MJ Nazemi; AH Ehsani; M Ghiasi; R Mahmooud Robati; F Gouran
Volume 9, Issue 2 , 2006, , Pages 122-126
Abstract
Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study ...
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Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study the efficacy of oral erythromycin was compared with doxycyclin in the treatment of moderate to severe acne vulgaris.Materials and Methods: This study was planned and conducted as a double-blind clinical trial. Sixty eight patients with acne were divided into two groups. One group was treated with oral erythromycin with a dose of 1g/day and the other group received oral doxycyclin at a dose of 100 mg/day for 4 months. The clinical improvement was evaluated based on reduction in the number of lesions in each monthly visit. Adverse events were also recorded.Results: Both groups showed considerable improvement in the lesions of face and trunk wih no significant difference. There was also no significant difference between improvement in facial and truncal lesions in the patients treated with erythromycin but facial lesions significantly improved more than trucal ones in patients on doxycyclin.Conclusion: The efficacy of oral erythromycin and doxycyclin was not significantly different in the treatment of acne vulgaris and each of them can be used according to the clinical status of the patients.
MJ Nazemi; SN Emadi; S Toosi
Volume 8, suppl , 2004, , Pages 5-10
Abstract
Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients ...
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Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients receiving cyclosporin. We report herein a 57-year-old woman who developed multiple warts on her hands and feet, lower lid syringomas, sebaceous gland hyperplasia of forehead and multiple mucosal irritation fibromas on tongue after kidney transplantation and a long course of treatment with oral cyclosporin, azathioprine and prednisolone since 6 years ago.
MJ Nazemi; S Arad; H Haji Hosseini; AH Ehsani
Volume 6, Issue 4 , 2003, , Pages 24-27
Abstract
Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients ...
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Background: Comedone formation has an essential role in pathophysiology of acne, therefore destroying of comedones and preventing of comedone formation is very important in acne treatment. Objective: To determine the effect of superficial peeling with 70% glycolic acid in the improvement of acne. Patients and Methods: In this open clinical trial without control group, 30 patients with acne referred to Razi Hospital in Tehran (Mean age 18) years were treated with 70% glycolic acid and their clinical improvement was evaluated. Results: Mean numbers of comedones were 24.4±15.2 and 2.6±5.9 in first and last visits respectively (P<0.005). Moreover, 18 patients (60%) and 12 patients (40%) had complete and relative improvement, respectively. The side effects of this treatment were minimum and transient. Conclusion: Superficial peeling with 70% glycolic acid is effective in treatment of mild acne.
MJ Nazemi; S Sotoodeh; H Moslehi
Volume 6, Issue 2 , 2003, , Pages 5-13
Abstract
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The ...
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Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referred to Razi Hospital in Tehran in 1377 were recorded in special questionnaires. Data were analyzed by SPSS software, T-Student and chi-square tests were used. Results: The number of female patients was twice of males, majority in the age range of 20 to 50 years, Most of the patients had no complaints except for skin eruptions. Paraclinical abnormalities were rare. The paraclinical changes were various, but hydropic degeneration of basal layer was found in all cases. Conclusion: Complementary studies are suggested to evaluate similarities and differences in Iranian and non-Iranian patients with DLE.
H Mortazavi; MJ Nazemi; N Zarinpour
Volume 6, Issue 2 , 2003, , Pages 53-57
Abstract
Bloom syndrome is a rare autosomal recessive genetic disorder, which is characterized by telangiectasia and erythema in the butterfly area of the face, dwarfism and photosensitivity. The case presented herein is a 22-year-old man who referred with facial erythema and telangiectasia (Resembling lupus ...
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Bloom syndrome is a rare autosomal recessive genetic disorder, which is characterized by telangiectasia and erythema in the butterfly area of the face, dwarfism and photosensitivity. The case presented herein is a 22-year-old man who referred with facial erythema and telangiectasia (Resembling lupus erythematosus). The skin lesions were exacerbating during summer. Other clinical findings were proportionally short stature and bird-like facies, spots on the trunk. Chromosomal study was done which showed chromosome instabilities including gaps breaks, fragment and rearrangements in 90% of metaphases studies. Regarding to clinical findings and results of the chromosomal study, diagnosis of Bloom syndrome was established.