A Asilian; A Momeni; G Faghihi; V Sadeghi; M Sadeghi; H Sadeghi
Volume 6, Issue 2 , 2003, , Pages 30-33
Abstract
Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and ...
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Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by leishmania species. An ideal treatment for CL has not found yet. Objectives: To evaluate the efficacy of cryotherapy alone and combined with intralesional glucantime injection in the treatment of papulonodular CL. Patients and Methods: 300 patients with CL were randomly assigned to two treatment groups in this clinical trial. In group 1, 100 patients with 149 lesions were treated with cryotherapy plus intralesional glucantime injection every 2 weeks. In group 2, 200 patients with 230 lesions were treated only with cryotherapy, every 2 weeks. Both groups were followed for 6 months after last treatment. Results: Clinical and parasitological cure were seen in 90% of cases in group 1 and 57.3% in group 2 (P<0.05). Conclusion: Combination of cryotherapy and intralesional glucantime injection is an effective treatment modality in early lesions of CL.
G Sadeghian; SH Hejazi; M Kalantari
Volume 5, Issue 1 , 2001, , Pages 39-42
Abstract
Background: Cutaneous leishmaniasis is a common parasitic disease in Isfahan province. A common complication of cutaneous leishmaniasis is bacterial superinfection, which may intensify the disease and produce scarring. Objective: The aim of this study was to determine the bacterial species isolated from ...
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Background: Cutaneous leishmaniasis is a common parasitic disease in Isfahan province. A common complication of cutaneous leishmaniasis is bacterial superinfection, which may intensify the disease and produce scarring. Objective: The aim of this study was to determine the bacterial species isolated from infected lesions of cutaneous leishmaniasis. Patients and Methods: Two hundred out of 874 patients with cutaneous leishmaniasis referred to Dermatology and Leishmaniasis Research Center in Amin Hospital in Isfahan during four months (September to December 1999) who had signs of bacterial superinfection were studied by taking microbial cultures from their lesions. Results: Bacterial cultures were positive in 177 cases (20.7% of all patients and 88.5% of sample patients). The isolated bacterias included S.aureus in 61.5%, S.epidermidis in 20.5%, E.coli in 3.5%, proteus vulgaris in 1.5% and Klebsiella in 1.5%. Eighty seven percent of infected patients had ulcerative nodules. Bacterial super infection was significantly more common in ulcerated lesions than non-ulcerated ones (P=0.00001).
F Iraji; R Tavakoli
Volume 4, Issue 4 , 2001, , Pages 3-7
Abstract
Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess ...
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Background: Evaluation of the impacts cutaneous of leishmaniasis (CL) on the patients, their family and government are necessary. Unfortunately these evaluations have not been done. Objective: Due to increased incidence of CL in Isfahan province especially in rural areas, this study was done to assess the expenses of this disease in Isfahan in 1999. Patients and Methods: 196 patients were selected randomly from four areas of Isfahan province (2 rural and 2 urban), on the basis of data from Health Center in 1999. The amount of money that was paid for physician visit, traveling, accessory expenses (For example to buy insecticide), injections, dressing and drugs for treatment of CL were asked and recorded. Results: The mean amount paid in rural and urban areas were 208307 and 457327 Rials, respectively. Conclusion: Incidence of CL is about 10-30 thousands of patients in Isfahan each year, therefore the yearly expense of treatment is about 3-6 milliard Rials. We must change our strategies for controlling and eradicating this problem.
AR Gholami; A Khamesipour; A Momeni; T Ghazanfari; MA Nilforoush Zadeh; Z Darajeh; Y Dowlati
Volume 3, Issue 3 , 2000, , Pages 2-6
Abstract
Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. ...
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Background: Cutaneous leishmaniasis (CL) is a protozoan disease of the skin caused by a wide range of italic species. The disease is endemic in many countries. It has been recognized as a major public health problem in Iran. Many treatments have been suggested for it but none of them was fully effective. Objective: The objective of this study was to compare the efficacy of a 5% garlic cream with placebo in CL. Patients and Methods: A double blind, placebo controlled study was performed in Isfahan and Jahrom in 1997 and 1998. 197 patients were randomly selected. Exclusion criteria were: pregnancy, lactation, age less than 5 years and duration of disease more than 100 days. Each patient received garlic cream 5% or placebo for 3 weeks and was followed for another period of 40 days. Results: The study was completed as planned in 171 patients. 96 were treated with garlic 5% cream and 75 with placebo. Complete healing occurred in 18 (18.75%) of garlic group in comparison with 15 (20%) of placebo group. The difference was not significant (P=0.9865). Conclusion: 5% garlic cream was not effective in treatment of cutaneous leishmaniasis. Further studies with higher concentrations or different vehicle are needed.
