Juan Raul Castro-Ayarza; Luisa Fernanda Montenegro
Abstract
Background: Basal cell carcinoma (BCC) represents nearly 80% ofcutaneous malignancies. Dermoscopy is a useful tool to increasethe precision of diagnosis, but its findings for BCC are mainlydescribed in patients from Europe, the US, and Australia. BCCdermoscopy patterns are not fully known in patients ...
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Background: Basal cell carcinoma (BCC) represents nearly 80% ofcutaneous malignancies. Dermoscopy is a useful tool to increasethe precision of diagnosis, but its findings for BCC are mainlydescribed in patients from Europe, the US, and Australia. BCCdermoscopy patterns are not fully known in patients with skinphoto-types III and IV in Latin America, especially in Colombia.We aimed to describe dermoscopy findings in patients with BCCand III-IV Fitzpatrick skin types in a Colombian population.Methods: A descriptive, retrospective and prospectiveobservational study was carried out on patients with BCC.Clinical and dermoscopy photos were taken, with the diagnosisconfirmed via histopathology.Results: Thirty-six tumors were evaluated. Women were moreaffected. The main BCC feature was a nodular clinical andhistological subtype. The more frequent dermoscopy findingswere arboriform microvessels, thin telangiectasias, and multiplegray-blue globules. Tumors greater than 6 mm predominantlyshowed ulceration and polymorphic vessels. The presence ofovoid nests, structures in maple leaves, and polymorphic vesselswere related to the superficial clinical subtype.Conclusions: Different features related to size, clinical pattern, andthe presence of vascular and pigmentary changes in dermoscopywere present in this population. A new dermoscopy finding ofa yellowish type “amber background” in BCC was described.
Maryam Khalili; Simin Shamsi Meymandi; Mahin Aflatoonian; Ali Bagheri
Abstract
Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, ...
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Background: Basal cell carcinoma is the most common skin cancer, constituting nearly 80% of non-melanoma skin cancers. In this study, for the first time in Kerman, the clinicopathological features of basal cell carcinoma in patients referred to Afzalipour Hospital were evaluated.Methods: This is a retrospective, cross-sectional study on 145 skin biopsy samples with a diagnosis of basal cell carcinoma in Afzalipour Hospital, Kerman. Demographic features of patients and clinical and pathologic types of basal cell carcinoma were recorded. Then, the correlation between clinical or histological types with demographic features was evaluated using the chi-squared test.Results: Ninety-four (64.8%) of the cases were male, and the mean age of the patients was 68.12 ± 14.54 (min = 15, max = 101) years. The most and the least common sites of involvement were the nose (35.9%) and trunk (0.7%), respectively. The most common clinical (76.5%) and pathological subtypes (71.03%) were nodular. The least common clinical (6.3%) and pathological types (2.1%) were morpheaform. There was no significant correlation between histopathological or clinical types with demographic features including age and sex. Furthermore, there was no significant correlation between sex and the site of the involvement or age of the patients.Conclusion: In this study, most patients were between 60-79 years of age, and the male-to-female ratio was 1.8 to 1. Nodular and morpheaform types were the most and the least common pathological and clinical types, respectively.
Maryam Nasimi; Robabeh Abedini; Zahra Halaji; Maryam Hosseinizadeh; Fariba Mohammadi
Abstract
Background: Basal cell carcinoma (BCC) is the most common form of malignancy in white populations. It has been hypothesized that dietary factors may play a role in BCC development. In this study, serum levels of folic acid and vitamin B12 were evaluated in patients with BCC to investigate the potential ...
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Background: Basal cell carcinoma (BCC) is the most common form of malignancy in white populations. It has been hypothesized that dietary factors may play a role in BCC development. In this study, serum levels of folic acid and vitamin B12 were evaluated in patients with BCC to investigate the potential role of these vitamins in BCC development.Methods: Forty-five BCC patients and 45 age- and sex-matched healthy controls were enrolled in the study. Patients with a history of radiotherapy in the affected area were excluded. All participants completed a questionnaire including demographic characteristics, and blood samples were taken to evaluate serum levels of folic acid and vitamin B12.Results: There were no significant differences in serum levels of vitamin B12 and folic acid between healthy controls and BCC patients. Serum levels of vitamin B12 were significantly higher in female patients than male patients.Conclusion: It seems that BCC is not related to serum levels of vitamin B12 and folic acid; however, this issue should be studied with larger sample sizes.
