Anvari Kazem; Hosseini Sare; Toussi Mehdi Seilanian; Afifi Saeede
Volume 17, Issue 1 , 2014, , Pages 27-30
Abstract
Background: Non melanoma skin cancer (NMSC) is the most common cancer worldwide. In most cases, the general outlook is excellent; however, local recurrence or metastasis can occur. In this study, we investigated possible tumor and host characteristics affecting the treatment outcome in our department ...
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Background: Non melanoma skin cancer (NMSC) is the most common cancer worldwide. In most cases, the general outlook is excellent; however, local recurrence or metastasis can occur. In this study, we investigated possible tumor and host characteristics affecting the treatment outcome in our department of radiation oncology.Method: We retrospectively studied cases with non melanoma skin cancer (NMSC) who were consecutively referred to department of radiation oncology in Omid and Ghaem Hospitals between 1997 and 2007. The effect of the patients’ characteristics (age, sex), tumor characteristics (histology, size, location), and treatment modalities on prognosis were evaluated.Result: We studies 426 patients with a median age of 65 (range: 14 to 102) and a male to female ratio of 1.4:1. Pathologic review showed 72% of the patients had basal cell carcinoma (BCC) and 28% had squamous cell carcinoma (SCC) with a 5-year event free survival of 87±3% and 67±8%, respectively (p < 0.001). The local recurrence rate was higher in cases with scalp lesions (35%). The patients who underwent combined modality treatment experienced significantly more instances of failure as compared to those receiving radiotherapy alone (5-year event free survival of 81±6% vs. 84±6%, p=0.04) which reflects the higher number of cases with adverse features including larger lesions and/or a positive surgical margin in this group. Sex, age, and multifocality were not significant predictors of prognosis.Conclusion: SCC histology and scalp location were predictive of higher rates of treatment failure in patients with NMSC. There was no correlation between age, sex, multifocality and overall outcome. The higher rate of recurrence in cases receiving combined modality treatment is most probably due to the high number of tumors with adverse prognostic features in these cases.
Maryam Akhyani; Hasan Seirafi; Zahra Hallaji; Pardis Kiani; Sara Sabouri rad; Hosein Ahrar Mohammad
Volume 14, Issue 1 , 2011, , Pages 6-11
Abstract
Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of ...
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Background: Alopecia Areata (AA) is a recurrent non-scarring type of hair loss that can affect any hair-bearing area. Prognosis of AA is unpredictable and most patients experience more than one episode of hair loss. The purpose of this study was to investigate the relationship between the severity of AA with respect to age of onset, nail involvement, family history, number of recurrences and duration of the disease. Methods: A total of 239 consecutive patients with AA who were visited in our dermatology clinic from June 2009 to November 2009 were included in this study. The extent of scalp involvement, age of onset, nail involvement, family history, number of recurrences and duration of AA were recorded. Results: Two hundred and thirty nine (239) patients with AA including 141 males and 98 females entered our analysis (male: female ratio = 1.43:1). The age of the patients at the onset of the disease had a wide range from 1 to 60 years (mean ± SD = 21.51 ± 5.4). Two hundred and twelve patients (88.7%) had their first episode of AA before the age of 40 years. Duration of the AA varied from 1 month to 31 years. Ninety six (40.2%) patients experienced only one episode and 25 patients (10.5%) had more than 4 episode of alopecia. Nail changes was reported in 34 patients (14.2%). Forty five patients (18.8%) had a positive family history of alopecia areata. A personal history of atopy and autoimmune diseases was seen in 23 (9.6%) and 27 (11.3%) patients, respectively. The relationship between extensive AA and age of onset, duration, nail changes and positive family history was confirmed (p 0.05). Conclusion: AA occurred at a comparatively younger age. There was a correlation between extensive alopecia areata and age of onset, duration, nail changes, and positive family history as prognostic factors. There were no relationships between the severity of AA and sex, history of atopy and autoimmune diseases.