Saman Mohammadi; Maryam Khalili; Mahin Aflatoonian; Rezvan Amiri; Zahra Sharif; Saeedeh Farajzadeh; Azadeh Mohebbi
Abstract
Background: Atopic dermatitis is a chronic relapsing inflammatoryskin disease that has possible associations with other diseases suchas allergic conditions, autoimmune skin diseases, and systemicdiseases. We evaluated the prevalence of alopecia areata andthyroid autoimmunity in children with atopic dermatitis.Methods: ...
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Background: Atopic dermatitis is a chronic relapsing inflammatoryskin disease that has possible associations with other diseases suchas allergic conditions, autoimmune skin diseases, and systemicdiseases. We evaluated the prevalence of alopecia areata andthyroid autoimmunity in children with atopic dermatitis.Methods: This was a cross-sectional study on 124 children(62 children with atopic dermatitis and 62 healthy children).Demographic features of the participants and duration of diseasein children with atopic dermatitis were recorded. Antithyroidperoxidase and thyroid stimulating hormone were evaluated inboth groups. Odds ratio (OR) and 95% confidence interval (CI)were calculated to estimate relative risk. The chi-squared testand analysis of variance test (ANOVA) were used to evaluatethe association of thyroid autoimmunity with the demographicand clinical features of patients.Results: Thyroid autoimmunity was only detected in atopicdermatitis children and not in the control group, and the differencewas statistically significant [OR = 4.32, 95% CI = 2.15–10.81,P = 0.04). Furthermore, overt thyroid disease was significantlymore common in the atopic dermatitis group compared withthe control group (OR = 4.46, 95% CI = 1.15–17.24, P = 0.03). Apersonal history of alopecia areata was also significantly morecommon in the atopic dermatitis group (OR = 4.46, CI = 1.17–15.29,P = 0.030). In addition, there was no significant difference betweenthyroid autoimmunity and overt thyroid disease in the patients’severity of atopic dermatitis and demographic features (P > 0.05).Conclusion: Patients with atopic dermatitis had a significantlyhigher percentage of thyroid autoimmunity, overt thyroid disease,and alopecia areata than the control group.
Herwinda Brahmanti; Aunur Rofiq; Moch Cholis; Unundya Trijayanti; Sasi Purwanti
Abstract
Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 ...
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Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited in Indonesia, particularly in Malang city. The objective of the present study was to understand the association of LL-37 and IL-31 serum levels with SCORing Atopic Dermatitis (SCORAD) in atopic dermatitis patients.Methods: The present research is an analytical observational cross-sectional study with 30 atopic dermatitis patients as subjects. Through a consecutive sampling method, samples were collected from the outpatient clinics of dermatovenereology and pediatric department, Dr. Saiful Anwar General Hospital (RSSA), Malang, Indonesia. LL-37 and IL-31 serum levels were examined via Enzyme-Linked Immunosorbent Assay (ELISA) method. Subjects were allocated into two groups of atopic dermatitis severity, mild and moderate-severe, based on the SCORAD index.Results: Based on the Pearson correlation test, there was no correlation between LL-37 serum level, IL-31 serum level and the SCORAD score (r=-0.238 with P=0.205, and r=0.15 with P=0.939).Conclusion: LL-37 and IL-31 serum levels are not associated with atopic dermatitis severity.
Mohammad Radmanesh; Mehrana Sharifi; Sedigheh Shafiei
Volume 14, Issue 1 , 2011, , Pages 25-28
Abstract
Background: Lichen simplex chronicus (LSC), nodular prurigo (NP), and neurotic excoriation (NE) are considered as psychogenic pruritus disorders. Atopic dermatitis (AD) is also classified by some as a psychocutaneous disorder to point out the influence of psychologic factors in its recurrence, persistence ...
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Background: Lichen simplex chronicus (LSC), nodular prurigo (NP), and neurotic excoriation (NE) are considered as psychogenic pruritus disorders. Atopic dermatitis (AD) is also classified by some as a psychocutaneous disorder to point out the influence of psychologic factors in its recurrence, persistence and precipitation. AD and psychogenic pruritus share many common features including immunohistology, clinical course and their psychiatry. The aim of this assay was to study the correlation between psychogenic pruritic disorders and atopy.Methods: Ninty-two patients with psychogenic pruritus, including 57 cases of LSC, 27 cases of NE and 8 cases of NP, were referred to us within a period of 18 months. The patients were studied in our private Dermatology-Psychiatry liaison Clinic in order to find out the correlation of those disorders with atopy. Ninty-two healthy individuals with no apparent dermatologic disoder were selected from the general population as controls. Patients were considered atopic if they had the history of dermatitis, asthma or hay fever with the typical age of onset, distribution, seasonal variation, and history of remission and recurrence. Atopy was investigated by physical examination and thorough history by completing a questionnaire containing all reported major and minor criteria in the literature.Results: Forty five out of 92 patients with psychogenic pruritic disorders (48.9%) were atopic which was significant in comparison with the control group (20.6%) (p<0.0001, odd ratio = 3.68 (3.29 – 4.24), and CI = 99%).Conclusion: This study showed that atopic state seemed to be more common in patients with psychogenic pruritic disorders.