Yalda Nahidi; Naser Tayyebi Meibodi; Habiballah Esmaeili; Zahra Tafazzoli
Abstract
Background: Basal cell carcinoma (BCC) is the most common type of skin tumor. Surgical removal has remained the gold standard of treatment for BCC, but incomplete removal is an important clinical challenge. The goal of our study was to evaluate the incomplete excision of BCC and the factors affecting ...
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Background: Basal cell carcinoma (BCC) is the most common type of skin tumor. Surgical removal has remained the gold standard of treatment for BCC, but incomplete removal is an important clinical challenge. The goal of our study was to evaluate the incomplete excision of BCC and the factors affecting it.
Methods: In this retrospective study, 361 histological samples of BCC excisions referred to the Pathology Department of Imam Reza Hospital, Mashhad, Iran, from 2004 to 2018 were reviewed. Data including age, gender, tumor site, size, histopathologic subtype, surgical margin involvement, and the surgeon’s specialty were recorded.
Results: The incomplete removal rate was 20%. Ten percent of the lesions had deep margin involvement, 5.8% had lateral margin involvement, and both margins were involved in 4.2% of cases. Incomplete excision had a significant relationship with the following variables: nodular, mixed, and sclerosing types; the 60-70 years age group; lesions larger than 2 cm, location in nose and canthi; and excision by an otorhinolaryngologist, ophthalmologist, or dermatologist.
Conclusion: In this study, the frequency of incomplete excision was relatively high compared with other studies. Therefore, it is suggested to perform a diagnostic biopsy before the complete excision of BCC. Excision with a wider margin or using Mohs surgery is recommended for midface lesions, older individuals, nodular, mixed, or sclerosing lesions, and for tumors larger than 2 cm.
Leila I Izadi Firouzabadi; Hamidreza Mahmoudi; Ali Khamesipour; Abhay Satoskar; Alireza Firooz
Abstract
Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: ...
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Background: Basal cell carcinoma (BCC) is the most common type of skin malignancy. Hyperthermia is used as adjuvant therapy together with radiotherapy and chemotherapy in the treatment of some cancers. This study aimed to evaluate the efficacy and safety of thermotherapy in the treatment of BCCs.
Methods: This pilot trial was carried out on five patients with nodular or superficial BCCs on the scalp and face.Thermotherapy was done at 50° C for a duration of 30 seconds with a radiofrequency device (Thermomed 1.8 thermosurgery technologies). Thermotherapy treatment was applied only in one session. The first follow-up was one week after the procedure and then every month for six months. The last follow-up was one year after the procedure.
Results: All patients showed clearance of the tumors. Blisters, ulcers, crusts, and necrosis were the side effects, which healed with acceptable degrees of scarring. No recurrence was observed at the end of the study.
Conclusion: Thermotherapy was safe and efficacious for the treatment of BCCs on the scalp and face. It should be considered especially for the low-risk subtypes of this cancer.
Neda Hosseini Sarani; Mehran Ataei; Tannaz Akbari Kolagar; Elaheh Heydari; Maryam Farzaneh; Amir Anbiyaiee
Abstract
Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. ...
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Skin cancer is the out-of-control growth of skin cells that can be divided into keratinocyte carcinoma (non-melanoma) and malignant melanoma. Basal cell carcinoma (BCC) and squamous cell carcinomas (SCC) are the most common forms of keratinocyte carcinoma that may grow to involve other parts of the body. These cancers are caused by exposure to ultraviolet (UV) light, toxic substances, and a family history of skin problems. Different signaling pathways are likely to be involved in skin cancer. The TP53 gene (the gene coding for cellular tumor protein p53) is among the most diverse and complex molecules involved in cellular functions. The p53 pathway can initiate DNA replication, modulate cell cycle events, and interact with tumor suppressor genes (TSGs). Mutations in TP53 can occur in numerous human cancers, leading to cellular immortalization, inappropriate proliferation, and genomic instability. TP53 plays a big role in both melanoma and non-melanoma skin cancers. Despite the intensive investigation to clarify the impact of TP53 mutations in the induction of skin cancer, much remains to be elucidated. In this mini-review, we will discuss the protective role of p53 as a bona fide tumor suppressor gene in human skin cancers.
