M Danesh Pajouh; K Balighi; F Safar; M Asheghan; M Asadollahi; Gh.R Hassiri
Volume 8, Issue 4 , 2005, , Pages 272-275
Abstract
Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. ...
Read More
Background and objective: Psoriasis is chronic inflammatory skin disorder with a wide variety of clinical presentations. Presence of anti-gliadin antibody (AGA) has been reported in 16% of psoriatic patients. This study was designed to determine the frequency of the presence of AGA in psoriatic patients. Materials and Methods: After recording the demographic data and the severity of disease according to PASI scoring system, serum of 10 psoriatic patients and 100 healthy controls were studied for the presence of AGA using indirect innumofluorescence method. Results: AGA was present in sera of 4 (3 males and one female) psoriatic patient while all controls were negative. Three patients were from 20 to 40 years of age. All four AGA positive patients suffered from plaque type psoriasis. The disease severity was mild in one, moderate in two, and severe in one patient. None of them suffered from gastrointestinal problems. Conclusion: Although AGA may be present in the serum of some psoriatic cases, a significant relation between skin lesion and hypersensivity to gluten has not been determined yet. More studies using more specific and sensitive assessment methods and larger sample sizes are suggested.
SZ Ghodsi; H Ghani Nezhad; L Farpoor; A Ali Mardani; A Taheri; P Mansoori
Volume 8, Issue 2 , 2005, , Pages 115-120
Abstract
Background: Geographic tongue is an inflammatory disorder of unknown etiology that affects the epithelium of the tongue. It has been associated with several cutaneous diseases. Objective: To determine the prevalence of geographic tongue and its association with other cutaneous diseases in patients referred ...
Read More
Background: Geographic tongue is an inflammatory disorder of unknown etiology that affects the epithelium of the tongue. It has been associated with several cutaneous diseases. Objective: To determine the prevalence of geographic tongue and its association with other cutaneous diseases in patients referred to the dermatology clinic of Razi hospital. Patients and methods: A cross-sectional study was performed on all patients referred to one of the dermatology clinics of Razi hospital between February 21 and March 18, 1996 to determine the prevalence of geographic tongue and other diseases. Results: One-thousand and one-hundred and sixty referred patients were studied. The prevalence of geographic tongue was 6.2%. There was a statistically significant association between geographic tongue and seborrheic dermatitis (P=0.0053). Conclusion: Geographic tongue is associated with some cutaneous diseases. Detection of these associations could be a clue to the etiology and pathogenesis of geographic tongue.
M Barzegari; H Ghaninejad; M Shizarpoor
Volume 7, Issue 4 , 2004, , Pages 237-241
Abstract
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. ...
Read More
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. Patients and Methods: 40 patients with generalized plaque type psoriasis with PASI scores of 15-20 in Razi Hospital in Tehran were randomly divided into 2 groups after giving consent. Each group included 20 patients. The first group was treated three times a week with bath-PUVA and the second group was treated with acitretin 0.7 mg/kg/day. The efficacy of 2 treatment regimens were determined and compared using PASI scores. Results: The clearance rate was 65% in bath-PUVA group and 75% in acitretin group. Patients in bath-PUVA needed 29 sessions and accumulative dose of 105.46 J/cm² for clearance. Conclusion: Psoriasis patients responded to bath-PUVA treatment but this response required more sessions and higher total dose. The inherent differences and distinctive responses to light in the patients under study (In Iran) compared with patients with skin phototypes I, II might explain these differences.
F Farnaghi; H Seirafi; AR Firooz; F Jamshidi
Volume 7, Issue 1 , 2003, , Pages 19-23
Abstract
Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional ...
Read More
Background: Psoriatic arthropathy is a seronegative arthropathy seen in some patients with psoriasis, a self-limited and genetically determined skin disease. Objective: To determine the prevalence and risk factors of arthropathy in patients with psoriasis. Patients and Methods: In a prospective, cross-sectional study, psoriatic patients referred to Razi Skin Hospital in Tehran, Iran in 2002 were evaluated for the presence of arthropathy, and were referred to a rheumatologist for confirmation of arthropathy. The relationship between and nail involvement were evaluated using chi-square and t tests. Results: Among 320 patients with psoriasis, 29 (9.1%) had joint diseases. The most common was asymmetric polyarthritis. Patients with joint diseases had more nail involvement (96.5% vs. 73.1%, P<0.05) and higher mean PASI scores (24.33±10.35 vs. 10.70±8.44, P<0.05) than those without arthropathy, but the age and sex distribution of two groups were not significantly different. Conclusion: The prevalence of joint diseases in psoriatic patients in this study was similar to other reports. Nail involvement and more extensive disease are risk factors for joint diseases in these patients.
Sh Enshaieh; A Kiani; A Yazdani
Volume 6, Issue 3 , 2003, , Pages 19-23
Abstract
Background: It seems that psychological factors have important role in beginning or exacerbation of psoriasis. On the other hand, psoriasis negatively impacts quality of lives of the patients. Objective: To determine the frequency of depression and anxiety disorders in psoriatic patients. Patients and ...
Read More
Background: It seems that psychological factors have important role in beginning or exacerbation of psoriasis. On the other hand, psoriasis negatively impacts quality of lives of the patients. Objective: To determine the frequency of depression and anxiety disorders in psoriatic patients. Patients and Methods: In this descriptive study we evaluated 83 psoriatic patients referred to dermatologic clinics in Isfahan from 1379 to 1380. Beck and zoonge questionnaires were completed by the patients to evaluate depression and anxiety, respectively. Analysis of data was done by SPSS program with 95% confidence interval. Results: The frequency of depression in the patients was 69.9%. The most common type of depression was “Relative depression” (26.5%). The frequency of anxiety in psoriatic patients was 20.5%. These figures are higher than that reported in general population in Isfahan. Conclusion: The frequencies of depression and anxiety disorders in psoriatic patients were higher than general population. There was a direct correlation between the duration of disease and the prevalence of depression and anxiety disorders.
