Ehsani; T Mokarrami; F Gorouhi
Volume 8, Issue 3 , 2005, , Pages 171-176
Abstract
Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol ...
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Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol and oral methoxalene plus PUVA in treatment of generalized Vitiligo. Patients and Methods: In this clinical trial, 47 patients with generalized Vitiligo (<40% involvement of skin surface area) were randomly assigned to 2 treatment groups. Both groups were treated with systemic PUVA three times weekly. One group was also treated with topical Calcipotriol (0.005%). Patients were evaluated for treatment response and possible side effects. Results: The mean response rate at the end of the study was 63.9%±24.1 in the Calcipotriol and PUVA group and 60.6%±23 in the PUVA group (P>0.05). The number of PUVA sessions and the mean cumulative UVA dose for maximum response were 96.6±22.7 and 584.1±118.1 J/cm² in the Calcipotriol and PUVA group and 116.3±26.1 and 685.1±168.0 J.cm² in the PUVA group (P<0.05). Conclusion: In patients with generalized Vitiligo, combination of PUVA with Calcipotriol is an effective and safe treatment. This method decreases number of PUVA sessions and UVA dosage compared to PUVA treatment alone and accelerates repigmentation.
S Kavusi; AH Ehsani; S Toosi; A Naser Tork
Volume 8, Issue 2 , 2005, , Pages 145-148
Abstract
Mal de meleda (Keratoderma plamoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma with hyperkeratosis of palms and soles, which appears soon after birth and progressively involves other areas (Transgrediens) of the skin especially dorsal aspects of hands and feet. ...
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Mal de meleda (Keratoderma plamoplantaris transgrediens) is a rare autosomal recessive form of palmoplantar keratoderma with hyperkeratosis of palms and soles, which appears soon after birth and progressively involves other areas (Transgrediens) of the skin especially dorsal aspects of hands and feet. We report a 20-year-old woman with mal de meleda with some unusual clinical features, i.e. peculiar finger nail anomalies and pseudoainhum on all her fingers.
AH Ehsani; Z Safaei Naraghi; R Mahmoud Robati; S Toosi
Volume 8, suppl , 2004, , Pages 35-38
Abstract
Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratotic acantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider ...
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Patients with keratotic lesions distributed in a unilateral, linear, zosteriform or localized pattern and revealing histopathologic features of dyskeratotic acantholysis have been reported previously. There is some controversy in the appropriate nosologic classification of this entity. Some authors consider it as a localized form of Darier’s disease while others place it as a variant of epidermal nevus. We report a 19-year-old girl who presented with 14 years history of an asymptomatic, hyperkeratotic area of skin-colored papules in a dermatomal distribution on the dorsum of her left hand and forearm. Pathological evaluation showed acantholysis and dyskeratosis. The controversy regarding the correct classification of such a patient is discussed.
MJ Nazemi Tabrizi; AH Ehsani; Y Sedaghat; P Noormohammad Pour; M Mohajer; P Saheb Nazar
Volume 8, Issue 1 , 2004, , Pages 15-18
Abstract
Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris ...
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Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris in patients with positive smear for P.ovale. Patients and Methods: A smear was obtained from lesions of 84 patients with acne vulgaris referred to Razi Hospital, Tehran. After determination of clinical and mycological grading, patients with positive smear for P.ovale were randomly treated with topical 2% ketoconazole cream or placebo. After 4 weeks the patients were evaluated for the clinical and mycological grading and treated with traditional anti-acne drugs. Results: Fifty-six of 84 patients had positive smears, 29 of them were treated with ketoconazole cream and 27 patients received placebo. Clinical grading before treatment was 2.60 and 2.21 in ketoconazole and placebo groups, which was reduced to 2.16 and 2.05, respectively. Mycological grading reduced from 1.4 to 0.44 in ketoconazole group, but did not change in placebo group (1.42). Conclusion: 2% ketoconazole cream was more effective than placebo in reduction of mycological grading but did not have any effect on clinical grading of acne.
