Lotfabadi Pegah; Maleki Farzaneh; Gholami Ali; Yazdanpanah Mohammad Javad
Volume 18, Issue 4 , 2015, , Pages 151-155
Abstract
Background: Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in the treatment of anogenital warts.Methods: This randomized ...
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Background: Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in the treatment of anogenital warts.Methods: This randomized clinical trial was conducted on patients with anogenital warts. The patients were divided into two groups; one group was treated with liquid nitrogen and theother with 70% trichloroacetic acid. In both groups, the treatment was done every two weeks until complete disappearance of the lesions or for 6 sessions.Results: In this study, 68 patients with anogenital warts were studied. After the 6th session, the cure rate of in the patients treated with trichloroacetic acid (94.1%) was higher than the patients treated with cryotherapy (85.3%) (P>0.05).Conclusion: It seems that cryotherapy and trichloroacetic acid therapy have similar results in the treatment of anogenital warts.
Amanjot Kaur Arora; Alka Dogra; Sunil Kumar Gupta
Volume 17, Issue 3 , 2014, , Pages 85-90
Abstract
Background: Plantar warts may be refractory to any form of treatment and are associated with pain and a decreased quality of life. There are very few randomized controlled studies that focuson the treatment of plantar warts. Cryotherapy and radiofrequency ablation (RFA) have been used ...
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Background: Plantar warts may be refractory to any form of treatment and are associated with pain and a decreased quality of life. There are very few randomized controlled studies that focuson the treatment of plantar warts. Cryotherapy and radiofrequency ablation (RFA) have been used in the treatment of this recalcitrant condition. However, no data exists comparing the efficacy ofthese treatment options in the treatment of plantar warts. The aim of the study was to compare the efficacy of cryotherapy and RFA in the treatment of plantar warts.Method: Fifty patients with a clinical diagnosis of plantar warts were included in the study. They were randomly divided into two groups of 25 patients. After paring the warts, Group A wastreated with cryotherapy with nitrous oxide and Group B was treated by RFA of warts every 2 weeks for a maximum period of 12 weeks. The results of the two groups were compared atthe end of 12 weeks.Result: Fifty patients had a total of 212 warts. Eighty four percent (21/25) of the patients receiving RFA experienced subjective benefits within 2 sessions whereas in the cryotherapy group, 72% (19/25) of the patients required three to four sessions to experience subjective benefits (p = 0.00189). Eighty four percent (21/25) of the patients and 91.6% (121/132) of the warts in theRFA group achieved complete clearance by the end of 12 weeks whereas only 32% (8/25) of the patients and 31.25 % (25/80) of the warts receiving cryotherapy achieved complete clearance bythe end of 12 weeks (p = 0.00681).Conclusion: Radiofrequency ablation is more effective than cryotherapy in the treatment of plantar warts and gives quicker subjective and objective results.
Radmanesh Mohammad; Azar-Beig Mohsen
Volume 16, Issue 2 , 2013, , Pages 49-52
Abstract
Background: The cold-induced inflammation of cryotherapy mayalter the immunologic processes and structural components ofthe hair follicles responsible for AA. The aim of this study was tostudy the efficacy of cryotherapy in alopecia areata, and totalis.Method: Forty-four patients with recalcitrant scalp ...
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Background: The cold-induced inflammation of cryotherapy mayalter the immunologic processes and structural components ofthe hair follicles responsible for AA. The aim of this study was tostudy the efficacy of cryotherapy in alopecia areata, and totalis.Method: Forty-four patients with recalcitrant scalp alopeciaareata or totalis were treated with cryotherapy. The cryo-systemchosen was a closed contact CO2 system with metallic probes.The patients were evaluated for 4-8 weeks for hair growth.Satisfactory hair growth after 8 weeks was an indication forperforming cryotherapy for the remaining untreated areas.Result: Varying degrees of hair growth were detected in 52.50%of the patients four weeks and in 65.90 % eight weeks aftertreatment. About 38.64% of the patients showed more than 50%hair regrowth 8 weeks after therapy.Conclusion: Cryotherapy is effective for about two-thirds of thepatients with alopecia areata, many of whom are unresponsiveto conventional therapies.
