Mohammad Ali Mapar; Sarah Hashemzade; Reza Yaghoobi
Volume 14, Issue 1 , 2011, , Pages 20-24
Abstract
Background: Topical corticosteroids and oral psoralen plus ultraviolet A radiation (PUVA therapy) are two common treatment methods for vitiligo. The aim of this study was to compare the efficacy, complications and patterns of repigmentation of these two methods. Methods: This prospective randomized clinical ...
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Background: Topical corticosteroids and oral psoralen plus ultraviolet A radiation (PUVA therapy) are two common treatment methods for vitiligo. The aim of this study was to compare the efficacy, complications and patterns of repigmentation of these two methods. Methods: This prospective randomized clinical trial was conducted from July 2007 to October 2008. Patients with disseminated vitiligo were divided into two groups. PUVA therapy was administered in one group and topical clobetasol was used in the other group. Results were recorded in 4 categories and therapeutic findings and complications were compared after 24 weeks. Results: Among 37 participants in the PUVA therapy group, 18 (48.6%) patients achieved marked and 14 (37.8%) patients showed good repigmentation. Similarly, among 35 participants in the clobetasol group, 6 (17.1%) patients showed marked and 8 (22.8%) patients showed good repigmentation. treatment complications were observed in 16.2% of the participants in PUVA group and 28.6% of the participants in clobetasol group. The patterns of repigmentation were different in the two groups. Conclusion: PUVA showed better therapeutic effects, and did not cause significant complications. Therefore, it could be used as one of the first line medications in the treatment of vitiligo.
SZ Ghodsi; B Bahar; K Balighi; MR Ranj Kesh
Volume 8, Issue 3 , 2005, , Pages 232-236
Abstract
Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long ...
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Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long time, which may result in several side effects. 5 patients with clinically and histopathologically established cGVHD (3 lichenoid, 1 sclerodermoid and 1 mixed lichenoid-sclerodermoid), who failed to respond to conventional immunosuppressive therapy were treated with psoralen and UVA (PUVA). Treatment was administered in a standard protocol three times a week on non-consecutive days and were continued at least for 12 weeks. All 3 lichenoid cases showed complete improvement. In the sclerodermoid case there was partial response and in the mixed type case the partial response of sclerodermoid lesion and complete response of lichenoid lesions were observed. With the exception of a slight increase in liver transferases, no other adverse reactions occurred. In conclusion, PUVA can be a safe and effective therapy in conjunction with systemic agents for chronic GVHD especially in lichenoid form.
H Seyrafi; F Farnaghi; S Fathabadi
Volume 6, Issue 1 , 2002, , Pages 16-20
Abstract
Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response ...
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Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response of patients to psoralen+UVA (PUVA) therapy. Patients and Methods: 13 patients with resistant atopic dermatitis, older than 10 years, were treated with PUVA, 2 or 3 times a week until complete recovery or maximum of 30 sessions. Rate of recovery was determined according to reduction in 6 signs including itching, erythema, lichenification, xerosis, exfoliation and excoriation at the end of the treatment period and 2 months later. Results: 10 patients (77%) at the end of the treatment and 9 patients (69.2%) two months after that, showed more than 50% recovery. There was no significant relationship between the pretreatment serum IgE levels, site of the lesions, age, sex and phototherapy. The patients with family history of atopic dermatitis showed a better response to the treatment. Conclusion: PUVA is a suitable alternative treatment in resistant cases of atopic dermatitis.
F Iraji; H Azampour; F Fatemi
Volume 3, Issue 4 , 2000, , Pages 2-6
Abstract
Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: ...
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Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 60 patients with palmoplantar eczema referred to skin clinics of Isfahan University in 1376-78 were divided in two equal groups. One group received PUVA-bath and the other one received placebo-bath. Hands or feet or both were soaked for 15 minutes in warm water containing 0.0001% 8-methoxypsoralen or placebo. Then the skin was exposed to sun for 30 minutes. This was performed 4 times a week up to a total of 25 treatments. Results: Excellent or good therapeutic effects were achieved in 86.7% of PUVA bath group but only in 6.7% of placebo (P=0). No phototoxic reactions were observed. Conclusion: PUVA-bath is a safe, cheap, effective and comfortable method in the management of palmoplantar eczema.