Mina Almasi-Nasrabadi; Reza M Robati
Abstract
Basal cell carcinoma (BCC) is the most common form of nonmelanoma skin cancer. A review of the literature revealed only a few reports of BCC on the auricle or conchal bowl, usually occurring in elderly patients. Herein, we report an exceptional case of BCC in a young man with an unusual anatomical location ...
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Basal cell carcinoma (BCC) is the most common form of nonmelanoma skin cancer. A review of the literature revealed only a few reports of BCC on the auricle or conchal bowl, usually occurring in elderly patients. Herein, we report an exceptional case of BCC in a young man with an unusual anatomical location of the tumor as a solitary erythematous to black-colored plaque located in the conchal bowl of his right ear. By thoroughly reviewing the literature, there was no other documented case of BCC located in the conchal bowl of the ear of a young adult. Dermatologists should be aware that skin tumors may also occur in uncommon anatomical locations and with unusual presentations in the young population, even if they have no known predisposing factor. Unusual presentations make clinical suspicion of skin tumors very difficult, so these lesions can easily be missed. Early diagnosis can prevent further growth, extensive destruction, and severe consequence of invasive treatments.
Yalda Nahidi; Naser Tayyebi Meibodi; Amir Hossein Jafarian; Habibollah Esmaily; Elham Pishnamaz
Abstract
Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering ...
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Background: Radiation-induced basal cell carcinoma (BCC) can be multiple, large, and recurring, which complicates its treatment in some cases. According to reports on the role of cyclooxygenase 2 (COX2) inhibitors in the treatment or prevention of non-melanoma skin cancers and considering the fact that COX2 expression has not been evaluated in radiation-induced basal cell carcinoma, weset out to assess the expression of COX2 in these lesions. Methods: In this study, COX2 expression was assessed by immunohistochemistry using anti-COX2 antibody on paraffinembedded blocks of 86 patients referred to Emam Reza Hospitalin Mashhad with BCC diagnosis by pathological examination (43 patients with and 43 without a history of radiotherapy) followed by semi-quantitative evaluation of COX2. Results: In our study, COX2 expression score was significantly higher in patients with a history of radiotherapy than those without radiotherapy (P<0.001). No correlation was found between theintensity and percentage of staining with sex, age, site of lesion, recurrence, and pathology of the tumor. Conclusion: Given the higher expression level of COX2 in the radiation-induced BCC patients, the use of COX2 inhibitors in these individuals may be effective in the incidence, recurrence, or treatment of BCC.
Ehsani Amir Hooshang; Noormohammadpoor Pedram; Sadeghinia Ali; Hemmati Sara; Ahmadi Maedeh; Sotoudeh Sara; Azizpour Arghavan; Nasimi Maryam
Volume 20, Issue 4 , 2017, , Pages 118-121
Abstract
Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional ...
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Background: Basal cell carcinoma (BCC), the most common form of skin cancer, usually occurs in the sun-exposed areas of the body like head and neck, yet is also seen in unexpected sites. Myriad studies have mentioned a lower limb BCC incidence rate of 1.5-13.5%.Methods: The present retrospective cross-sectional study was conducted on 650 BCC patients, who were referred to the dermatology tumor clinic of Razi hospital from 2008 to 2012 with confirmed biopsy results of BCC. Patient characteristics including age, sex, relevant history and physical examination and tumor characteristics such as location and pathological subtypes were recorded.Results: The prevalence of lower limb BCC was 1.53% with the mean age of 69.5 years and a male to female ratio of 2.33:1. Of 10 cases with BCC on the lower extremities, 6 were on the legs, 3 on the thighs and 1 on the foot. The most frequent pathological type was nodular and constant UV exposure was the most important risk factor (60%). Other underlying factors were chemical exposure, chronic ulcer and history of radiation.Conclusion: BCC of the lower limbs is more prevalent in men compared with women. Moreover, UV exposure is the most important risk factor for BCC. On the other hand, factors like ulcers, radiation and chemical exposure have to be further considered.