Simin Shamsi Meymandi; Manzumeh Shamsi Meymandi; Soodabeh Zandi; Shahriar Dabiri; Mahin Aflatoonian
Volume 14, Issue 2 , 2011, , Pages 42-47
Abstract
Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy ...
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Background: Cutaneous leishmaniasis (CL) is a major world problem. Several types of treatment regimens have been suggested. Imiquimod demonstrated a leishmanicidal activity by increasing local cytokine production. The aim of this study was to determine the efficacy of topical 5% imiquimod with cryotherapy vs. intralesional meglumine antimoniate (MA) in treatment of anthroponotic (dry type) CL. Method: This is a prospective, randomized, open trial study (from Iran) from September 2008 to September 2010, including 50 patients (25 patients in the combined imiquimod and cryotherapy group and 25 patients in the intralesional MA group). Patients were randomly assigned to receive combined cryotherapy biweekly with imiquimod three times per week or intralesional MA weekly until complete cure or up to 12 weeks, whichever earlier. The primary end point was clinical cure, defined as complete re-epitelialization of 100%, complete flattening of induration compared with baseline at weeks 2, 6, 12 and follow up were done 1, 2 and 3 months after complete cure. Results: 50 participants divided into 25 patients in group A and 25 patients in group B completed the study. Complete cure was 65.5% (16/24 patients) in group A and 83.3% (19/23 patients) in group B. No complication was detected in patients treated with MA. Pain and eczematous reaction were detected by 4 patients and local infection in 1 patient treated with imiquimod. Conclusion: Although Meguimine antimoniate seems to be a more effective therapy for cutaneous leishmaniasis, this study revealed no significant difference in clinical response between combination of imiquimod and cryotherapy with intralesional MA in patients with cutaneous leishmaniasis in an endemic area of L. tropica.
Farideh Golforoushan; Hamideh Azimi; Mohamad Sadeghi; Neda Yousefi; Mohamad Goldust
Volume 13, Issue 2 , 2010, , Pages 47-50
Abstract
Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently ...
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Introduction: Solar lentigo is local and benign proliferation of melanocytes which is common in old individuals and creates a major concern considering beauty. Despite several and somehow expensive treatments such as laser and cryotherapy, chemical peeling with Trichloroacetic Acid (TCA) has recently attracted attentions considering its low cost and availability. The present study was designed to compare the efficacy and side effects of Trichloroacetic Acid (TCA) 35% and cryotherapy in the treatment of solar lentigo.Methods: This randomized clinical trial was performed on 35 individuals with solar lentigo on their hands. First, images were taken from both hands. Then, one side was treated with cryotherapy and the other side was treated with TCA 35%, randomly. This treatment was repeated after one month. The imaging was repeated at the end of the second month and both sides were compared with previous images regarding the degree of the improvement (lightening) of the lesions and the resultant side effects. Descriptive statistical methods and 2-chi square relation were used for analyzing data with SPSS 16.Results: The results demonstrated that cryotherapy resulted in more than 50% recovery (lightening >50%) in 60% of the cases which was statistically significant (P<0.05). In contrast, TCA 35% yielded more than 50% recovery in 46% of the cases which was significant, too. Comparing these modes of treatments regarding 50% recovery showed no statistically significant difference (P=0.219). Side effects were seen in 40% and 13.3% of the individuals who used cryotherapy and TCA 35%, respectively, which was statistically significant (P<0.05).Conclusions: According to the findings of the research, TCA 35%, compared to cryotherapy, has similar efficiency but fewer side effects in the treatment of solar lentigo.
Seirafi Hassan; Fateh Soheil; Farnaghi Farshad; Ehsani Amir Hooshang; Noormohammadpoor Pedram
Volume 13, Issue 1 , 2010, , Pages 1-5
Abstract
Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to ...
