Fariba Abbasi; Yousef Roosta; Rahim Asghari; Amin Mesgari
Abstract
Background: Survival studies are needed in patients with cutaneous malignant melanoma (CMM) due to the growing incidence trend worldwide. We aimed to determine the survival trend in patients suffering from CMM, considering various demographic and tumor characteristics.Methods: In this descriptive-analytical ...
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Background: Survival studies are needed in patients with cutaneous malignant melanoma (CMM) due to the growing incidence trend worldwide. We aimed to determine the survival trend in patients suffering from CMM, considering various demographic and tumor characteristics.Methods: In this descriptive-analytical study, we examined 57 patients with confirmed melanoma from April 2014 to February 2019. Using the Kaplan-Meier method and log-rank test, we assessed the correlation between survival probability and factors with prognostic potential, such as gender, age, tumor thickness, mitotic rate, anatomical sites, and chemotherapy.Results: Out of 57 patients with a mean age of 59.5 ± 22.7 years, 33 (57.9%) were females. The mean survival was 43 ± 15 months, ranging from 15 to 82 months. Regarding tumor thickness, 26 patients had 1–4 mm tumor thickness, 18 patients 5–10 mm, and five patients 11–30 mm. The tumor mitotic rate was 1–2 mitoses/ mm2 in 19 patients and ≥ 3 mitoses/mm2 in 32 patients. Infiltrated lymphocytes were present in 36 patients (36.6%). In the case of therapeutic intervention, 55 patients received chemotherapy. According to the results of the Kaplan-Meyer test, the mean survival did not show a significant difference (P < 0.05) in patient subgroups. Moreover, a profound correlation was not found between survival rate and different age groups, mitotic rate, thickness, lymphocyte infiltration, and chemotherapy.Conclusion: Irrespective of disease stage and histopathology examination, we found no significant correlation between survival rate and demographic/tumor characteristics in patients with CMM.
Yuichi Kurihara; Keiko Sakamoto-Tanegashima; Mitsuru Kinjo; Takeshi Nakahara; Masutaka Furue
Abstract
Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old ...
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Dermoscopy helps detect melanoma on the acral volar skin. A parallel ridge pattern is one of the characteristic dermoscopic findings of melanoma but is also seen in benign lesions, including drug-induced hyperpigmentation. Histological examination is therefore necessary for definitive diagnosis. A 74-year-old Japanese man was referred to our department with irregular-shaped brown macules on his palms and soles. The pigmented lesions had a parallel ridge pattern on dermoscopic examination. The largest lesion was resected at the patient’s insistence and considering the possibility of melanoma. Histopathological examination revealed increased melanin granules in basal keratinocytes and many melanophages in the superficial dermis, especially underlying the crista profunda intermedia, agreeing with the dermoscopic findings. The patient had been receiving tegafurgimeracil- oteracil (TS-1) for advanced gastric cancer. The pigmented lesions gradually regressed after cessation of TS-1, consistent with TS-1-induced hyperpigmentation. Further studies are needed to elucidate the pathogenesis, including analyses of the relationship between acrosyringeal endothelin-1 expression and the presence of volar melanocytes in relation to potential drug metabolism.
Hossain Kawosi; Nader Salari; Arash Golpazir Sorkhe; Ibrahim Shakiba; Roya Safarpour; Masoud Mohammadi
Abstract
Background: Malignant melanoma is a prevalent, offensive, andfatal cancer in developed countries. Most of our information isrelated to studies conducted in western countries. This studyaims to evaluate demographic and clinical data of melanoma inthe Kermanshah province of Iran.Method: This was a descriptive ...
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Background: Malignant melanoma is a prevalent, offensive, andfatal cancer in developed countries. Most of our information isrelated to studies conducted in western countries. This studyaims to evaluate demographic and clinical data of melanoma inthe Kermanshah province of Iran.Method: This was a descriptive study on data available in theCancer Registry Center of Kermanshah, which includes 70patients during eight years from 2010–2017. Clinical recognitionof melanoma was based on American Joint Committee on Cancercriteria. Data were analyzed by SPSS 20 software and shown inArcGIS (Version 10.7).Results: Patients included 46 men (65.7%) and 24 women (34.3%)with a mean age of 60.49 ± 16.08. The general prevalence ofmelanoma was 4.4 in every 1,000,000 persons annually. Mostpatients had skin type III (65.7%), indoor jobs (61.4%), and livedin the city (67.1%). Also, 35.7% had a trauma history, 2.8% hadfamilial melanoma history, and 17.1% had other types of skincancer. Extremities (51.4%), acral lentiginous melanoma (50.1%),Clark IV (61.4%), and inguinal lymph nodes (14.3%) were themost prevalent location, clinical type, pathological level, andinvolved lymph nodes, respectively.Conclusion: Acral lentiginous melanoma and extremitiesinvolvement are prevalent in our region. Most patients go todoctors at an advanced level due to delays in referral, lack offollow-up by patients, lack of recognition at the initial care level,and lack of access to specialty centers. We recommend generalinstructions through media and holding special workshops forphysicians for better familiarity with melanoma.
