MJ Nazemi; AH Ehsani; M Ghiasi; R Mahmooud Robati; F Gouran
Volume 9, Issue 2 , 2006, , Pages 122-126
Abstract
Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study ...
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Background and aim: Acne vulgaris is a chronic disease of pilosebaceous units which most commonly affects younger people. There are many different treatment modalities; each affects some mechanisms of acne pathogenesis. Systemic antibiotics are one of the most popular methods of treatment. In this study the efficacy of oral erythromycin was compared with doxycyclin in the treatment of moderate to severe acne vulgaris.Materials and Methods: This study was planned and conducted as a double-blind clinical trial. Sixty eight patients with acne were divided into two groups. One group was treated with oral erythromycin with a dose of 1g/day and the other group received oral doxycyclin at a dose of 100 mg/day for 4 months. The clinical improvement was evaluated based on reduction in the number of lesions in each monthly visit. Adverse events were also recorded.Results: Both groups showed considerable improvement in the lesions of face and trunk wih no significant difference. There was also no significant difference between improvement in facial and truncal lesions in the patients treated with erythromycin but facial lesions significantly improved more than trucal ones in patients on doxycyclin.Conclusion: The efficacy of oral erythromycin and doxycyclin was not significantly different in the treatment of acne vulgaris and each of them can be used according to the clinical status of the patients.
M Akhyani; H Mortazavi; M Izadi; AH Ehsani
Volume 7, Issue 1 , 2003, , Pages 14-18
Abstract
Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin ...
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Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin in the treatment of patients with pityriasis rosea. Patients and Methods: In this double-blind randomized clinical trial, 46 patients with pityriasis rosea in two equal groups were treated with oral erythromycin 1gr per day or placebo for seven days and were followed 1, 2 and 6 weeks after treatment. The response to the treatment was evaluated as complete, partial and no response. Results: In 48% of the case group and 13% of the control group complete response was seen at the end of first week of treatment. Moreover, these rates reached 91% and 57% at the end of second week, 100% and 87% at the end of sixth week, respectively. The differences between two groups were statistically significant after first and second weeks. Conclusion: Oral erythromycin was effective in the treatment of patients with pityriasis rosea. Also, it reduces the duration of disease.
L Dastgheib; A Alborzi; F Djokar; B Abudi; M Kalani
Volume 6, Issue 1 , 2002, , Pages 5-9
Abstract
Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. ...
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Background: Acne vulgaris is a self-limited disease that mainly involves the sebaceous follicles. Systemic antibiotic is a common therapeutic modality, so bacterial resistance can be a problem. Objectives: Assessment of Propionibacterium resistance to erythromycin, tetracycline, clindamycin and spiramycin. Patients and Methods: Sampling was done on lesions of 123 patients with acne vulgaris who referred to dermatology clinic of Shahid Dr. Faghihi hospital in Shiraz. After isolation and confirmation of P.acne minimal inhibitory concentration (MIC) of above-mentioned antibiotics were measured with agar dilution test. Results: From 123 patients, 129 samples were taken. Presence of P.acnes was confirmed in 62 samples. MICs for antibiotics were: Tetracycline 0.03-0.125 µg/ml, erythromycin 0.015-0.06 µg/ml, clindamycin 0.03-0.5 µg/ml and spiramycin 0.015-0.25 µg/ml. Conclusion: The samples of P.acnes isolated from acne vulgaris lesions in this study were sensitive to above mentioned antibiotics.