B Nabaei; H Safizadeh; Z Halaji
Volume 5, Issue 3 , 2002, , Pages 15-21
Abstract
Background: The reduction of disability caused by psoriasis is an important issue in dermatology. It is thus important to assess the patients’ appraisal of their quality of life. Objective: The aim of the present study was to assess quality of life among patients with psoriasis and to compare these ...
Read More
Background: The reduction of disability caused by psoriasis is an important issue in dermatology. It is thus important to assess the patients’ appraisal of their quality of life. Objective: The aim of the present study was to assess quality of life among patients with psoriasis and to compare these estimates with general population. Patients and Methods: In this cross-sectional study, 55 patients and 55 control subjects were interviewed in Tehran Razi hospital. Quality of life was assessed by SF-36 and PDI questionnaires. Results: After score calculation in any domain of SF-36, it was seen that psoriasis patients reported significantly lower scores than the normal control subjects in all scales, except for physical functioning. The greatest difference was found in social functioning. The smallest difference was noticed in vitality. The psoriasis disability index score (PDI) was negatively correlated with all of the eight of the SF-36 health measures in psoriatic patients. Conclusion: These results show that psoriasis patients report poorer quality of life than general population. Therefore, in the case of these patients one most pay attention to the impact of this disease on different life domains.
S Family
Volume 5, Issue 1 , 2001, , Pages 3-8
Abstract
Background: Psoriasis is a common disease of the skin. Metabolic disorders have been suggested in the etiology of psoriasis. Objective: As hypocalcemia has been reported to provoke psoriasis, we studied the blood calcium level in this disease. Patients and Methods: In this case-control study, we measured ...
Read More
Background: Psoriasis is a common disease of the skin. Metabolic disorders have been suggested in the etiology of psoriasis. Objective: As hypocalcemia has been reported to provoke psoriasis, we studied the blood calcium level in this disease. Patients and Methods: In this case-control study, we measured blood calcium level in 120 psoriatic patients visited in outpatient clinic or admitted in Ghahem Hospital in Mashhad and compared to 120 age and sex matched normal controls. Results: Considering blood calcium level of 8.5-10.5 mg/dl as normal, 17 psoriatic patients (14%) and 6 controls (5%) were hypocalcemic (P<0.05). Conclusion: As hypocalcemia in psoriatic patients was significantly more common in this study, estimation of blood calcium level is recommended in psoriasis.
M Karayi; M Radmanesh; ZB Mousavi; N Darvishi Zadeh
Volume 3, Issue 4 , 2000, , Pages 29-33
Abstract
Background: Psoriasis is a common and genetically determined skin disease, which is frequent throughout the world. Objective: To perform a descriptive clinical study of 200 cases of psoriasis in Ahwaz. Patients and Methods: This study was performed from November 1997 to April 1999 on 200 psoriatic patients ...
Read More
Background: Psoriasis is a common and genetically determined skin disease, which is frequent throughout the world. Objective: To perform a descriptive clinical study of 200 cases of psoriasis in Ahwaz. Patients and Methods: This study was performed from November 1997 to April 1999 on 200 psoriatic patients attended a private skin clinic in Ahwaz. Data were collected from patients and entered in questionnaires. Results: 56% of the patients were female and 44% were male. The age of onset was in the 1st, 2nd, 3rd and 4th decades in 24.2%, 33.5%, 18.5% and 10%, respectively. Their age was in the 1st, 2nd, 3rd and 4th decades in 23.5%, 28.5%, 17.5% and 14%, respectively. Only few cases referred with later ages of onset. In 40% of the cases the disease started from the scalp. 9% of the patients reported positive Koebner phenomenon. A positive family history for psoriasis was found in 25%. Nail involvement was detected in 39% of the patients. Conclusion: Psoriasis in Ahwaz shows a similar pattern to the other parts of world.
E Firooz Ebne Ahmadi; P Sooudi; Y Dowlati
Volume 2, Issue 3 , 1999, , Pages 15-20
Abstract
Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed ...
Read More
Introduction: Since there is no study in our country about determination the effects of psychogenic factors on psoriasis and because it seems necessary to evaluate the triggering factors of disease in order to lengthen the remission period and decrease the costs and complications, this study was performed to identify the relationship of stress with psoriasis expression and the severity of skin lesions. Materials and Methods: This is a prospective case-control study with simple random sampling which has been performed on 95 subjects above 18 year old in Razi Hospital. The case group was selected from psoriatic patients and the control group from non-psoriatic patients in whom stress does not have any effect on their disease. Two groups were matched for age and sex. Stress was assessed by Holmes and Rahe protocol with some modifications approved by a psychiatrist. Severity of skin lesions in psoriatic patients was also assessed by PASI score. Data Analysis was performed by T test, multiple logistic regression and correlation of Spearman using SPSS (6) software. Results: The mean of severity of stress in psoriatic group was higher than control group (P=0.021). On the other hand, there was a relationship between stress and psoriasis expression; but there was no statistically significant correlation between severity of stress and severity of skin lesions in psoriatic patients (P=0.268). Discussion: Paying attention to the effect of stress on the expression of psoriasis, it is suggested to use psychological methods in addition to routine treatment: So we can reduce emotional stress and shorten the course of this disease.