Nuzhatun Nisa; Masood Qazi; Iffat Shah
Volume 14, Issue 1 , 2011, , Pages 29-31
Abstract
In any description of leg ulcers in systemic lupus erythematosus (SLE), pyoderma gangrenosum (PG) earns a mention at least for its being quite rare in such patients. The causative role of aPL (antiphospholipid antibody) in dermatological manifestations of SLE is undermined by the occurrence of PG in ...
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In any description of leg ulcers in systemic lupus erythematosus (SLE), pyoderma gangrenosum (PG) earns a mention at least for its being quite rare in such patients. The causative role of aPL (antiphospholipid antibody) in dermatological manifestations of SLE is undermined by the occurrence of PG in aPL negative SLE patients. To the best of our knowledge, there are only two reports of PG in aPL negative SLE patients; in one, PG preceded the diagnosis of SLE by several years while the other was associated with the reactivation of the disease in an already diagnosed SLE patient. In view of the rarity of this association, we hereby present another similar case to substantiate the documentation of the association of the entities.
Farajzadeh Saeedeh; Bazargan Nasrin; Shahesmaeili Armita; Shahrbabaki Azam Gholami; Fekri Ali Reza
Volume 13, Issue 2 , 2010, , Pages 33-36
Abstract
Background: The role of food allergy in atopic dermatitis (AD) is controversial. The aim of this study was to determine the frequency of food allergens in children with AD. Method: Fifty one atopic dermatitis children aged 6 months to 5 years entered our study. The severity of AD was determined by scoring ...
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Background: The role of food allergy in atopic dermatitis (AD) is controversial. The aim of this study was to determine the frequency of food allergens in children with AD. Method: Fifty one atopic dermatitis children aged 6 months to 5 years entered our study. The severity of AD was determined by scoring index of AD (SCORAD). Skin prick test (SPT) was done using 15 allergens including the white of the egg, yolk, peanut, kiwi, strawberry, cow's milk, walnut, fish, banana, wheat, orange, tomato, cereals, apple and cocoa. Results: Thirty four patients (66.7%) had a positive reaction to one or more allergens and in 17 patients (33.3%), the SPT was negative to all allergens. Eleven patients (21.6%) had a positive SPT to one food allergen, 9 patients (17.6%) to two allergens, 9 patients (17.6%) to three allergens, 3 patients (5.9%) to four allergens, 1 patient (2%) to seven allergens and 1 patient (%2) to ten allergens. The most common food allergen among 15 allergens was white egg in 19 patients (37.3%). Yolk was the second most common allergen in 11 patients (21.6%). The relationship between the severity of the SPT with AD severity was observed only for cow's milk, which showed a reverse relationship (R=-0.337). Conclusion: White egg was the most common allergen in all ages and both sexes. Food allergens may play a role in the pathogenesis of atopic dermatitis.
Farajzadeh Saeedeh; Zandi Soodabeh; Vares Behrooz; Sharifzadeh Mahdiyeh; Fekri Ali-Reza
Volume 11, Issue 1 , 2008, , Pages 21-24
Abstract
Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of ...
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Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in atopic dermatitis patients with the control group in an outpatient clinic in Kerman.Methods: This was a case – control study done on 459 patients with atopic dermatitis, who were diagnosed based on Hanifin & Rajka criteria and 400 healthy subjects without immunosuppression as our control group. The frequency of leishmaniasis was investigated in both groups according to age, gender and residential area.Results: Among 459 atopic dermatitis patients, 232 were female and 227 were male. Control group consisted of 232 males and 168 females. The mean age of the atopic dermatitis patients and the controls was 9.2 and 13.3 years, respectively (p0.05%). There was no statistically significant difference in clinical presentations of leishmaniasis between two groups.Conclusion: In this study there was no significant relationship between leishmaniasis and atopic dermatitis. This finding can be due to the small sample size or the difference between case and control groups regarding age.
Z Pour Pak; AR Firooz; L Sedighi Pour; A Afrooz; Gh.A Afrooz; B Ghobari; A Kazem Nejad
Volume 9, Issue 3 , 2006, , Pages 233-241
Abstract
Background and aim: Atopic dermatitis (AD) is a chronic disorder that is most common in early childhood. Both immunological and psychological factors are important in AD pathogenesis and should therefore be taken into account. The aim of this study was to compare behavioral characteristics of 30 infants ...
