M Akhyani; M Danesh Pazhooh; M Barzegari; N Ghandi; M Ghiasi; Z Chenari; S Soudavari
Volume 9, Issue 3 , 2006, , Pages 242-249
Abstract
Background and aim: Hirsutism is a common clinical problem among women; however estimates regarding its prevalence in our population are limited. The objective of this study was to estimate the frequency and features of hirsutism in yound women in Iran.Materials and Methods: This descriptive-cross sectional ...
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Background and aim: Hirsutism is a common clinical problem among women; however estimates regarding its prevalence in our population are limited. The objective of this study was to estimate the frequency and features of hirsutism in yound women in Iran.Materials and Methods: This descriptive-cross sectional study was performed on 800 female (18-25 years) medical students of Tehran medical universities in 1999. Evaluation included a history and a modified Ferriman-Gallwey hirsutism score in four different androgen-sensitive skin areas. The volunteers recorded their weight and height, the presence of menstural dysfuncion, acne, positive family history for hirsutism, as well as ingestion of oral contraceptive pills, corticosteroids or anabolic steroids using a questionnaire. Data were analyzed using chi-square test and P<0.05 was considered significant.Results: The frequency of hirsutism in our population was 22.8% (183 of 800). 17.3%, 5.1% and 0.3% of the population studied had mild, moderate and severe hirsutism, respectively. The prevalence of obesity (body mass index > 25), acne, positive family history for hirsutism, menstrual dysfunction, and consumption of corticosteroid and OCP was significantly higher in hirsutes.Conclusion: Hirsutism is a very common abnormality in this group of woman in Iran. Higher hirsutism frequency in this survey comparing to previous records in other population shows that the hirsutism definition and scoring system should be modified due to racial/ethnic variations in terminal hair quantity and distributions and different concept of this abnormality in each population.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
M Akhyani; Z Hallaji; AH Ehsani; T Mokarrami; F Gorouhi
Volume 8, Issue 3 , 2005, , Pages 171-176
Abstract
Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol ...
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Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol and oral methoxalene plus PUVA in treatment of generalized Vitiligo. Patients and Methods: In this clinical trial, 47 patients with generalized Vitiligo (<40% involvement of skin surface area) were randomly assigned to 2 treatment groups. Both groups were treated with systemic PUVA three times weekly. One group was also treated with topical Calcipotriol (0.005%). Patients were evaluated for treatment response and possible side effects. Results: The mean response rate at the end of the study was 63.9%±24.1 in the Calcipotriol and PUVA group and 60.6%±23 in the PUVA group (P>0.05). The number of PUVA sessions and the mean cumulative UVA dose for maximum response were 96.6±22.7 and 584.1±118.1 J/cm² in the Calcipotriol and PUVA group and 116.3±26.1 and 685.1±168.0 J.cm² in the PUVA group (P<0.05). Conclusion: In patients with generalized Vitiligo, combination of PUVA with Calcipotriol is an effective and safe treatment. This method decreases number of PUVA sessions and UVA dosage compared to PUVA treatment alone and accelerates repigmentation.
M Akhyani; H Mortazavi; M Izadi; AH Ehsani
Volume 7, Issue 1 , 2003, , Pages 14-18
Abstract
Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin ...
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Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin in the treatment of patients with pityriasis rosea. Patients and Methods: In this double-blind randomized clinical trial, 46 patients with pityriasis rosea in two equal groups were treated with oral erythromycin 1gr per day or placebo for seven days and were followed 1, 2 and 6 weeks after treatment. The response to the treatment was evaluated as complete, partial and no response. Results: In 48% of the case group and 13% of the control group complete response was seen at the end of first week of treatment. Moreover, these rates reached 91% and 57% at the end of second week, 100% and 87% at the end of sixth week, respectively. The differences between two groups were statistically significant after first and second weeks. Conclusion: Oral erythromycin was effective in the treatment of patients with pityriasis rosea. Also, it reduces the duration of disease.
AR Keshtkar Jafari; M Akhyani; A Akhavan Malayeri; V Kheiri
Volume 7, Issue 1 , 2003, , Pages 33-37
Abstract
Background: Alopecia areata is a patchy hair loss that may occur in any hair bearing area on the body. There are many reports of ocular abnormalities such as lens and retinal changes in alopecia areata. Objective: To evaluate ocular alterations in alopecia areata with regard to the lens and retina. Patients ...
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Background: Alopecia areata is a patchy hair loss that may occur in any hair bearing area on the body. There are many reports of ocular abnormalities such as lens and retinal changes in alopecia areata. Objective: To evaluate ocular alterations in alopecia areata with regard to the lens and retina. Patients & Methods: Seventy three patients with alopecia areata including 34 males and 39 females, 69.6% partialis, 11% totalis and 19.2% universalis, were examined with slit lamp, fundoscopy and indirect ophthalmoscopy after full dilatation of pupils. Results: There was not any changes in patients’ lens and retina in this study. Conclusion: This study showed that lens and retinal changes are uncommon in alopecia areata.
M Akhyani; AH Ehsani; B Barikbin
Volume 5, Issue 2 , 2002, , Pages 43-46
Abstract
Syringoma is a benign tumor arising from intra-epidermal ducts of eccrine sweat glands. It usually presents as small translucent papules on eyelids and upper cheeks. The case, which is presented, is a rare from of syringoma that occurred in a linear fashion on the trunk. Dermatologists should be aware ...
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Syringoma is a benign tumor arising from intra-epidermal ducts of eccrine sweat glands. It usually presents as small translucent papules on eyelids and upper cheeks. The case, which is presented, is a rare from of syringoma that occurred in a linear fashion on the trunk. Dermatologists should be aware of such form of syringoma to differentiate it from other similar lesions. This 23 year-old man with one year history of flesh-colored to red papules on the left side of this chest, with a distribution following Blashko lines, without any pruritus or burning sensation, presented to the skin clinic of Razi hospital in 1380. On histopathologic examination of the lesions, islands and epithelial strands with differentiation to eccrine gland ducts were observed. Also some duct-like structures similar to tad pole and comma-shaped structures were seen in the dermis, all of which were consistent with the diagnosis of syringoma.