Alireza Ghanadan; Kambiz Kamyab; Ali Nili; Hamidreza Mahmoudi; Vahidehsadat Azhari; Anahita Borzouei; Shirin Taraz Jamshidi
Abstract
Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic ...
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Background: Pilomatricoma is a benign skin adnexal neoplasm. Various histological features are observed on microscopic examination. We aimed to evaluate this tumor’s demographic and histological features in detail.Methods: One hundred cases with a diagnosis of pilomatricoma were selected, and demographic and clinical data were entered into a checklist. The pathology slides were reviewed to confirm the diagnosis. The demographic profile of all patients, including age and gender, primary clinical impression, multiplicity of the tumor, microscopic features, and location of tumoral involvement, were extracted. Qualitative data were summarized using frequencies and percentages. Regarding descriptive analysis, the frequency of each histopathologic feature was calculated.Results: Two groups of patients were identified regarding age. This tumor was more common in males among adult patients, while a female preponderance was seen in those under 18. Most lesions were located on the face (40%), followed by upper (32%) and lower (10%) limbs. In addition to well-known histological features, we observed intraepidermal pilomatricoma in two cases presenting unique histopathologic features. Both showed foci of suprabasal cleft formation, while one showed the Borst-Jadassohn phenomenon. These features, in addition to sebaceous differentiation and acantholysis of ghost cells, were not addressed in previous literature.Conclusion: Understanding the diverse and new histological features of pilomatricoma is necessary for differentiating it from other adnexal and soft tissue tumors.
Nasiri Soheila; Hejazi Somayeh; Safoura Shakoei; Zahra Asadi; Nazi Saljoughi
Abstract
Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated ...
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Granuloma faciale (GF) is a benign disease that presents as solitary or multiple asymptomatic plaques on the face. We report a 25-year-old male patient with asymptomatic papular, pustular, and nodular lesions on both cheeks. Diagnosis of GF was made based on the histopathological findings. He was treated with cryotherapy and intralesional triamcinolone injections every month. After 3 months, the lesions became paler and less indurated.
Zabolinejad Naghmeh; Hoseininejad Masoumeh; Jannatipour Maryam; Layegh Pouran
Volume 20, Issue 4 , 2017, , Pages 122-126
Abstract
Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the ...
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Background: Hair loss is a major cause of dermatology visits resulting in considerable anxiety and distress for patients. The objective of the current research was to investigate the association among various diagnostic methods related to non-scarring hair loss in women. Methods: After obtaining the complete history, clinical examination was carried out on women suffering from diffuse nonscaring alopecia. Laboratory tests and histo-pathologic study were conducted for each patient, and ultimately, data were analyzed by SPSS version 16. Result: Forty-one women were enrolled with the average age of 28.1±8.4 years (16-48). Mean duration of hair loss was 6.2 years (2 months-20 years). The most prevalent type of hair loss was androgenetic alopecia. The sensitivity and specificity with which the clinical examination was done to detect this common ilk of hair loss was 94% and 25%, respectively. No acceptable correlation existed between laboratory test results (such as testosterone, DHEAS, ferritin and TSH) and clinical diagnosis. Data were further assessed through the use of IBM SPSS software version 22 using fisher exact test and Kappa coefficient. The significance level was set at p<0.05. Conclusion: Clinical examination is an accurate approach to diagnosing certain types of non-scarring hair loss in women, eliminating the necessity to perform various endocrinology and laboratory tests; however, it is only through histopathologic studies that an exact diagnosis is specified.
Anchal Jindal; Rushikesh Shah; Neela Patel
Volume 17, Issue 3 , 2014, , Pages 96-100
Abstract
Background: Immunobullous diseases are morphologically heterogeneous and the differentiation between various subtypes is essential for proper treatment and prognosis. The aim of our study was to analyze and correlate clinical, histopathological, and immunofluorescence findings in ...