M Mirshams Shahshahani; S Alami Harandi; AH Ehsani
Volume 8, Issue 1 , 2004, , Pages 39-43
Abstract
Background: Urticaria is a common skin disease characterized by transient and itchy swelling. The spectrum of etiologic factors in urticaria is very wide and contains external factors such as drugs, foods and internal diseases such as infections, SLE, hormonal factors and even lymphoma. Objective: To ...
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Background: Urticaria is a common skin disease characterized by transient and itchy swelling. The spectrum of etiologic factors in urticaria is very wide and contains external factors such as drugs, foods and internal diseases such as infections, SLE, hormonal factors and even lymphoma. Objective: To determine different kinds of urticaria and different etiologic and prevocational factors in patients with urticaria. Patients and Methods: This descriptive study was carried on 120 patients with urticaria referred to Razi Hospital in Tehran in year 1376. They were evaluated in two groups: Acute and chronic urticaria, duration of 6 weeks was the limit between them. Results: About 30% of patients had acute urticaria and causes were determined in 58% of them. Upper respiratory tract infections, drugs and foods were the most common etiologic factors. In only 22% of patients with chronic urticaria, the causes were found, which included infections (Sinusitis, hepatitis B, intestinal parasitic infections), drugs (NSAIDs and Codeine) and food. Fifty percent of these patients had common urticaria, 22% of them were affected with one of the physical urticarias and in 22% of them a combination of two or more kinds of urticaria were founded. Conclusion: The most important factor in determining the cause and provocation of urticaria are taking detailed history and performing thorough clinical examination. Paraclinical studies had a little role in determining etiology of urticaria.
MJ Nazemi Tabrizi; AH Ehsani; SN Emadi; P Noormohammad Poor; P Mehrian
Volume 8, Issue 1 , 2004, , Pages 62-65
Abstract
Although lichen planus is a fairly common disorder, its familial occurrence is uncommon and varies between 1.5 and 10.7%. In most reports, only two or three members of the family have had disease but occasionally more family members may be affected. We present a case of lichen planus, whose father, mother, ...
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Although lichen planus is a fairly common disorder, its familial occurrence is uncommon and varies between 1.5 and 10.7%. In most reports, only two or three members of the family have had disease but occasionally more family members may be affected. We present a case of lichen planus, whose father, mother, and maternal aunt also had this disease.
M Akhyani; H Mortazavi; M Izadi; AH Ehsani
Volume 7, Issue 1 , 2003, , Pages 14-18
Abstract
Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin ...
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Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin in the treatment of patients with pityriasis rosea. Patients and Methods: In this double-blind randomized clinical trial, 46 patients with pityriasis rosea in two equal groups were treated with oral erythromycin 1gr per day or placebo for seven days and were followed 1, 2 and 6 weeks after treatment. The response to the treatment was evaluated as complete, partial and no response. Results: In 48% of the case group and 13% of the control group complete response was seen at the end of first week of treatment. Moreover, these rates reached 91% and 57% at the end of second week, 100% and 87% at the end of sixth week, respectively. The differences between two groups were statistically significant after first and second weeks. Conclusion: Oral erythromycin was effective in the treatment of patients with pityriasis rosea. Also, it reduces the duration of disease.
MJ Nazemi; S Arad; H Haji Hosseini; AH Ehsani
Volume 6, Issue 4 , 2003, , Pages 24-27
Abstract
Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients ...
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Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients and Methods: In this open clinical trial without control group, 30 patients with acne referred to Razi Hospital in Tehran (Mean age 18) years were treated with 70% glycolic acid and their clinical improvement was evaluated. Results: Mean numbers of comedones were 24.4±15.2 and 2.6±5.9 in first and last visits respectively (P<0.005). Moreover, 18 patients (60%) and 12 patients (40%) had complete and relative improvement, respectively. The side effects of this treatment were minimum and transient. Conclusion: Superficial peeling with 70% glycolic acid is effective in treatment of mild acne.