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Background: Although cryotherapy is still the first-line therapy for solar lentigines, due to side effects such as post-inflammatory hyperpigmentation (PIH), especially in patients with darker skin types, pigment specific lasers should be considered as initial treatment. The aim of this study was to evaluate the efficacy and safety of cryotherapy in comparison with 595-nm pulsed dye laser (PDL) with cutaneous compression in the treatment of solar lentigines. Method: Twenty two patients (skin type II- IV) with facial or hand lentigines completed this study. Lesions of one side of the face or each hand were randomly assigned and treated with either cryotherapy or PDL. Treatments were performed with radiant exposures of 10 J/cm2, 7mm spot size and 1.5ms pulse duration with no epidermal cooling. Photographs were taken before treatment and one month later. The response rate and side effects were compared. Results: PDL was more likely to produce substantial lightening of solar lentigines than cryotherapy, especially in skin types III and IV (n=8, n=9; P0.05). PIH was only seen in the cryotherapy group. PDL group only showed minimal erythema. No purpura was observed. Conclusion: PDL with compression is superior to cryotherapy in the treatment of solar lentigines in darker skin types.
Layeh Pouran; Pezeshkpour Fakhr-o-Zaman; Shakeri Mohammad Taghi; Mousavi Sareh
Volume 10, Issue 3 , 2007, , Pages 174-180
Abstract
Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and ...
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Background and aim : Genital wart is a common sexually transmitted disease caused by different types of human papilloma virus (HPV). Cryotherapy is one of the most commonly used treatment options. Trichloroacetic acid (TCA) is another therapy commonly used in treatment of genital warts.Materials and methods: The objective of his study was to evaluate and compare the efficacy and adverse effects of TCA and cryotherapy (with liquid nitrogen). Sixty female patients with external genital warts were enrolled into this prospective clinical trial. Thirty of them received topical solution of 80% TCA and the other 30 received cryotherapy with liquid nitrogen, once a week, until complete clearance of lesions or a maximum duration of 8 weeks. Results: Twenty-seven patients (93.1%) of those who received up to eight treatments of cryotherapy had complete clearance of their warts, compared with 28 (96.5%) of patients who were treated with TCA (P>0.05). The mean duration for complete clearance was 4.4 weeks for TCA and 5.2 weeks for cryotherapy (P=0.5). Patients who received TCA experienced a significantly greater number of local inflammatory reactions (P=0.01). Conclusion: Both cryotherapy and TCA are effective treatments. In comparison, TCA showed its efficacy earlier during the course compared to cryotherapy. TCA is more likely to cause adverse reactions.
Raziee Morteza; Balighi Kamran; Shabanzadeh-Dehkordi Hossein; Rabati Reza Mahmoud
Volume 9, Issue 4 , 2006, , Pages 308-312
Abstract
Background and aim: Solar lentigines are common sun-induced benign melanocytic proliferations that present a significant cosmetic problem for many middle- aged and elderly patients. The purpose of this study was to assess the efficacy of cryotherapy in comparison to trichloroacetic acid (TCA) 33% on ...
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Background and aim: Solar lentigines are common sun-induced benign melanocytic proliferations that present a significant cosmetic problem for many middle- aged and elderly patients. The purpose of this study was to assess the efficacy of cryotherapy in comparison to trichloroacetic acid (TCA) 33% on solar lentigines on the back of the hands (SLBH).Materials and Methods: Each hand of 33 patients with SLBH was treated randomly with either cryotherapy or TCA 33% solution. Photographs of the hands were taken prior to and two months following the treatment. Therapeutic response and side-effect were compared using chi-square test.Results: Twenty five patients completed the study. Cryotherapy was more likely to produce substantial lightening of the solar lentigines than TCA 33% solution (P=0.025) but was more painful and took longer to heal. Post inflammatory hyperpigmentation (PIH) was almost equal in two types of treatment. Statistically, better results were seen in lower Fitzpatrick's skin types (P<0.01).Conclusion: Cryotherapy appears to be superior to TCA 33% solution in the treatment of SLBH particularly in lower Fitzpatrick skin types. PIH is the major complication of both particularly in higher Fitzpatrick skin types. Generally, the major criterion for treatment of SLBH with cryotherapy or TCA is Fitzpatrick's skin type.