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Background: Immunobullous diseases are morphologically heterogeneous and the differentiation between various subtypes is essential for proper treatment and prognosis. The aim of our study was to analyze and correlate clinical, histopathological, and immunofluorescence findings in autoimmune bullous diseases.Method: A cross-sectional study was conducted over a period of two years (2010-2012) after receiving the ethics committee approval. Sixty patients who met the inclusion criteria of immunobullous disease were included in the study. Skin biopsy for histopathological and direct immunofluorescence (DIF) examination was taken. DIF was also done in a few of the cases using the salt-split technique. The final diagnosis was based on clinical, histopathological, and DIFfindings.Result: Sixty cases with a clinical diagnosis of autoimmune bullous diseases were evaluated. In 95% of the cases, the histopathological diagnosis was consistent with the clinical diagnosis and in 75% of the cases, the DIF diagnosis was consistent with the clinical diagnosis. A positive relationship was seen between clinical and DIF findings with r = 0.67 and between histopathologic and DIF findings with r = 0.76. DIF positivity was seen in 100% of the cases of bullous pemphigoid (BP), 100% of the cases of pemphigus foliaceus, and 94.7% of the cases of pemphigus vulgaris which was statistically significant with P < 0.05.Conclusion: Our study provides evidence-based guidance for the diagnosis and classification of various immunobullous disorders. DIF test should be done in conjunction with histopathology tomake a definite diagnosis and minimize both false-positive and false-negative results.
A Zamanian; M Pilehvar
Volume 5, Issue 2 , 2002, , Pages 28-32
Abstract
Background: Pilomatricoma, the most common hair follicle tumor, has a wide variety of clinicopathological characteristics and is often misdiagnosed. Objective: The aim of this study was to explain the clinical and histological spectrum of tumor in order to help for its better diagnosis. Patients and ...
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Background: Pilomatricoma, the most common hair follicle tumor, has a wide variety of clinicopathological characteristics and is often misdiagnosed. Objective: The aim of this study was to explain the clinical and histological spectrum of tumor in order to help for its better diagnosis. Patients and Methods: In a retrospective descriptive study, the clinical and histological features of pilomatricoma were reviewed. The files and histologic sections of all biopsy specimens examined in Hamadan Sina Hospital between 1992 and 1999 were analyzed. Results: Among 4000 biopsy specimens, 22 cases of pilomatricoma were found. 59.3% of the lesions were located on upper extremities. The lesion developed in second decade of life in 36.5 percent of the patients. Shadow cells, calcifications, ossification and granulomatous reaction were detected in 100, 50, 9 and 45.5 percent of specimens, respectively. The accuracy of clinical diagnosis compared with pathologic findings was 36.5 percent. Conclusion: Pilomatricoma was the final diagnosis in 0.55 percent of all biopsy specimens examined in Hamadan Sina Hospital between the years 1992 to 1999. It should be included in differential diagnosis of skin tumors.
F Iraji; A Kiani; Sh Shahidi; R Vahabi
Volume 4, Issue 4 , 2001, , Pages 29-33
Abstract
Background: Warts are common in renal allograft recipients (RAR) with reported incidence of 24% to 100%. These patients also demonstrate an accelerated malignant transformation of warts. Although in immunocompetent patients, the histology of common warts is quite predictable, this is not so in RAR. Objective: ...
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Background: Warts are common in renal allograft recipients (RAR) with reported incidence of 24% to 100%. These patients also demonstrate an accelerated malignant transformation of warts. Although in immunocompetent patients, the histology of common warts is quite predictable, this is not so in RAR. Objective: The purpose of this study was to evaluate the histopathologic findings of warty lesions in RAR. Patients and Methods: We examined 55 RARs for warty lesions. We took biopsy specimens from lesions that clinically appeared to be common warts and evaluated their histopathologic features. Results: Among 55 RARs, 17 cases (30.9%) had warty lesions, and among 50 biopsied lesions, 47 lesions (94%) showed changes of verruca vulgaris and only 3 Lesions (6%) showed warts with dysplasia. No malignant transformation was reported. All patients were under treatment with prednisolone, cyclosporin and azathioprine. The median time passed from transplantation was 49 months. Conclusion: We couldn’t find evidence of dysplasia or malignancy in most verrucous lesions of RAR. This maybe due to relatively short time passed from transplantation in our patients.