A Kiani; F Iraji; F Shariati
Volume 3, Issue 2 , 2000, , Pages 39-42
Abstract
Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between ...
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Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between antimony compounds and cyclosporine metabolites. We report a 45-year old man with 5 years history of kidney transplantation receiving immunosuppressive drugs who had an extensive, painful ulcer on the left and upper side of his chest. Laboratory evaluation confirmed the diagnosis of cutaneous leishmaniasis. The patient was treated successfully with a 3-week period of intramuscular Glucantime.
Sh Enshaieh; A Kiani
Volume 3, Issue 1 , 1999, , Pages 11-15
Abstract
Background: Cutaneous Leishmaniasis is one of the most common parasitic diseases in Isfahan, the scar of it could be found in the majority of residents of some areas of city. This disease can affect all age groups but it is more common in children in endemic and hyperendemic areas. Objective: The purpose ...
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Background: Cutaneous Leishmaniasis is one of the most common parasitic diseases in Isfahan, the scar of it could be found in the majority of residents of some areas of city. This disease can affect all age groups but it is more common in children in endemic and hyperendemic areas. Objective: The purpose of this study was to evaluate clinical features of cutaneous leishmaniasis in children less than 12 years old in Isfahan. Patients and Methods: We studied 656 cases younger than 12 years among 2000 patients referred to “Center of Leishmaniasis” in Isfahan, from October 96 to October 97. The diagnosis of cutaneous leishmaniasis was confirmed by direct smear in all cases. Results: Among 2000 patients, 656 cases (32.8%) were less than 12 years old, 53.4% of them were male and 46.6% were female. Most of the lesions were papules (28.4%), and the most common site of involvement was face (38.6%). The number of lesions ranged from 1 to 20, but most of the patients had only one lesion (46.3%).
A Momeni; A Khamesipour; A Bagher Zadeh; M Amin Javaheri
Volume 3, Issue 1 , 1999, , Pages 24-30
Abstract
Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran ...
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Background: Cell-mediated immunity (CMI) plays an important role in resistance against leishmaniasis. Leishmanin test (Montenegro skin test) is a method in evaluation of immune system reaction against cutaneous leishmaniasis. The TDR/WHO reference Leishmanin produced by the Pasteur Institute of Iran is used worldwide. Two other antigens produced by Razi Serum Institute of Iran, Killed Leishmania Major (K.L.M) and Autoclaved Leishmania Major (A.L.M), take advantage of vaccine strains of L.major, and under supervision of WHO, have been investigated as leishmaniasis vaccine. Objective: KLM, ALM and standard Leishmanin as skin test wee compared in this study. Patients and Methods: Fifty patients with cutaneous leishmaniasis were randomly selected. They attended the educational clinics of Isfahan University of Medical Sciences. All 3 antigens were injected intradermally in them and the size of erythema and induration were read and recorded after 48 hours. Data were grouped and analyzed with analysis of variance (ANOVA). Results: There was significant difference between mean of erythema and induration sizes of antigens in two by two comparison. The mean of erythema and induration sizes due to K.L.M were greater than A.L.M, and mean of erythema and induration sizes due to A.L.M were greater than Pasteur Institute reference leishmanin (P<0.0001). Conclusion: Although the mean of erythema and induration sizes due to K.L.M were greater than others, use of A.L.M seems to be more practical compared to. K.L.M, because of simple storage method of A.L.M, and more sensitive than Pasteur Institute reference leishmanin.
R Yaghoobi; N Hoghooghi Rad
Volume 1, Issue 1 , 1997, , Pages 19-23
Abstract
Cutaneous leishmaniasis is a parasitic infection prevalent in many areas. The parasitic agent is usually transmitted by Phlebotomous sp. Lip leishmaniasis is a type of cutaneous leishmaniasis, which has rarely been reported. In a retrospective study performed in Ahwaz, center of Khuzestan province, southwest ...
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Cutaneous leishmaniasis is a parasitic infection prevalent in many areas. The parasitic agent is usually transmitted by Phlebotomous sp. Lip leishmaniasis is a type of cutaneous leishmaniasis, which has rarely been reported. In a retrospective study performed in Ahwaz, center of Khuzestan province, southwest of Iran, 2861 patients were detected during 1986-1996. Seventeen of these patients (0.59%) had lower or upper lip leishmaniasis. The patients, age ranged from 3 months to 40 years. Duration of infection was 2 to 4 months. Eleven patients had only lip lesions whereas 6 patients had one or more skin lesions elsewhere. The appearance of lesions differed from nodules to crusted ulcers, usually observed on the vermilion border. Most of the cases failed to respond to topical or systemic antibiotic therapy. The diagnosis was based on the demonstration of Leishman bodies in Giemsa stained smears.