Hajheydari Zohreh; Saeedi Majid; Hosseinzadeh Mohammad
Abstract
Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, ...
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Background: Seborrheic dermatitis is a common chronic relapsing inflammatory skin disease with unknown etiology. Using zinc and selenium supplements have shown some relieving effects on the symptoms of the disease. The present study was conducted to determine the relationship between serum selenium, zinc, and copper levels with seborrheic dermatitis. Methods: A prospective case-control study was performed on 30 patients with seborrheic dermatitis and 30 age and sex-matched healthy volunteers as a control group. Trace elements were measured by atomic absorption spectrophotometer in both groups. Results: The mean serum selenium, zinc, and copper levels were 98.90 ± 27.61 ?g/dL, 91.27 ± 10.84 ?g/dL, and 100.9 ± 20.06 ?g/ dL in case groups, respectively. In the control group, the mean serum selenium, zinc, and copper levels were 91.61 ± 15.74 ?g/dL, 94.03 ± 11.11 ?g/dL, and 96.5 ± 15.82 ?g/dL, respectively. There was no significant difference between the mean serum selenium, zinc, and copper levels in case and control groups (P>0.05). Conclusions: Although no statistically significant relationship was observed in serum selenium, zinc, and copper levels between the cases and controls, the serum selenium level among patients in case group was higher than that in the healthy subjects.
A Kouhkan; Z Pour Pak; R Safar Ali Zadeh; Sh Teimourian; AR Firooz
Volume 9, Issue 2 , 2006, , Pages 143-149
Abstract
Background and aim: Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease usually observed in patients with other allergies. Decreased selenium levels and improvement with selenium supplement are reported in AD. The aim of this study was to compare serum and whole blood selenium in ...
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Background and aim: Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease usually observed in patients with other allergies. Decreased selenium levels and improvement with selenium supplement are reported in AD. The aim of this study was to compare serum and whole blood selenium in children with AD and control group.Materials and Methods: In an age-sex matched case-control study, 46 children with AD (according to Rajka & Hanifin criteria) and 46 controls were evaluated. The severity of AD was determined based on SCORAD index. Serum and whole blood selenium levels were measured and compared between two groups by atomic absorption spectroscopy. Chi-square and t tests were used for data analysis and P<0.05 was considered as significant.Results: Forty-six patients with age of 2.57±2.6 years and 46 controls with age of 2.63±2.6 years, each consisting of 24 boys and 22 girls were included (P>0.05). Mean serum selenium in patients (72.58±16.5 ng/ml) was significantly lower than controls (84.8±15.6 ng/ml) (P=0.0001). Mean whole blood selenium in patients (88.07±19.0 ng/ml) was significantly lower than controls (99.38±19.3 ng/ml)(P<0.001). Low serum selenium levels (less than 63 ng/ml) were observed in 28.3% of patients and 10.9% of controls (P<0.05). Low whole blood selenium levels (defined as less than 75.5 ng/ml) were observed in 30.4% of patients and 15.2% of controls (P>0.05). No significant correlations were observed between serum and whole blood selenium and severity of AD.Conclusion: The results confirm other studies that showed low selenium levels in AD. Our findings suggest that low selenium level may be involved in the pathophysiology of AD in childhood, and indicate nutritional status especially selenium levels might be a potentially useful strategy for the recognition and treatment of these patients.
V Feizi; H Mortazavi; B Barik Bin; M Yousefi; AR Ranjbar
Volume 8, Issue 3 , 2005, , Pages 195-200
Abstract
Background: Autoimmune mechanisms are involved in the etiology of Alopecia areata. It is also shown that Selenium has some effects on regulation of autoimmune mechanisms. Objective: To compare the plasma level of Selenium between those with and without Alopecia areata. Patients and Methods: In this case-control ...
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Background: Autoimmune mechanisms are involved in the etiology of Alopecia areata. It is also shown that Selenium has some effects on regulation of autoimmune mechanisms. Objective: To compare the plasma level of Selenium between those with and without Alopecia areata. Patients and Methods: In this case-control study, 29 patients with Alopecia areata referred to Razi hospital in Tehran, and 29 persons without this disease were selected consequently. Plasma level of Selenium was determined and compared between the groups. Results: The mean age of cases was 24.9±10.5 and of controls was 29.1±10.5 years. In both groups 15 (51.7%) patients were male and 14 (48.3%) of them were female. The mean plasma Selenium level in cases was significantly lower than what was observed in controls (62.1±13.3 g/l vs. 88.3±13.2 g/l, P<0.0005). Conclusion: This study indicated that mean plasma Selenium level in patients with Alopecia areata was lower than those without this disorder. It is recommended to evaluate the effects of adding Selenium to dietary regimen of patients with Alopecia areata.
Z Pourpak; AR Ranjbar; AH Farhoodi; M Movahedi; A Koohkan
Volume 6, Issue 2 , 2003, , Pages 40-52
Abstract
Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were ...
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Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were increased and serum total IgE were decreased in all patients. These results show that selenium is in the cells, therefore selenium could be a suitable and effective treatment. Further studies are required with increased subjects, different dosages and treatment duration to reach more definite results.
