Z Nilforooshan; A Asilian; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 11-16
Abstract
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon ...
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Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon but well recognized phenomenon, and since almost all of them were developed on exposed areas it has been hypothesized that the accompanying atrophy and decreased vascularity and adnexal structures in areas of scarring may render the affected tissues more susceptible to the effects of environmental factors, eg. ultraviolet light. We report four cases of BCC and SCC on old leishmania scars on face, and recommend that any changes on scars must be evaluated clinically and pathologically.
A Asilian; Z Nilforooshan
Volume 5, Issue 2 , 2002, , Pages 3-10
Abstract
Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin ...
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Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin disorders was compared to placebo. Patients and Methods: In a controlled clinical trial, 40 patients (21 patients with post-herpetic neuralgia, 10 with lichen simplex chronicus, and 9 with notalgia paresthetica), with the mean age of 48 years were randomly treated with 0.075% capsaicin gel or placebo q.i.d. for 4 weeks. The severity of symptoms and side effects were assessed every two weeks and recurrence was assessed also two months after treatment. Results: 31 cases (77%) completed their 4 weeks treatment period. According to visual Analogue Score system, the mean of symptom severity decreased from 7.6 (±2.4) before treatment to 0.9 (±0.9) after treatment in capsaicin group and decreased from 6.3 (±2.3) to 5.0 (±3.2) in placebo group (P<0.05). Conclusion: Capsaicin gel is effective in painful and pruritic skin disorders and has tolerable side effects.
