Jahangir Majid; Qayoom Seema; Peerzada Sajad; Naseer Choh; Rifat Ara; Kafeel Khan
Volume 18, Issue 1 , 2015, , Pages 1-5
Abstract
Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting ...
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Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting as hirsutism, for ultrasonographic evidence ofpolycystic ovaries (PCO), in addition to recording their clinical andhormonal profile. The purpose of this study was to determine theprevalence of polycystic ovary syndrome using ultrasonography,in young Kashmiri women presenting as hirsutism.Method: In total, one hundred and seventy (170) consecutive youngKashmiri women presenting with chief complaint of hirsutismwere assessed. A total of eighty (80) age matched non- hirsutefemales having normal menstrual cycles, served as controls. Theovaries were visualised by transabdominal ultrasonography (USG).The serum was analysed for luteinizing hormone (LH), folliclestimulating hormone (FSH), total testosterone (tT), prolactin(PRL) and thyroid stimulating hormone (TSH).Result: The study showed prevalence of 61.18% PCOS in youngKashmiri women presenting as hirsutism. PCOS was diagnosed in35.11% hirsute women with regular menses and ultrasonographywas used to identify PCO in 90.35% patients. Biochemicalhyperandrogenemia was present in 70.15% of the patients andthe LH/FSH ratio increased in 81.73% of the patients.Conclusion: The results of this study show a high prevalence ofPCOS in young Kashmiri women presenting as hirsutism andalso highlights the fact that PCOS is not necessarily associatedwith menstrual disturbances. Therefore, all hirsute women, evenwith regular menses, should be evaluated for PCOS.
Hussain Sajjad; Hassan Iffat; Majeed Sabiya; Showkat A Bhat; Hinah Altaf; Peerzada Sajad
Volume 17, Issue 4 , 2014, , Pages 117-121
Abstract
Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system ...
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Background: Psoriasis is a chronic inflammatory disease of theskin. The etiology of psoriasis is not known exactly. Recently, ithas been suggested that an imbalance in the oxidant- antioxidantstatus due to an increased reactive oxygen species production and/or deficient function of the antioxidant system may be involvedin the pathogenesis of psoriasis. The aim of this study was toevaluate the antioxidant defense status in patients with psoriasisand to look for a correlation, if any, between the antioxidantdefense status and the severity of psoriasis.Method: Sixty patients with psoriasis and an equal number ofage and sex matched healthy controls were enrolled in the study.Plasma levels of malondialdehyde (MDA), reduced glutathione(GSH), and superoxide dismutase (SOD), and antioxidant potential(AOP) were measured in cases as well as controls.Result: Patients with psoriasis were found to have significantlyhigher levels of plasma SOD (P < 0.001) and MDA (P < 0.001)and lower levels of GSH (P < 0.001) than controls. Plasma AOPwas not significantly different between patients and controls(P= 0.822).Conclusion: The results of our study support the hypothesisof an imbalance in the oxidant –antioxidant status in psoriasis,which could contribute to the pathogenesis of psoriasis.
Iffat Hassan; Peerzada Sajad; Syed Mubashir
Volume 17, Issue 3 , 2014, , Pages 101-103
Abstract
Background: Bowen’s disease is a form of intraepidermal squamous cell carcinoma (SCC) characterised by a persistent, non-elevated, red, scaly or crusted plaque with a small potentialfor invasive malignancy. Most cases of typical Bowen’s disease in the white population are found ...
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Background: Bowen’s disease is a form of intraepidermal squamous cell carcinoma (SCC) characterised by a persistent, non-elevated, red, scaly or crusted plaque with a small potentialfor invasive malignancy. Most cases of typical Bowen’s disease in the white population are found on the lower legs of the elderly women. However, in this part of the world, i.e. Kashmir, the mostcommon site is thighs followed by the lower abdomen. A range of treatment options are available for it including cryotherapy, curettage and cautery, photodynamic therapy, laser destruction,surgical excision, 5-fluorouracil cream, imiquimod cream, and radiotherapy. The aim of this study was to evaluate the efficacy of surgical excision in Bowen’s disease.Method: All the patients with biopsy proven Bowen’s disease were included for the study. A detailedhistory was taken for each patient including the history of medical treatment for Bowen’s disease. Wide surgical excision (including either fusiform excision, W-plasty, or Z-plasty) was performed in each patient and the patients were then followed up for any recurrence. No sign of renewed disease activity at 6 months follow-up was taken as cure. All patients are intended to be followed up for 5 years.Result: Ten out of 12 patients reported the use of topical imiquimod cream but complained of the progression of lesions. Surgical excision was performed in 12 patients. All the patients are currently under regular follow-up. Except for secondary infection and wound dehiscence in one patient, all the patients are in good condition with no signs of recurrence.Conclusion: Although it was a preliminary study, we recommend surgical excision in treatment of Bowen’s disease due to low recurrence rate.