Emadodin Darchini-Maragheh; Sara Fakhraei; Pouran Layegh
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant hereditary syndrome caused by mutations of the MEN1 tumor suppressor gene. We describe a patient with a prior confirmed diagnosis of pemphigus vulgaris (PV), who presented with new cutaneous manifestations that led to the diagnosis ...
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Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant hereditary syndrome caused by mutations of the MEN1 tumor suppressor gene. We describe a patient with a prior confirmed diagnosis of pemphigus vulgaris (PV), who presented with new cutaneous manifestations that led to the diagnosis of MEN1. A man in his early forties with a history of PV from 11 years ago presented with some cutaneous lesions six months ago, diagnosed as angiofibroma and collagenoma. Moreover, he suffered from recurrent renal stones and gout for several years. Laboratory analysis showed hypercalcemia, which led us to confirm the diagnosis of a parathyroid adenoma by sestamibi scintigraphy. Contrast-enhanced computed tomography (CT) of the abdomen revealed hyper-enhancing pancreatic lesions while the patient had no related symptoms. Thus, the clinical diagnosis of MEN1 syndrome was settled, and the patient underwent surgical and medical management. A hitherto unreported cooccurrence between MEN-1, as a hereditary syndrome, and PV, as an autoimmune bullous cutaneous dermatosis, opens a hazy challenging issue: whether MEN-1 has any association with autoimmune bullous cutaneous diseases like PV or increases the incidence of such conditions.
Akram Momenzadeh; Mahboubeh Khajavi; Mohammad Reza Kazemi; Mehrdad Teimoorian; Fatemeh Livani; Masoud Saleh Moghadam; Pouran Layegh
Abstract
Background: Pemphigus vulgaris (PV) is an autoimmune disease with worldwide distribution. Human leukocyte antigen G (HLA-G) is postulated to be associated with this inflammatory and autoimmune condition. However, its role has not been well established in the literature. The study aimed to evaluate the ...
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Background: Pemphigus vulgaris (PV) is an autoimmune disease with worldwide distribution. Human leukocyte antigen G (HLA-G) is postulated to be associated with this inflammatory and autoimmune condition. However, its role has not been well established in the literature. The study aimed to evaluate the plasma level of HLA-G in PV patients and assess its correlation with disease severity and compare it with normal subjects.Methods: Thirty PV patients were enrolled in this cross-sectional study. A blood sample was taken from each participant; samples were analyzed for the soluble HLA-G (sHLA-G) plasma level by applying an ELISA kit (sHLA-G ELISA kit; Exbio, Czech Republic). Patients’ clinical and demographic data were recorded and analyzed.Results: Higher levels of sHLA-G were seen in PV patients compared to the control group (P < 0.05). There was a negative linear relationship between plasma HLA-G level and PV based on all ABSIS indices except for oral involvement (-1 < R < 0); however, these correlations were not statistically significant (P≥0.05).Conclusion: Our data showed higher plasma sHLA-G levels in PV patients, which did not correlate with disease severity.
Yalda Nahidi; Elahe Abdali; Masoud Maleki; Azadeh Saki; Pouran Layegh
Abstract
Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated ...
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Background: Striae is a common condition that is relatively difficult to treat. Recently, carboxytherapy was proposed as a treatment modality. This study aimed to evaluate the therapeutic effect of carboxytherapy in patients with striae.
Methods: This was a pilot clinical study. Patients were treated with 10 sessions of carboxytherapy every week. The patients were photographed at the onset of the treatment course, before each treatment session, and three months after the last ones. Two dermatologists compared the images of each patient before and three months after treatment and evaluated the treatment response based on the following scores: I, no improvement (0%);II, poor (1% to 25%); III, fair (26% to 50%); IV, good (51% to 75%); and V, excellent improvement (76% to 100%). Furthermore, patients’ satisfaction with therapy outcome was recorded on a scale of 0 to 10.
Results: 15 patients were enrolled in this study; 2 (13.4%) were male and 13 (86.6%) were female. Three patients (20%) showed good response, one (6.7%) had a relatively good response, two showed (13.3%) poor response, and seven (46.6%) had no response to treatment. Analysis of the association of carboxytherapy outcomewith different patients’ characteristics showed no statistically significant correlation (P > 0.05).
Conclusions: Although carboxytherapy therapy did not result in a significant response in the majority of our patients, it is somehow capable of improving the striae in some patients. Further studies with bigger sample sizes may be required to ensure the efficacy of this modality in the treatment of striae.
Yalda Nahidi; Vahid Mashayekhi Goyonlo; Pouran Layegh; Hoda Marhamati; Mona Najaf Najafi
Abstract
Background: Zinc is an effective factor in the immune response against infectious agents; its effect on the course of cutaneous leishmaniasis (CL) is unknown. This study aimed to compare the serum zinc level in patients with acute and chronic CL. Methods: A descriptive study was conducted on 120 CL cases ...
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Background: Zinc is an effective factor in the immune response against infectious agents; its effect on the course of cutaneous leishmaniasis (CL) is unknown. This study aimed to compare the serum zinc level in patients with acute and chronic CL. Methods: A descriptive study was conducted on 120 CL cases and controls. This included 30 cases of acute CL (less than one year of lesion recovery), 30 cases of chronic CL (period of illness over one year), and 60 healthy subjects with age and gender proportional to the patients. Volunteers entered the study with knowledge and consent. The serum zinc level was measured by atomic absorption spectrophotometry. Results: The percentages of people with reduced serum zinc levels in the healthy, acute, and chronic groups were 13.3, 50, and 43.3%, respectively, whereby there was a significant difference between the leishmaniasis groups (acute and chronic) and the control group (p <0.001). However, the mean serum zinc level did not differ significantly between the acute (75.36 ± 15.72 µg/dl) and chronic (73.96 ± 17.98 µg/dl) leishmaniasis groups (P=0.94). Conclusions: A reduced serum zinc level is associated with symptomatic CL, but does not affect the clinical outcome and recovery.
Sara Sabouri Rad; Masoumeh Hosseini-Nejad; Naser Tayyebi Meibodi; Pouran Layegh
Volume 19, Issue 1 , 2016, , Pages 29-31