Atieh Ebadi; Farhad Malekzad; Mohmmadreza Khorramizadeh; Ariana Kariminejad; Fahimeh Shahabipour; Reza M Robati
Abstract
Cutis laxa (CL) is a connective tissue disease thatis either inherited or acquired. It is characterized by redundant,pendulous, and inelastic skin. Loss of elasticity is a pathologicalfeature of some degenerative and inflammatory diseases. Matrixmetalloproteinases (MMPs) can cleave elastin fibers by ...
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Cutis laxa (CL) is a connective tissue disease thatis either inherited or acquired. It is characterized by redundant,pendulous, and inelastic skin. Loss of elasticity is a pathologicalfeature of some degenerative and inflammatory diseases. Matrixmetalloproteinases (MMPs) can cleave elastin fibers by damagingthe microfibrils and the elastin core, resulting in the loss ofelasticity.In this study, we report eight patientswith different types of cutis laxa along with the quantitativemeasurement of serum levels of MMP-2 and MMP-9.The cutis laxa patients showed various clinical andhistopathological findings, indicating the heterogeneity of thisrare skin connective tissue disease. The serum level of MMP-2and MMP-9 were elevated in these patients.Increased MMP-2 and MMP-9 might be associatedwith cutis laxa. However, our findings need to be validated inlarger clinical settings.
Farhad Malekzad; Reza Robati; Hamidreza Abaei; Somayeh Hejazi; Azin Ayatollahi; Shima Younespour
Volume 14, Issue 4 , 2011, , Pages 136-139
Abstract
Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, ...
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Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance.Methods: This single-centre, case- control study was performed between 2008 and 2010 to evaluate the metabolic state of thirty chronic plaque type psoriatic patients in comparison with the control group. The criteria of insulin resistance (Body Mass Index (BMI), Systolic Blood Pressure, Fasting Plasma Glucose, Oral Glucose Tolerance Test (OGTT), Serum Insulin and Lipid Profile) were assessed for each participant.Results: Thirty psoriatic patients with a mean disease duration of 3.94 + 2.96 years and 30 healthy controls were recruited for the study. Only one patient in each group filled the criteria of insulin resistance, and there was no significant difference between the two groups. The mean Fasting Plasma Glucose (FPG), Triglyceride (TG) and Systolic Blood Pressure (SBP) levels were significantly higher in psoriasis patients as compared to the controls (p=0.044, p=0.014 and p=0.001, respectively). In contrast, no statistically significant differences were observed in mean BMI, OGTT, insulin and HDL levels between the two groups.Conclusion: Despite the absence of any significant association between insulin resistance and psoriasis, it could be concluded that psoriasis may be an independent risk factor for diseases such as Ischemic Heart Disease (IHD) and Diabetes Mellitus (DM), hypertension and obesity.
Soheila Nassiri; Farhad Malekzad; Mojdeh Sarlak; Marjan Saeedi; Mehdi Hedayati; Mehdi Qaisari
Volume 12, Issue 2 , 2009, , Pages 56-59
Abstract
Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched ...
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Background: The etiology of psoriasis, a chronic inflammatory skin disease, has not been elucidated. However, Oxidant / antioxidant imbalance is suspected.The aim of this study was to evaluate oxidant / antioxidant status in psoriatic patients.Method: forty two psoriatic patients and 42 age and sex matched controls were recruited for this study. Serum total antioxidant capacity (TAC), oxidized light density lipoprotein (Ox-LDL) and malondialdehyde (MDA) levels were determined.Results: A statistically significant increase in the serum level of MDA was found between patients and controls. No significant difference was found in the serum levels of other parameters in the two groups.Conclusion: Our results supported the hypothesis of an imbalance between oxidants and antioxidants in psoriasis and pointed to the probability of an increased risk of cardiovascular diseases in psoriatic patients.
Farhad Malekzad; Behrooz Barikbin; Zahra Ghoorchiani
Volume 10, Issue 1 , 2007, , Pages 78-82
Abstract
Perforating granuloma annulare (PGA) is a rare subtype of GA. It is characterized by crops of erythematous umblicated or scaly papules. Plaques, pustule-like lesions and scars may also be seen. It can be localized or generalized.Transepithelial elimination of mucinous, degenerating collagen fibers and ...
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Perforating granuloma annulare (PGA) is a rare subtype of GA. It is characterized by crops of erythematous umblicated or scaly papules. Plaques, pustule-like lesions and scars may also be seen. It can be localized or generalized.Transepithelial elimination of mucinous, degenerating collagen fibers and surrounding palisading lymphohistiocytic granulomas, are important histologic features.The patient reported here was a 23-year-old man with recurrent crops (every few weeks) of umbilicated papular lesions predominantly affecting trunk and extremities for 8 years, which resolved with varioliform scars.