Ghafoor Rabia; Anwar Muhammad Irfan; Tahir Moizza
Volume 18, Issue 1 , 2015, , Pages 29-32
Abstract
Bazex-Dupre-Christol (BDC) syndrome is clinically characterizedby multiple basal cell carcinomas of the face that mainly occurduring the second and third decade of life, follicular atrophodermapredominantly of the dorsum sides of the hands and feetand generalized hypotrichosis; sometimes with pili torti ...
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Bazex-Dupre-Christol (BDC) syndrome is clinically characterizedby multiple basal cell carcinomas of the face that mainly occurduring the second and third decade of life, follicular atrophodermapredominantly of the dorsum sides of the hands and feetand generalized hypotrichosis; sometimes with pili torti andtrichorrhexis nodosa. Features commonly associated with BDCare milia, hypohidrosis and calcifying epithelial tumours. In thisstudy, four members of one family with BDC syndrome, a motherand her three daughters were reported. The major clinical featuresof BDC were very typical in the mother and one of the daughterswhereas only follicular atrophoderma, milia and hypotrichosiswere present in the other two daughters. Bazex Dupre ChristolSyndrome is a hereditary multiple basal cell carcinoma (BCC)syndrome whose pattern of inheritance is thought to be X-linkeddominant, which implies that all daughters of affected mothersshould be having this disease. In this case report, among the fourdaughters, only three were suffering from BDCS while one istotally asymptomatic. Based on the literature review, this appearsto be the first report of a family with BDC from Pakistan.
Maleki Masoud; Naghibi Masih; Sabouri-Rad Sara; Sardar Akram
Volume 17, Issue 1 , 2014, , Pages 18-21
Abstract
Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, ...
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Background: The higher frequency of malignant skin tumors is of great significance in renal transplant recipients (RTRs) who should receive immunosuppressive therapy for a long time. This study was designed to determine the frequency of malignant skin tumors in RTRs in Imam Reza Hospital, Mashhad, Iran, in 2001-2002.Method: This descriptive study was performed on 322 recipients who were examined by a dermatologist for malignant skin tumors in the renal transplant unit. A questionnaire containing a detailed history of age, sex, and site of the lesion, time of transplantation, occupation, and time of cancer development was completed for patients with a biopsy proven skin cancer.Result: Nine patients (2.8%) had malignant skin tumors. Five patients (55.55%) had Kaposi sarcoma (KS) and 4 patients (44.44%) had non melanoma skin cancer (NMSC). The mean age of the patients was 44.4 ±11.4 years. Eight patients (88.88%) were male. The mean time to development of Kaposi sarcoma and NMSC development was 9.1 months and 5.75 years, respectively. Three patients (60%) with Kaposi sarcoma had lesions on lower extremities and all the NMSCs were located in the head and neck region. Outdoor occupations were seen in at least 50% of NMSCs.Conclusion: This study again showed the importance of regular dermatologic examination for early diagnosis of skin malignancies, particularly, in high risk groups including renal transplant recipients.
Dehghani Leila; Khanjani Narges; Bahrampour Abbas
Volume 15, Issue 4 , 2012, , Pages 111-116
Abstract
Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof ...