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Background and aim: Atopic dermatitis (AD) is a chronic disorder that is most common in early childhood. Both immunological and psychological factors are important in AD pathogenesis and should therefore be taken into account. The aim of this study was to compare behavioral characteristics of 30 infants (3-12 month-old) with AD with 40 controls.Materials and Methods: The infants with the definite diagnosis of atopic dermatitis referring to Children Medical Center and Center for Research & Training in Skin Diseases & Leprosy were included in the study. The severity of atopic dermatitis was determined by SCORAD criteria. For assessing behavioral characteristics Infant Behavior Questionnarie (IBQ) for measuring 11 scales of behavioral characteristics was used. Questionnaires were filled by the researchers with the cooperation of the patents or the child care givers.Results: The AD group showed significantly higher scores in perceptual sensitivity, soothability and high pleasure, but not other characteristics.Conclusion: Infants with AD tend to have higher perceptual sensitivity to the environment around them and show more pleasure and excitement when subjected to an intense, rapid, novel or incogruit stimuli compared with non atopic infants.
M Nasiri Kashani; H Mortazavi; S Amini
Volume 9, Issue 3 , 2006, , Pages 264-269
Abstract
Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact ...
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Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Methods: This descriptive, cross sectional study was performed on patients with contact or atopic dermatitis in 2003-2004 with European Standard Series patch test containing 24 allergens.Results: In this study 223 patients were tested with a mean age of 31 years (SD=12). The most common involved location was hand (59%). The most common allergens were nickel sulphate (23/2%), cobalt (11/4%) and thiuram (8/3%).Conclusion: Nickel sulphate was the most common contact allergen in this study.
A Kouhkan; Z Pour Pak; R Safar Ali Zadeh; Sh Teimourian; AR Firooz
Volume 9, Issue 2 , 2006, , Pages 143-149
Abstract
Background and aim: Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease usually observed in patients with other allergies. Decreased selenium levels and improvement with selenium supplement are reported in AD. The aim of this study was to compare serum and whole blood selenium in ...
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Background and aim: Atopic dermatitis (AD) is a chronic, inflammatory, pruritic skin disease usually observed in patients with other allergies. Decreased selenium levels and improvement with selenium supplement are reported in AD. The aim of this study was to compare serum and whole blood selenium in children with AD and control group.Materials and Methods: In an age-sex matched case-control study, 46 children with AD (according to Rajka & Hanifin criteria) and 46 controls were evaluated. The severity of AD was determined based on SCORAD index. Serum and whole blood selenium levels were measured and compared between two groups by atomic absorption spectroscopy. Chi-square and t tests were used for data analysis and P<0.05 was considered as significant.Results: Forty-six patients with age of 2.57±2.6 years and 46 controls with age of 2.63±2.6 years, each consisting of 24 boys and 22 girls were included (P>0.05). Mean serum selenium in patients (72.58±16.5 ng/ml) was significantly lower than controls (84.8±15.6 ng/ml) (P=0.0001). Mean whole blood selenium in patients (88.07±19.0 ng/ml) was significantly lower than controls (99.38±19.3 ng/ml)(P<0.001). Low serum selenium levels (less than 63 ng/ml) were observed in 28.3% of patients and 10.9% of controls (P<0.05). Low whole blood selenium levels (defined as less than 75.5 ng/ml) were observed in 30.4% of patients and 15.2% of controls (P>0.05). No significant correlations were observed between serum and whole blood selenium and severity of AD.Conclusion: The results confirm other studies that showed low selenium levels in AD. Our findings suggest that low selenium level may be involved in the pathophysiology of AD in childhood, and indicate nutritional status especially selenium levels might be a potentially useful strategy for the recognition and treatment of these patients.
H Ansarin; F Shafi Khani; A Taher Pour
Volume 8, Issue 6 , 2006, , Pages 501-505
Abstract
Background and aim: Atopic dermatitis (AD) is a chronic relapsing skin disease that commonly begins during infancy and early childhood. Research studies refers to a relationship between exacerbation of atopic dermatitis and exposure to house dust mite (HDM), but the role of HDM in the pathogenesis of ...