Edalatkhah Hassan; Khalilollahi S. Hojat; Sani Nayyereh Amini; Taher Athar
Volume 9, Issue 4 , 2006, , Pages 313-318
Abstract
Background and aim: Warts are the most common clinical presentation of human papilloma virus infection of human skin and mucosa. They are more common on hand, foot, face and genital area. They are benign skin colour lesions with different clinical forms. There is no specific treatment for them. In this ...
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Background and aim: Warts are the most common clinical presentation of human papilloma virus infection of human skin and mucosa. They are more common on hand, foot, face and genital area. They are benign skin colour lesions with different clinical forms. There is no specific treatment for them. In this trial the therapeutic effect of intralesional injection of bleomycin and cryotherapy on common warts of hands and feet was compared.Materials and Methods: Fifty-two subjects entered the study but 44 patients completed the trial. Warts were treated by intralesional injection of bleomycin 0.5 mg/ml or liquid nitrogen on symmetric aspects of both hands and feet. We used cryo-spray gun for application of liquid nitrogen. Treatment was repeated every 2 weeks for a maximum of three times. Treatment was done by a dermatologist and treatment response was evaluated by another dermatologist. Collected data were analyzed by SPSS software.Results: In this trial 23 female and 21 male patients were studied. Totally, 253 warts were treated by cryotherapy and 226 warts by intralesional bleomycin. Cure rate was 73.1% for cryotherapy and 87.6% for intralesional bleomycin (P<0.001).Conclusion: Cure rate for intralesional bleomycin was higher than cryotherapy. Intrelesional bleomycin therapy is an effective and safe treatment for common warts.
H Edalat Khah; AR Mohebbi Pour; F Eghtedari
Volume 9, Issue 2 , 2006, , Pages 127-131
Abstract
Background and aim: Pyogenic granuloma is a small, red, benign vascular tumor usually occuring after penetrating injury in skin. Different therapies such as laser, surgery and electro surgery have been offered for its treatment. Each of these therapies has advantages and disadvantages. In this study, ...
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Background and aim: Pyogenic granuloma is a small, red, benign vascular tumor usually occuring after penetrating injury in skin. Different therapies such as laser, surgery and electro surgery have been offered for its treatment. Each of these therapies has advantages and disadvantages. In this study, we evaluated the therapeutic effects of cryotherapy and electrocautery on pyogenic granuloma.Materials and Methods: This clinical trial was performed on 50 patients who had pyogenic granuloma. In 25 patients cryotherapy was used with liquid nitrogen every ten days for a maximum of 3 sessions. Electrocautery was done by another dermatologist, and the lesion was destroyed in one session. Patients were followed for one month after treatment. T test and X2 were used for data analysis.Results: The mean age of patients in cryotherapy group and in electrocautery group were 21.8±17/1 and 28/7±17/7 years , respectively (P>0.05). Number of treatment sessions were 2.2±0.8 in cryotherapy and 1/1±0.3 in electrocautery group (P<0.0001). Cure was observed in 100% of patients treated by electracautery method and in 77% treated by cryotherapy method (P=0.01).Conclusion: Electrocautery is more effective than cryotherapy, but treatment with cryotherapy also is very effective, and can be used mainly in children, pregnant women, large lesions and those who are afraid from electrocautery.
MA Nilforoush Zadeh; F Jaffari; B Malek Afzali
Volume 7, Issue 3 , 2004, , Pages 136-139
Abstract
Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment ...
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Background: In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis (CL), yet. Objective: To compare the efficacy of intralesional Glucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment and intralesional Glucantime in the treatment of CL. Materials and methods: 157 patients with CL were randomly allocated into 2 groups, 81 patients in group 1 were injected with intralesional Glucantime (Twice a week up to healing to the lesions or maximum 6 weeks). 76 patients in group 2 were treated with Paramomycin ointment (15% in 10% urea, twice a day), cryotherapy (Maximum 3 times 2 weeks) apart and injection of intralesional Glucantime (Once a week), for the same period as group 1. Results: After 6 weeks, complete cure rate in group 2 (89.5%) was significantly more than group 1 (70.4%) (P<0.05). Conclusion: Our results indicating of more efficacy of the triple therapy is in accordance with the previous studies of combined cryotherapy and Paramomycin. It could be recommended as a better treatment modality for CL wherever possible.