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Background: Skin cancers are the most common human cancers.The most common skin cancers are basal cell carcinoma, squamouscell carcinoma and malignant melanoma. Different factors areinvolved in development of skin cancers; the most notable oneis exposure to ultraviolet radiation. In this study, the incidenceof skin cancer was determined in Kerman province where islocated in the desert region of Iran with ample sunlight, duringa 5–year period.Method: All registered cases of skin cancers between March2005 and March 2010 were retrieved from the Kerman ProvinceCancer Registry. For each patient, data about age, gender,location, pathologic type of cancer and site of skin involvement,were obtained. Incidence rates according to the age, sex and thelocation of the lesions were calculated. Trend analysis was donefor the next 10 years.Result: During these 5 years, 1250 cases of skin cancer wererecorded. The incidence in men was 1.2 times higher than women.The highest incidence was seen in individulas older than 80 yearsof age. Fifty percent of all skin cancers were located on the face.The highest incidence was observed in the city of Kerman withan annual incidence of 12.6 in 100,000. Trend analysis showedthat the incidence of skin cancer in Kerman province would reach23 in 100 000 people in 2019, which is 2.3 times higher than theincidence rate in 2009.Conclusion: Skin cancer is a public health concern in Kermanprovince in Iran. Considering the desert climate and the intensity ofsunlight in most seasons, it is necessary to plan scientific practicalinterventions to prevent skin cancer and reduce its incidence..
Mostafa Mirshams Shahshahani; Mahmood Razzaghi; Amir Houshang Ehsani; Pedram Normohamadpour; Zahra Naraghi; Kambiz Kamyab; Sara Sabouri Rad
Volume 14, Issue 1 , 2011, , Pages 1-5
Abstract
Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell ...
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Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 patients) lesions which were excised in Razi Dermatology Hospital of Tehran from 2006 to 2008 were evaluated in this case series and their findings were analyzed with SPSS software. Results: Incidence of incomplete excision was 12% and involvement of the deep margin was observed in 54% of these lesions. Factors related to incomplete excision were infiltrative, morpheic and micronodular subtypes, lesions larger than 20 mm, those repaired by skin grafts and those that received local anesthesia. There was no statistically significant difference in age, sex, site of lesions and childhood history of radiotherapy for tinea capitis. Conclusion: Recognizing the risk factors related to incomplete excision of BCCs would help us consider a wider excision margin for high risk tumors.
Hamideh Moravej Farshi; Hakimeh Zali; Mostafa Rezaei-Tavirani; Parviz Toossi
Volume 13, Issue 4 , 2010, , Pages 112-117
Abstract
Background: Basal Cell Carcinoma (BCC) is a type of non-melanoma skin cancer. Alteration in gene expression is the important event that happens in cancer cell. Detection of this event is possible by proteomics techniques. Methods: Normal and tumor tissues were taken from BCC patient. Total proteins were ...
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Background: Basal Cell Carcinoma (BCC) is a type of non-melanoma skin cancer. Alteration in gene expression is the important event that happens in cancer cell. Detection of this event is possible by proteomics techniques. Methods: Normal and tumor tissues were taken from BCC patient. Total proteins were purified by standard methods, and proteins were separated by two-dimensional electrophoresis (2DE). Mass spectrometry (MS-MALDI method) was used as a powerful instrument for protein identification. Results: Eighty seven spots of protein were detected in 2DE gels out of which, 76 spots had different expression in normal and cancer gel images. Comparison with the data base showed 11 proteins. Nine spots had no association with BCC, but expression of ceruloplasmin and C3b were decreased and increased respectively in cancer tissues, compared to normal cell. The mass spectrometry results were aldolase C, Prx-cis and VDAC. Conclusion: These recognized proteins, either with increased or decreased expression in cancer tissue, might be considered as new biomarkers in BCC patients.
Tehranchinia Zohreh; Rahimi Hoda; Shahidi-Dadras Mohammad; Farnaghi Ali; Ahadi Mahsa Seyed; Ahadi Maral Seyed
Volume 13, Issue 3 , 2010, , Pages 71-77
Abstract
Background: Basal Cell Carcinoma (BCC) is the most common type of skin cancer in human beings. Photodynamic therapy (PDT) is a novel therapeutic method which may be regarded as a non-invasive useful alternative for traditional treatments of BCC. This study was designed with the aim of evaluating the ...
