Mohammad Ali Mapar; Simin Mansorian; Nader Pazyar; Mohammadreza Keshavarz; Atefeh Mansorian
Abstract
Background: Warts are among the most common skin diseases with various recommended treatments, including topical ablation, chemotherapy, and immunotherapy. However, given the unsatisfactory response rate, complications, and recurrence, effective treatment remains controversial. This study compared formalin ...
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Background: Warts are among the most common skin diseases with various recommended treatments, including topical ablation, chemotherapy, and immunotherapy. However, given the unsatisfactory response rate, complications, and recurrence, effective treatment remains controversial. This study compared formalin against an anti-wart compound containing salicylic acid and lactic acid.Methods: This clinical trial recruited 58 patients with wart lesions on hands and feet randomly divided into two groups of daily topical treatment: formalin 5% (n = 29) and anti-wart lotion containing salicylic acid 16.7% and lactic acid 16.7% in flexible collodion (n = 29) for eight weeks. Patient satisfaction and recovery were assessed and compared between the groups at weeks four and eight.Results: Patient satisfaction did not change significantly in either group (P > 0.05), and no significant difference was observed between the groups (P = 0.838). The number of wart lesions fell significantly after eight weeks in both groups (P < 0.001), with no significant difference between them (P = 0.225). There was no significant difference between the two methods in terms of side effects (P = 0.084).Conclusion: Both formalin and salicylic acid plus lactic acid lotion effectively treated plantar and common warts, and neither had any significant side effects. The treatment choice should be based on the patient’s age, the number of lesions, and the site affected.
Reza Yaghoobi; Nader Pazyar; Hooman Kalantar; Azita Nikoo; Zahra Naraghi; Kambiz Kamyab; Alireza Ganadan; Zohre Khodashenas; Azadeh Goodarzi; Fatemeh Mohaghegh
Volume 20, Issue 1 , 2017, , Pages 21-25
Abstract
Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification ...
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Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification of BCCs based on interobserver diagnostic judgment. Methods: We conducted this cross-sectional study on 100 randomly selected pathologically confirmed BCC cases of various subtypes at Razi Hospital, Tehran, Iran during 2013 and 2014. A total of four dermatopathologists independently reviewed each pathology slide to evaluate the interobserver concordance rate. Results: The overall Fleiss’ kappa statistic (kappa) for the BCC subtypes was 0.18 (P<0.001), which indicated slight agreement. We observed moderate agreement on superficial and nodular BCC (kappa: 0.0-0.4); fair agreement on infiltrative and keratotic BCC (kappa: 0.2-0.4); and slight agreement on pigmented, micronodular, and metatypical BCC (kappa: 0.0-0.2). There was moderate agreement diagnosis for the low and high risk growth pattern categories. Conclusion: Overall, we found that the dermatopathologists had inconsistent nomenclature for the BCC subtypes, however they had better agreement for the diagnosis of superficial, nodular, and infiltrative subtypes and the high risk growth pattern.
