Talat Humaira; Wahid Zarnaz; Mirza Reema
Volume 15, Issue 4 , 2012, , Pages 122-126
Abstract
Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations ...
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Background: This study was conducted because up to now,the investigations performed on cutaneous manifestations ofantihypertensive agents’ reactions, especially in Pakistan, arenegligible even though these drugs are taken by a large numberof people. The aim of this study was to determine the cutaneousmanifestations of different antihypertensive agents in terms ofdosage and duration.Method: The study was carried out at the Departments ofDermatology and Cardiology, Civil Hospital, Karachi. The studywas carried out from June 2007 to December 2007. The inclusioncriteria included all patients taking a single antihypertensive agentwith cutaneous manifestations. Patients taking antihypertensivedrugs but suffering from some other dermatological diseases andthose taking more than one drug were excluded. After informedconsent, history, specifically regarding the type of drug dosageand duration of drug intake was taken. Specific investigationssuch as biopsy were done if indicated.Result: Out of 100 patients, 37 were male and 63 were female.Most of the patients were in the age group 46–60 years. Themajority (97%) of patients experienced the onset of lesions between4–8 weeks of therapy and only 2% had lesions within 4 weeks.Moderate lesions were markedly more common and were foundin 65% followed by mild lesions in 26%, severe in 6%, and lethalin 3% of the patients. The most common lesions were pruritisand eczema, followed by flushing, lichenoid eruptions, oralulcers, purpuras, psoriasis, exanthematous reactions, urticaria,gingival hyperplasia, lichen planus, morbilliform rashes, orallichen planus and butterfly rash.Conclusion: No relation was noted between a drug dose andthe severity of skin lesions. Most patients started having skinlesions 4 to 8 weeks after therapy..
Kambiz Kamyab; Samaneh Jamshidi; Hamed Ghasemi; Maryam Seraj
Volume 14, Issue 1 , 2011, , Pages 35-36
Abstract
Granuloma annulare represents a reaction pattern that is recognized as idiopathic in many cases but is attributed to a variety of inciting factors in some cases. In this report, we present a case of granuloma annulare-like pattern reaction to tattoo pigment.
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Granuloma annulare represents a reaction pattern that is recognized as idiopathic in many cases but is attributed to a variety of inciting factors in some cases. In this report, we present a case of granuloma annulare-like pattern reaction to tattoo pigment.
Nasiri Soheila; Rahimi Hoda; Farnaghi Ali
Volume 12, Issue 4 , 2009, , Pages 123-126
Abstract
Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical ...
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Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical and paraclinical characteristics of these cases. Methods: All records of patients who were hospitalized at our hospital with a diagnosis of cutaneous drug reaction due to anticonvulsant therapy between March 2006 and September 2009 were reviewed. Results: The most common offending drug was lamotrigine. The main indication of anticonvulsant therapy was for idiopathic seizures. The most frequent type of cutaneous reaction was maculopapular and/or erythrodermic rash. Eosinophilia was detected in 56.5% of the patients. Conclusions: Although serious reactions with AEDs are not common, they may be life threatening. So, timely and accurate diagnosis can prevent fatal reactions and affects subsequent anticonvulsant treatment options.