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Background: Basal Cell Carcinoma (BCC) is the most common type of skin cancer in human beings. Photodynamic therapy (PDT) is a novel therapeutic method which may be regarded as a non-invasive useful alternative for traditional treatments of BCC. This study was designed with the aim of evaluating the primary response of BCC to PDT.Methods: This clinical trial was performed on 28 BCC lesions. Patients were treated with ALA-PDT monthly for 1-6 sessions and evaluated for clinical response, cosmetic results and probable side effects.Results: Twenty three out of 28 lesions showed response to PDT (9 showed complete response and 14 showed partial response). The cosmetic result was excellent or good in 77.5% of the cases. In 92.8% of the cases, no or mild side effects were observed. Patients with a positive history of radiotherapy responded less (p<0.05). No significant relationship was found between patients' age, sex, localization, diameter or type of BCC with clinical response.Conclusion: PDT might be a good therapeutic option in the treatment of BCC, especially the superficial type, with high efficacy and few side effects.
Shahshahani Mostafa Mirshams; Esmaily Nafiseh; Hallaji Zahra; Kamyab Kambiz; Kalaghchi Bita; Maghsoudnia Gholamreza; Kashani Mansour Nasiri; Narraghi Zahra; Razzaghi Mahmoud; Noormohammadpour Pedram
Volume 11, Issue 2 , 2008, , Pages 73-75
Abstract
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients ...
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Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. UV light is an important risk factor for BCC, as well as X-ray and other ionizing radiations. The aim of this study was evaluation and risk factor assessment of BCC cases referred to Razi hospital tumor clinic. Methods: Patients referred from general clinics with skin biopsies consistent with Basal Cell Carcinoma were enrolled. A questionnaire including epidemiologic data, risk factor exposure and specification of skin lesions was completed for each patient. Results: From October 2005 to October 2006, a total of 476 patients with cutaneous malignancy referred to Tumor clinic of Razi hospital. Of them, 367 patients had BCC. 215 were male (58%) and 152 were female (42%). Mean age of patients was 62 (±12.7) and 62 (±13.4) years for men and women, respectively. The most common risk factors for BCC were radiotherapy and chronic sun exposure. The most common tumor sites were scalp, nose and ears. Of different clinico-pathologic types, noduloulcerative type was the most common. Conclusion: It seems that radiotherapy is an important risk factor in Iranian BCC patients and it is useful to have a screening program for case finding and treating patients in early stages.
Meybodi Naser Tayebi; Javidi Zari; Memar Bahram; Farhadi Farzaneh; Nahidi Yalda
Volume 10, Issue 3 , 2007, , Pages 203-210
Abstract
Background and aim: Basal cell carcinoma (BCC) is the most common skin cancer in white-skin populations. Recent studies suggest that BCC is not a single entity and different histological subtypes show different clinical behavior and might have different etiology. The aim of this study was to assess differences ...
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Background and aim: Basal cell carcinoma (BCC) is the most common skin cancer in white-skin populations. Recent studies suggest that BCC is not a single entity and different histological subtypes show different clinical behavior and might have different etiology. The aim of this study was to assess differences in age, sex, site of distribution and proliferative activity in histological subtypes of BCC. In addition association of BCC with solar keratoses is assessed.Materials and methods: We studied 299 cases of BCC from the archives of department of pathology, Mashad University of Medical Sciences in a three-year period. Clinical data were recorded and histological slides were rewiewed to confirm the diagnosis and histological subtypes. Results: We recorded 345 BCC in 299 patients with mean age of 59.2 years. 70.8% of patients were male and 29.2% were female. Ninety-four percent of lesions were located in head and neck. Solid pattern of BCC was the most frequent subtype. In superficial and micronodular subtypes, patients were younger and the oldest patients had basosquamous BCC. Adenoid BCC had the most mitotic activity. In 22.2% of cases association with solar keratoses were observed.Conclusion: This study showed difference in age, sex, site of tumor, and proliferative activity in various histological subtypes of BCC that might represent different etiologic factors in different subtypes.
Ansarin Habib; Firoozeh Mahshid; Sadeghipour Alireza; Tajziehchi Leila
Volume 10, Issue 3 , 2007, , Pages 211-218
Abstract
Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed ...
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Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1. Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sex or history of radiotherapy in our patients.Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis.
Naser Tayebi-Meybodi; Zari Javidi; Habib-Allah Esmaili; Yalda Nahidi
Volume 10, Issue 2 , 2007, , Pages 135-141
Abstract
Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible ...
