Nasiri Soheila; Sedigha Afshin; Farshi Hamideh Moravej; Nabai Leyla; Ebrahimzadeh Simin
Volume 10, Issue 2 , 2007, , Pages 130-134
Abstract
Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials ...
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Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy persons. Vitamin A and E levels were detected with the use of HPLC method. P value less than 0.05 (P<0.05) was considered as significant.Results: Demographic features were matched between groups. Vitamin A level was 1.09×0.27 in control group and 1.08×0.36 in patient group which did not have a meaningful statistical difference (p=0.91). Vitamin E level was 15.52×8.36 in control group and 9.02×5.41 in patient group and the difference was statistically significant (p=0.001). Comparing vitamin A and E levels according to disease severity showed no statistically significant difference.Conclusion: Our results show that vitamin E level in psoriasis patients is lower than healthy group that were matched by age and gender; although vitamin A level was not different between patient and control groups.
A Asilian; MR Omid Ghaemi; A Momeni; F Iraji
Volume 5, Issue 3 , 2002, , Pages 22-28
Abstract
Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of ...
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Background: Acitretin therapy is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin reduced isotretinoin-induced side effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitamin E on the side effects of acitretin. Patients and Methods: Fifty five subjects were randomly assigned to one of the two treatment programs including with acitretin (0.7-1 mg/kg/day) together with either vitamin E (13 IU/kg/day) or alone for 3 months. The incidence of side effects of acitretin in two groups were assessed and compared. Results: The study was completed in thirty-nine patients. Vitamin E did not decreased the incidence of side effects associated with acitretin. Conclusion: Vitamin E did not significantly ameliorate retinoid side affects when combined with 0.7-1 mg/kg of acitretin in treatment of skin disorders.