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Background and aim: Atopic dermatitis (AD) is a chronic relapsing skin disease that commonly begins during infancy and early childhood. Research studies refers to a relationship between exacerbation of atopic dermatitis and exposure to house dust mite (HDM), but the role of HDM in the pathogenesis of AD is controversial. The objecitve of this study was to assess the correlation of density of HDM in homes of AD patients with clinical severity of AD and total serum IgE level.Materials and Methods: The severity of AD was determined in 150 patients referred to Hazrat-E-Rasoul hospital dermatology clinic from May 2001 to February 2003 using SCORAD. Total serum IgE level and mite population densities in 5 minutes suction of floors and mattresses at the homes of patients were determined.Results: There was an statistical correlation between relative mite population densities and total serum IgE with SCORAD (P=0.01).Conclusion: Reducing HDM population in homes of AD patient may help a better management of the patients.
SZ Ghodsi; H Ghani Nezhad; L Farpoor; A Ali Mardani; A Taheri; P Mansoori
Volume 8, Issue 2 , 2005, , Pages 115-120
Abstract
Background: Geographic tongue is an inflammatory disorder of unknown etiology that affects the epithelium of the tongue. It has been associated with several cutaneous diseases. Objective: To determine the prevalence of geographic tongue and its association with other cutaneous diseases in patients referred ...
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Background: Geographic tongue is an inflammatory disorder of unknown etiology that affects the epithelium of the tongue. It has been associated with several cutaneous diseases. Objective: To determine the prevalence of geographic tongue and its association with other cutaneous diseases in patients referred to the dermatology clinic of Razi hospital. Patients and methods: A cross-sectional study was performed on all patients referred to one of the dermatology clinics of Razi hospital between February 21 and March 18, 1996 to determine the prevalence of geographic tongue and other diseases. Results: One-thousand and one-hundred and sixty referred patients were studied. The prevalence of geographic tongue was 6.2%. There was a statistically significant association between geographic tongue and seborrheic dermatitis (P=0.0053). Conclusion: Geographic tongue is associated with some cutaneous diseases. Detection of these associations could be a clue to the etiology and pathogenesis of geographic tongue.
Z Pourpak; AR Ranjbar; AH Farhoodi; M Movahedi; A Koohkan
Volume 6, Issue 2 , 2003, , Pages 40-52
Abstract
Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were ...
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Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease with a prevalence of 10-20%. Recent studies suggested the effect of selenium on immunoregulation in AD. In this study we report 4 cases of atopic dermatitis according to Hafniin and Rajka criteria. Serum selenium levels were increased and serum total IgE were decreased in all patients. These results show that selenium is in the cells, therefore selenium could be a suitable and effective treatment. Further studies are required with increased subjects, different dosages and treatment duration to reach more definite results.
H Seyrafi; F Farnaghi; S Fathabadi
Volume 6, Issue 1 , 2002, , Pages 16-20
Abstract
Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response ...
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Background: Due to the chronic nature of atopic dermatitis and dependence of most patients to steroids, finding a suitable alternative treatment is important. Objectives: To determine the efficacy of phototherapy in treatment of atopic dermatitis, also to evaluate possible influencing factors in response of patients to psoralen+UVA (PUVA) therapy. Patients and Methods: 13 patients with resistant atopic dermatitis, older than 10 years, were treated with PUVA, 2 or 3 times a week until complete recovery or maximum of 30 sessions. Rate of recovery was determined according to reduction in 6 signs including itching, erythema, lichenification, xerosis, exfoliation and excoriation at the end of the treatment period and 2 months later. Results: 10 patients (77%) at the end of the treatment and 9 patients (69.2%) two months after that, showed more than 50% recovery. There was no significant relationship between the pretreatment serum IgE levels, site of the lesions, age, sex and phototherapy. The patients with family history of atopic dermatitis showed a better response to the treatment. Conclusion: PUVA is a suitable alternative treatment in resistant cases of atopic dermatitis.
A Athar Moein
Volume 2, Issue 1 , 1998, , Pages 13-16
Abstract
Atopic dermatitis is one of the commonest childhood diseases. Large variations in the prevalence of the disease have been observed in different studies. This variation in the prevalence may be not only from genetic and environmental factors but also from methodology of estimating prevalence of the disease. ...
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Atopic dermatitis is one of the commonest childhood diseases. Large variations in the prevalence of the disease have been observed in different studies. This variation in the prevalence may be not only from genetic and environmental factors but also from methodology of estimating prevalence of the disease. In this study, Hanifin and UKWP criteria have been used in determining prevalence of the atopic dermatitis in school children. Firstly, the educational areas and schools were chosen by the systematic random sample. Then, the disease prevalence of the first and fifth grade students was determined by considering the parental questionnaires and physical examination. The prevalence of AD was 0.8% with Hanifin and 1.5% with UKWP criteria. The overall prevalence of dermatitis was 7.9%. Therefore, the prevalence of AD in a population varies based on the method used. It is very important for a researcher to use the standard methodology where it is possible or define the disease carefully. There is still some needs in determining more sensitive, specific and practical criteria for the diagnosis of AD.