Yousefi Maryam; Nabaei Leyla; Ghasemnia Hassan; Abolhasani Ehsan; Rahgoshai Rayhaneh; Barikbin Behrooz
Volume 16, Issue 4 , 2013, , Pages 132-136
Abstract
Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over ...
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Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over 40 years with seborrheic keratosis (size: 5-15mm) were instructed to apply 50?g/g calcipotriol ointment twice a day for 12 weeks. The size of the tumor was measured at baseline and after the 12-week period. The size change and improvement were assessed. Result: Thirty out of fifty screened patients were eligible for the study and completed the 12-week course of the study. The mean baseline size of the tumors was 9.30±2.95 mm that decreased to the mean size of 2.02±1.94 mm (P
Fariba Ghalamkarpour; Reza Robati; Ghadeh Ghasir; Mohammad Saeedi; Nahid Mohtasham
Volume 14, Issue 1 , 2011, , Pages 12-15
Abstract
Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. ...
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Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. Methods: Twenty eight patients in two groups were treated with 308nm excimer laser alone (14 patients) and the combination of excimer laser–calcipotriol (14 patients). After 16 sessions, response rate, side-effects and compliance were assessed. Results: Repigmentation rate more than 50% was significantly higher in the laser- calcipotriol group. No differences were seen in complication rate between the two groups. Conclusion: Combination of calcipotriol and 308nm excimer laser might enhance the response rate without increasing treatment complications.
Seirafi Hassan; Farahani Farzaneh; Farnaghi Farshad; Ehsani Amirhooshang; Hashemi Pantea; Farahani Amir
Volume 11, Issue 1 , 2008, , Pages 1-6
Abstract
Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus ...
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Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was given to 26 patients with generalized, symmetrical vitiligo three times weekly. Topical calcipotriol cream was only applied on the lesions located on one side of the body. Treatment was continued until cosmetically acceptable repigmentation occurred, but total cumulative dose of NBUVB did not increase from the mean of 113.4 ± 47.0 j/cm. The efficacy of treatment was evaluated by visually scoring the percentage of regimentation of the lesions at 12-session intervals by an investigator unaware of the side of calcipotriol application. Results: The mean daily dose of NBUVB was 1.4 ± 0.6 j/cm. The median number of exposure for initial regimentation was 26.5 (range 14-38) on the side of combination therapy with calcipotriol and 25.3 (range 20-40) on the other side. After 24 sessions of treatment, 14 patients (53.9%) showed minimal to moderate improvement on the calcipotriol treated side as compared to 21 patients ( 80.8 %) on the other side. After 60 sessions of treatment, 16 patients (16.5 %) showed moderate to marked regimentation on the side of combination therapy with calcipotriol as compared to 19 patients (73 %) on the other side.Conclusion: These findings indicate that concurrent use of topical calcipotriol does not enhance the efficacy of NBUVB in the treatment of vitiligo.