Zahra Asadi-Kani; Soheila Nasiri; Parvaneh Vessal; Zohreh Tehranchinia; Majidreza Haghzare; Marjan Saeedi
Volume 15, Issue 1 , 2012, , Pages 4-6
Abstract
Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in ...
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Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 with benign melanocytic lesions were enrolled in this study. Estrogen receptor beta expression in benign melanocytic lesions and melanoma was analyzed by using immunohistochemical staining. Result: All melanocytic lesions expressed estrogen receptor beta protein. We found lower estrogen receptor beta protein levels in melanoma. Conclusion: These initial observations, to be confirmed by further comprehensive studies, could suggest a role for estrogen receptor beta in melanoma, pointing at the possibility of using estrogen receptor beta expression for differentiating between malignant and benign lesions.
Azita Nikoo; Mona Masoumeh Naraghi
Volume 15, Issue 1 , 2012, , Pages 15-17
Abstract
Background: Accurate clinical information provided on dermatopathology requisition forms is often very important to achieve correct diagnosis. We searched to evaluate the clinical information actually provided on the Dermatopathology requisition forms of melanocytic lesions submitted to our laboratory. ...
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Background: Accurate clinical information provided on dermatopathology requisition forms is often very important to achieve correct diagnosis. We searched to evaluate the clinical information actually provided on the Dermatopathology requisition forms of melanocytic lesions submitted to our laboratory. Method: The provided clinical information and given microscopic diagnoses were recorded for melanocytic lesions submitted as wet tissue to our dermatopathology department. Result: Biopsy specimens were received from our dermatology clinics at our hospital that were filled in by residents of dermatology. According to ABCDE criteria, 76% of cases had none, 11.5% had one criterion, 19% had two criteria, 5.6% had 3 criteria, 1.1% had 4 criteria, and none had all 5 criteria. Asymmetry was provided in none of the requests, but border irregularity was provided in 7.6% of the time, color 10.1%, diameter 5.9%, and evolution 21.8%. No requisition forms mentioned the ‘‘ugly duckling’’ sign. Conclusion: Actually, most of the requisition forms did not provide the clinical information that is very important for the clinicopathologic correlation in the diagnosis of the pigmented lesions.
N Farsi; AR Firooz; M Rashighi Firoozabadi
Volume 8, Issue 1 , 2004, , Pages 66-69
Abstract
Pigmented Bowens disease is an in situ squamous cell carcinoma, which is seldom reported in white patients. Herein we report a 20-year-old woman with type III skin, who had this lesion on the fourth finger of her right hand, similar to superficial malignant melanoma, clinically. Although dermoscopic ...
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Pigmented Bowens disease is an in situ squamous cell carcinoma, which is seldom reported in white patients. Herein we report a 20-year-old woman with type III skin, who had this lesion on the fourth finger of her right hand, similar to superficial malignant melanoma, clinically. Although dermoscopic evaluation could be helpful, correct diagnosis of non-melanotic origin is done by histological examination. In spite of its rarity, pigmented Bowens disease should be considered in the differential diagnosis of malignant melanoma.
G Faghihi; N Ghanei; P Rajabi; D Taheri
Volume 7, Issue 3 , 2004, , Pages 145-151
Abstract
Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: ...
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Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness of melanoma, and site of the antigen expression. Patients and methods: Paraffin embedded blocks of 50 patients (45 primary and 5 metastatic) with documented diagnosis of melanoma were deparaffinized and immunostained with D0-7 monoclonal antibody. The lesions were divided depending on the degree of the staining as follows: 1) (No staining), 2) Mild (Less than 10%), 3) Moderate (10%-50%), 4) Severe (More than 50%). Results: Of 50 cases, 27 (54%) evaluated skin biopsy specimens belonged to female patients and 23 (46%) skin biopsies were related to male patients. 40% of lesions were graded as no staining. 36% of lesions showed mild staining, 14% moderate and 10% severe staining. Site of expression was exclusively in the cytoplasm. There was no meaningful statistical relationship between severity of staining and the age group, and sex of the patients, type and thickness of melanoma (P>0.05). Conclusion: Mutation in P53 tumor suppressor gene probably occurs in the early stages of melanoma.