A Asilian; A Momeni; G Faghihi; V Sadeghi; M Sadeghi; H Sadeghi
Volume 6, Issue 2 , 2003, , Pages 30-33
Abstract
Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and ...
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Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and Methods: 300 patients with CL were randomly assigned to two treatment groups in this clinical trial. In group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional glucantime injection every 2 weeks. In group 2, 200 patients with 230 lesions were treated only with cryotherapy, every 2 weeks. Both groups were followed for 6 months after last treatment. Results: Clinical and parasitological cure were seen in 90% of cases in group 1 and 57.3% in group 2 (P<0.05). Conclusion: Combination of cryotherapy and intralesional glucantime injection is an effective treatment modality in early lesions of CL.
M Valikhani; AR Zaker; M Zaker
Volume 5, Issue 4 , 2002, , Pages 16-19
Abstract
Background: Common wart is one of the most prevalent skin diseases, caused by human papilloma virus. Numerous therapeutic modalities have been used in the treatment of warts. Objectives: This study was designed to evaluate and compare the efficacy of 5% 5-fluorouracil (5-FU) ointment with cryotherapy ...
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Background: Common wart is one of the most prevalent skin diseases, caused by human papilloma virus. Numerous therapeutic modalities have been used in the treatment of warts. Objectives: This study was designed to evaluate and compare the efficacy of 5% 5-fluorouracil (5-FU) ointment with cryotherapy in the treatment of common warts of hands. Patients and Methods: In a single blind, prospective clinical trial, 30 patients with bilateral common warts of hands referred to Dermatology Clinic of Razi Hospital, were recruited. The lesions on one hand of the patients were treated by cryosurgery and on the other hand with 5% 5-FU ointment twice daily for about 12 weeks. Results: After 12 weeks, 93% of patients treated by cryotherapy (The mean treatment period 7.5 weeks), and 66.7% of patients received 5% 5-FU ointment (The mean treatment period 6.9 weeks) were completely cured. No significant side effects were noted in patients who received 5% 5-FU ointment. Conclusion: 5% 5-FU ointment can be used as appropriate, household and inexpensive treatment in the management of common warts.
A Asilian; F Salehi
Volume 5, Issue 2 , 2002, , Pages 33-38
Abstract
Cryotherapy is a simple, safe and effective method for many benign and malignant skin diseases. If applied with an appropriate technique, the results will be very satisfactory and the complications will be very low. Herewith we will discuss cryotherapy and its applications in dermatology and review the ...
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Cryotherapy is a simple, safe and effective method for many benign and malignant skin diseases. If applied with an appropriate technique, the results will be very satisfactory and the complications will be very low. Herewith we will discuss cryotherapy and its applications in dermatology and review the advantages and disadvantages of this technique.
M Mirshams Shahshahani; M Danesh pazhooh; A Mirshekari
Volume 3, Issue 3 , 2000, , Pages 14-17
Abstract
Background: Pyogenic granuloma is a benign vascular proliferation that is often related to minor trauma by the patient. Objective: Evaluation of the efficacy of cryotherapy in the treatment of pyogenic granuloma. Patients and Methods: Hundred and forty-six patients with pyogenic granuloma were treated ...
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Background: Pyogenic granuloma is a benign vascular proliferation that is often related to minor trauma by the patient. Objective: Evaluation of the efficacy of cryotherapy in the treatment of pyogenic granuloma. Patients and Methods: Hundred and forty-six patients with pyogenic granuloma were treated by cryosurgery using liquid nitrogen and cotton tip applicator in an open clinical trial. This study was carried out in Razi Hospital, Tehran University of Medical Sciences, in 1377. Patients were followed for at least 3 months after complete resolution. Results: Hundred and thirty-five patients completed the study. Complete resolution was achieved in all patients. Treatment sessions ranged from one to 4 (Mean 1.6±0.8) sessions. 88.2% of patients needed only 1 or 2 treatment sessions. Recurrence of lesions occurred in 3 patients in whom retreatment led to complete resolution. Conclusion: Cryotherapy can be regarded as a completely efficient method in treatment of pyogenic granuloma.