M Mirshams Shahshahani; M Fathabadi; AH Ehsani; M Zakeri
Volume 5, Issue 3 , 2002, , Pages 35-40
Abstract
Background: Eccrine hydrocystomas are essentially eccrine sweat gland retention cyst located in the dermis that clinically presents as small translucent cystic swelling. Objective: This study was designed to evaluate the efficacy and safety of 20% aluminum chloride hexahydrate in absolute alcohol in ...
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Background: Eccrine hydrocystomas are essentially eccrine sweat gland retention cyst located in the dermis that clinically presents as small translucent cystic swelling. Objective: This study was designed to evaluate the efficacy and safety of 20% aluminum chloride hexahydrate in absolute alcohol in the treatment of eccrine hydrocystoma. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 33 patients with multiple eccrine hydrocystoma referred to Tehran Razi hospital during the summer of 2000, were divided in two groups: One group received 20% aluminum chloride hexahydrate in absolute alcohol and the other one received only absolute alcohol. The patients applied the drugs to dried skin at bedtime, and washed the area in the morning. Results: Excellent or good therapeutic effects (More than 50% of improvement) were achieved in 87.5% of patients who applied 20% aluminum chloride hexahydrate but only in 17.6% of patients in control group (P<0.0001). The mean age in the first group was 42.6 years and in placebo group 45.4 years. Side effects in the first group included pruritus, burning (37.5%), xerosis and scaly (31.2%) and erythema (25%), in control group the rate of these side effects were 23.5%, 17.6%, and 11.7% consequently. Conclusion: 20% aluminum chloride hexahydrate solution is an effective and safe topical agent in the treatment of multiple eccrine hydrocystomas.
M Akhyani; AH Ehsani; B Barikbin
Volume 5, Issue 2 , 2002, , Pages 43-46
Abstract
Syringoma is a benign tumor arising from intra-epidermal ducts of eccrine sweat glands. It usually presents as small translucent papules on eyelids and upper cheeks. The case, which is presented, is a rare from of syringoma that occurred in a linear fashion on the trunk. Dermatologists should be aware ...
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Syringoma is a benign tumor arising from intra-epidermal ducts of eccrine sweat glands. It usually presents as small translucent papules on eyelids and upper cheeks. The case, which is presented, is a rare from of syringoma that occurred in a linear fashion on the trunk. Dermatologists should be aware of such form of syringoma to differentiate it from other similar lesions. This 23 year-old man with one year history of flesh-colored to red papules on the left side of this chest, with a distribution following Blashko lines, without any pruritus or burning sensation, presented to the skin clinic of Razi hospital in 1380. On histopathologic examination of the lesions, islands and epithelial strands with differentiation to eccrine gland ducts were observed. Also some duct-like structures similar to tad pole and comma-shaped structures were seen in the dermis, all of which were consistent with the diagnosis of syringoma.
H Mortazavi; AH Ehsani; Z Safaei Naraghi; M Asgari
Volume 4, Issue 4 , 2001, , Pages 34-40
Abstract
We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. ...
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We report of a 29-year-old man presented with yellow-red, scaling papules on the skin of scalp, retro-auricular folds, inguinal, axillary, chest and abdomen. The lesions had a poikilodermatious appearance in some areas, such as trunk. The patient also had diabetes insipidus and skull osteolytic lesions. The diagnosis of langerhans cell histiocytosis (LCH) was suggested based on H and E staining of skin biopsy specimen. S-100 staining was positive in immunohistochemistry. Birbeck granules were seen in electron microscopic examination confirming the diagnosis of LCH. Considering the systemic involvement, he is a case of an extensive LCH in new classification and a case of Hand-Schuller-Christian in the old classification. The cutaneous lesions of the patients responded to oral thalidomide 200 mg daily after 2 months and did not recur after 6 months follow up.