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Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological parameters including the patient's age, sex, subtype of BCC and severity of peritumoral inflammation.Materials and methods: In this retrospective study, a total of 50 BCC specimens either biopsied or excised were examined histologically. H & E stained slides were examined under light microscopy and the severity of inflammation was assessed subjectively and graded as mild, moderate or severe. Then biopsy specimens were stained with Giesma to identify mast cells. Clinical data including sex and age were obtained form patients records. Finally the data were analysed by t test, Mann-Whitney and ANOVA by SPSS software and pConclusion: Our results support previous reports indicating that mast cells may have a contributory role in defining the subtype of BCC and degree of its aggressiveness. It seems that mast cells have a preventive role against aggression of BCC, as we found more mast cells in superficial BCC than deep ones.
M Barzegari; Z Safaei Naraghi; M Akhyani; AH Ehsani; R Mahmoud Robati; S Bagheri Nejad
Volume 9, Issue 2 , 2006, , Pages 159-164
Abstract
Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency ...
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Background and aim:Basal cell carcinoma (BCC) is the most common cancer in whites. The most important risk factor for developing BCC is solar ultraviolet (UV) irradiation. As the weather in most parts of Iran is mostly sunny, BCC is common. This study was performed to evaluate changes in the frequency of BCC in 1368-69 and 1378-79.Materials and Methods: This descriptive and retrospective study was performed as an existing data study and all files in department of pathology in Razi Hospital from 1368-69 and 1378-79 were assessed with regards of BCC frequency, patient age and gender as well as history of radiation and the collected data were compared.Results: A total of 1503 BCCs were studied, 507 were from 1368-69 and 996 from 1378-79 period. In the years 1368-69, relative frequency of BCC was 11.1%. On the other hand in years 1378-79 relative frequency of BCC was increased to 15.2%, which was not associated with gender. BCC occurance showed a significant decrease in 20-30-year age group and a significant increase in over 60 years age group. Among histologic subtypes, nodular form showed an increase, which was statistically significant on face region (P<0.005), but was not linked to patient gender. In male patients significant decrease of BCC frequency on face and increase on head and neck areas was observed, but there was not any significant change in tumor location in female patients.Conclusion:During a 10-year period the frequency of BCC has increased significantly requiring more attention to develop educational programs regarding prevention, diagnosis and early treatment.
N Motamed; B Pour Dadash
Volume 8, Issue 5 , 2005, , Pages 408-418
Z Nilforooshan; A Asilian; MA Nilforoosh Zadeh
Volume 8, suppl , 2004, , Pages 11-16
Abstract
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon ...
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Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent skin cancers. The etiology of these tumors is multifactorial: Environmental and exogenous factors, genotype and phenotype factors. The development of malignant neoplasms at sites of previous dermal scars is an uncommon but well recognized phenomenon, and since almost all of them were developed on exposed areas it has been hypothesized that the accompanying atrophy and decreased vascularity and adnexal structures in areas of scarring may render the affected tissues more susceptible to the effects of environmental factors, eg. ultraviolet light. We report four cases of BCC and SCC on old leishmania scars on face, and recommend that any changes on scars must be evaluated clinically and pathologically.
A Zamanian; M Pilehvar; AR Monsef
Volume 7, Issue 3 , 2004, , Pages 140-144
Abstract
Background: Basal cell carcinoma (BCC) is the most common skin cancer in whites. Objective: Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. Patients and methods: This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients ...
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Background: Basal cell carcinoma (BCC) is the most common skin cancer in whites. Objective: Determination of anatomical localization of BCC in relation to histological subtypes of this tumor. Patients and methods: This survey is a descriptive cross sectional study carried out on 189 cases of BCC patients diagnosed in Hamadan Sina hospital between 1997-1999. Results: This study showed 7 histologic subtypes of BCC. Nodular type was the most common type (55.16%) and metatypical type had the lowest frequency (3.7%). Head and neck were the most common sites of all subtypes of this tumor and nose was the most common of involvement (22.7%). Conclusion: Superficial BCC was more common on the scalp, which is due to irradiation used for the treatment of tinea capitis in the past.