Hosseini Mahboobeh-Sadat; Ehsani Amir Hooshang; Hosseinpanah Farhad; Azizi Fereydoon; Salami Maryam; Khedmat Hossein
Volume 11, Issue 3 , 2008, , Pages 113-117
Abstract
Bachground: Skin lesions are common in type 2 diabetic patients and its association with microvascular complications been reported. Methods: In this study, 1135 type-2 diabetic patients were included and examined by a dermatologist for diabetes mellitus related skin lesions, skin infections and cutaneous ...
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Bachground: Skin lesions are common in type 2 diabetic patients and its association with microvascular complications been reported. Methods: In this study, 1135 type-2 diabetic patients were included and examined by a dermatologist for diabetes mellitus related skin lesions, skin infections and cutaneous complications of the treatment. Smear, culture and biopsy of the lesions were done for definite diagnosis. Weight, height, blood pressure were also done. FBS and HbA1C were measured for all patients Results: The mean age of the study population was 54±11 years; 619 were (55%) female and 516 were (45%) male. Mean duration of the disease was 9±7 years and HbA1c was 7.8±1.6. The prevalence of skin lesions was 64% (95%CI: 61.2-66.8). The most common solitary skin lesion was diabetic dermopathy (32.3%) while the most common condition observed overall was skin infections (41.5%). Acanthosis nigricans with a prevalence of 26.4% was the third most common lesion. Other skin conditions had a prevalence of less than 12%. Skin disorders were apparently more prevalent in male than in female patients.Conclusion: More than sixty percent of patients with type-2 diabetes mellitus have skin lesions.
Leila Nabai; Mohammad Ebrahimzadeh Ardakani; Mohammad Shahidi Dadras; Soheila Nasiri
Volume 10, Issue 1 , 2007, , Pages 32-36
Abstract
Background and aim: Diabetes mellitus is a metabolic disease with multiple complications. Skin tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients ...
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Background and aim: Diabetes mellitus is a metabolic disease with multiple complications. Skin tag is a pedunculated papule, which is more common in women and has been suggested as a cutaneous marker of diabetes mellitus. The aim of this study was to determine the frequency of diabetes mellitus in patients with skin tags.Materials and methods: This descriptive study was done on 100 patients with skin tags. The investigation included fasting blood sugar (FBS) and glucose tolerance test (GTT).Results: 66 patients had normal FBS, 27 had diabetes mellitus, 5 had impaired GTT and 2 had impaired fasting glucose. Over all, 34 had abnormal glucose metabolism, 7 were unaware of their metabolic abnormality. Among 40 hospitalized patients 50% had abnormal glucose metabolism meanwhile 23.3% of 60 outpatients had this abnormality (p<0.01). No association was seen between BMI, obesity, gender, location and number of skin tags with abnormal metabolism of glucose.Conclusion: It is recommended to consider skin tags as a cutaceous marker for abnormality of glucose metabolism.
ZB Mousavi; A Vaezi
Volume 9, Issue 1 , 2006, , Pages 86-88
G Sadeghian; MA Nilfroush Zadeh; M Amini
Volume 8, Issue 6 , 2006, , Pages 466-470
Abstract
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of ...
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Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.Materials and Methods: Glucose tolerance test (GTT) and fasting blood insulin were measured in two groups of obese women (BMI>30 kg/m2) with AN (32 cases) and without AN (34 cases) and insulin resistance was determined using HOMA formula.Results: The mean fasting blood insulin in two groups with and without AN were 15.5±8.5 and 12.2±4.1 IU/mL; respectively (P<0.05). The mean of insulin resistance in two groups with and without AN were 3.5±1.9 and 2.6±0.9; respectively (P<0.05). The results of GTT showed that the mean fasting blood sugar was 89.5±12 mg/dl and following using glucose were 144±7 mg/dl after 30 minutes, 132±45 mg/dl after 60 minutes, 107±30 mg/dl after 120 minutes in persons with AN and in the other group were 87±8, 130±3, 122±26 and 100±26 mg/dl; respectively. The difference between two groups was only significant after 60 minutes.Conclusion: Acanthosis nigricans maybe a marker of insulin resistance in obese women.
MS Hosseini; AH Ehsani; S Toosi; R Mahmoud Robati
Volume 8, Issue 5 , 2005, , Pages 394-407
I Esfandiar Pour; F Darvish Damavandi; F Fahimi
Volume 7, Issue 3 , 2004, , Pages 185-191
Abstract
Generalized granuloma (GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is flesh colored, annular, grouped papules. They usually are on the extremities especially on the lateral ...
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Generalized granuloma (GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is flesh colored, annular, grouped papules. They usually are on the extremities especially on the lateral or dorsal surfaces of the fingers, hands, wrists, ankles, and insteps. Several clinical manifestations have been reported for this disease. Variants, such as localized, generalized, subcutaneous, linear, perforating and patch GA, have been reported. The generalized form may present as either disseminated, individual, usually skin-colored papules arise anywhere on the skin surface especially trunk, or annular to circinate erythematous lesions that resemble erythema multiform, erythema migrans, erythema annulare centrifugum and erythema gyratum repens. In latter group, the popular quality is less obvious than the erythema. In these lesions, rings may spread centrifugally and central hyper pigmentation may be present. This report describes a case of generalized GA in a 46-year-old diabetic woman with annular and circinate erythematous plaques resembling erythema annulare. At first according to clinical and histological findings, diagnosis of erythema gyratum repens had been suggested but later, GA was confirmed.
محمدهادی پورمقیم; حمیده صداقتی; حبیب انصارین; علی دیانت; سعادت مولانایی
Volume 6, Issue 4 , 2003, , Pages 46-50
Abstract
We report a diabetic patient who developed skin lesions on her left forearm and ulnar nerve involvement following admission to the hospital and putting IV catheter for her treatment. Biopsy samples wee taken from her skin lesions and ulnar nerve and with further evaluation after 2 months, the diagnosis ...
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We report a diabetic patient who developed skin lesions on her left forearm and ulnar nerve involvement following admission to the hospital and putting IV catheter for her treatment. Biopsy samples wee taken from her skin lesions and ulnar nerve and with further evaluation after 2 months, the diagnosis of fungal infection due to zygomycetes and mucur was considered based on the presence of non-septal hyphas with spreading to adjacent blood vessels. In specific staining, the sample was positive for fungal elements but its culture was negative. Clinical healing was observed after treatment with IV Amphotericin B. In general, in every diabetic or immunosupressed patient, even normal individuals with unusual infections without any response to common antibiotics, the possibility zygomycosis should be considered and histopathologic and fungologic evaluation should be done.