M Akhyani; M Danesh Pazhooh; M Barzegari; N Ghandi; M Ghiasi; Z Chenari; S Soudavari
Volume 9, Issue 3 , 2006, , Pages 242-249
Abstract
Background and aim: Hirsutism is a common clinical problem among women; however estimates regarding its prevalence in our population are limited. The objective of this study was to estimate the frequency and features of hirsutism in yound women in Iran.Materials and Methods: This descriptive-cross sectional ...
Read More
Background and aim: Hirsutism is a common clinical problem among women; however estimates regarding its prevalence in our population are limited. The objective of this study was to estimate the frequency and features of hirsutism in yound women in Iran.Materials and Methods: This descriptive-cross sectional study was performed on 800 female (18-25 years) medical students of Tehran medical universities in 1999. Evaluation included a history and a modified Ferriman-Gallwey hirsutism score in four different androgen-sensitive skin areas. The volunteers recorded their weight and height, the presence of menstural dysfuncion, acne, positive family history for hirsutism, as well as ingestion of oral contraceptive pills, corticosteroids or anabolic steroids using a questionnaire. Data were analyzed using chi-square test and P<0.05 was considered significant.Results: The frequency of hirsutism in our population was 22.8% (183 of 800). 17.3%, 5.1% and 0.3% of the population studied had mild, moderate and severe hirsutism, respectively. The prevalence of obesity (body mass index > 25), acne, positive family history for hirsutism, menstrual dysfunction, and consumption of corticosteroid and OCP was significantly higher in hirsutes.Conclusion: Hirsutism is a very common abnormality in this group of woman in Iran. Higher hirsutism frequency in this survey comparing to previous records in other population shows that the hirsutism definition and scoring system should be modified due to racial/ethnic variations in terminal hair quantity and distributions and different concept of this abnormality in each population.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
Read More
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
M Vali Khani; H Ghani Nejad; M Barzegari; Z Hallaji; S Toosi
Volume 8, suppl , 2005, , Pages 18-23
Abstract
This is a report of a 40- year- old woman presented to our outpatient dermatology clinic. She had a 40- day history of sudden development of skin lesions on the exposed. Dermatologic examination revealed relatively limited brown – reddish plaques on the hands, feet, face, one elbow and groin regions. ...
Read More
This is a report of a 40- year- old woman presented to our outpatient dermatology clinic. She had a 40- day history of sudden development of skin lesions on the exposed. Dermatologic examination revealed relatively limited brown – reddish plaques on the hands, feet, face, one elbow and groin regions. She has been taking carbamazepine (200 mg/ day) for 13 years. Otherwise, no serious problems were found. A clinical diagnosis of drug- induced pellagra was made based on the morphology. After discontinuing carbamazepine, treatment with nicotinamide (500 mg/day) was initiated and the eruption faded away and resolved within 3 weeks. Pellagra is a disease caused by a deficiency of the niacin and may occur with certain drugs.
M Barzegari; SN Emadi; RM Robati
Volume 8, Issue 3 , 2005, , Pages 237-241
Abstract
Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ...
Read More
Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ago. Diffuse pigmentation of his skin took our attention. According to the patient, diffuse hyperpigmentation was present at birth and there was no obvious changes up to now. His mother and sister had similar hyperpigmentation. He had 2 sons with a similar hyperpigmentation, but his daughter had normal skin pigmentation. All laboratory investigation for the causes of hyperpigmentation were reported normal and investigation for causes of secondary hyperpigmentation did not reveal any abnormality. In histopathological assay, the erythematous lesion was reported to be discoid lupus erythematous and the diagnosis of hyperpigmented lesion reported as congenital diffuse Melanosis.
N Esmaeili; M Barzegari; M Rezaei
Volume 8, Issue 2 , 2005, , Pages 110-114
Abstract
Background: Lichen planus (LP) is an idiopathic papulosquamous disorder, which can show cutaneous or mucosal signs. It is caused by a cell mediated immune response to an antigen. A wide range of clinical manifestations has been reported. Objective: To determine the sex and age frequency and clinical ...
Read More
Background: Lichen planus (LP) is an idiopathic papulosquamous disorder, which can show cutaneous or mucosal signs. It is caused by a cell mediated immune response to an antigen. A wide range of clinical manifestations has been reported. Objective: To determine the sex and age frequency and clinical presentations of this disease in patients referred to Razi hospital in Tehran. Patients and Methods: In this observational case series study, patients referred to Razi hospital in Tehran from May to July 2003 were examined and clinically or clinicopathologically confirmed cases of LP were selected. Results: One-hundred and twenty patients had LP (52 females-68 males). The age range was 6-80 years and the mean age was 40.6 years. Sixty-seven of patients had cutaneous lesions, 20% had mucocutaneous and 13% had mucosal lesions. Hypertrophic LP was present in 22% and typical or classic LP was seen in 18%. Seven percent of patients had scalp involvement and oral LP was present in 33.3% of cases and the most common form was reticular. Genital lesions were present in 6% of cases mainly in male cases and as annular form. Six percent of patients had positive family history of LP. Conclusion: In this study LP was more common in male patients and in fourth decade of life. Hypertrophic LP and classic LP were the most common and reticular form was the most common form of oral LP. Genital lesions were mainly seen in male patients and as annular form.
M Barzegari; H Ghaninejad; M Shizarpoor
Volume 7, Issue 4 , 2004, , Pages 237-241
Abstract
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. ...
Read More
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. Patients and Methods: 40 patients with generalized plaque type psoriasis with PASI scores of 15-20 in Razi Hospital in Tehran were randomly divided into 2 groups after giving consent. Each group included 20 patients. The first group was treated three times a week with bath-PUVA and the second group was treated with acitretin 0.7 mg/kg/day. The efficacy of 2 treatment regimens were determined and compared using PASI scores. Results: The clearance rate was 65% in bath-PUVA group and 75% in acitretin group. Patients in bath-PUVA needed 29 sessions and accumulative dose of 105.46 J/cm² for clearance. Conclusion: Psoriasis patients responded to bath-PUVA treatment but this response required more sessions and higher total dose. The inherent differences and distinctive responses to light in the patients under study (In Iran) compared with patients with skin phototypes I, II might explain these differences.
M Barzegari; Sh Shams Davachi; A Kianfar
Volume 7, Issue 4 , 2004, , Pages 261-263
Abstract
Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was ...
Read More
Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was to compare the serum prolactin levels and the frequency of hyperprolactinemia in autoimmune skin patients with a control group. Patients and Methods: Serum prolactin levels were measured in 44 patients with autoimmune blistering skin diseases and 44 age and sex matched normal persons. Results: The mean serum prolactin level was higher in the patients group than the control group (13.7 ng/ml vs. 8.4 ng/ml). Seven of 44 patients (16%) had hyperprolactinemia, which was significantly higher than control group (P=0.006). Conclusion: According to this study a higher frequency of hyperprolactinemia was observed in patients suffering from autoimmune blistering diseases in comparison with a control group.
M Valikhani; M Barzegari; F Aghainia
Volume 5, Issue 2 , 2002, , Pages 11-14
Abstract
Background: Localized and extensive clinical subtypes of alopecia areata (AA) including alopecia totalis and alopecia universalis differ in genetic and immunologic aspects. Objective: Comparison of epidemiologic aspects of localized and extensive subtypes of AA. Patients and Methods: In a prospective ...
Read More
Background: Localized and extensive clinical subtypes of alopecia areata (AA) including alopecia totalis and alopecia universalis differ in genetic and immunologic aspects. Objective: Comparison of epidemiologic aspects of localized and extensive subtypes of AA. Patients and Methods: In a prospective descriptive study, 180 patients suffering from AA attending the skin clinics of Razi Hospital in Tehran in 6-month period were studied. The epidemiological aspects of the disease including age at onset, duration, family history, and mental stress were compared in the localized and extensive subtypes of AA. Results: The age at onset was 13.2 years in localized and 19.3 years in extensive AA (P<0.05). The duration of disease was remarkably longer in the extensive form (42.5 months vs. 17.5 months in localized AA). The role of mental stress was mentioned in 55.6% of cases with extensive form and 27.8% of cases with localized AA (P<0.05). There was no relation between family history of AA and the clinical subtype of disease. Conclusion: Extensive AA begins at a younger age, has longer course, and stronger relation with stress.