@article { author = {Aminuddin, Liyana D and Taib, Tarita and Isa, Mohamad Rodi and Arumugam, Mohan and A Wahab, Sabrina}, title = {Efficacy of topical silicone 5% hydrogel vs. topical hydrocortisone 1% ointment in keloid treatment measured using POSAS score: a randomized, double-blind study}, journal = {Iranian Journal of Dermatology}, volume = {26}, number = {1}, pages = {6-14}, year = {2023}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {10.22034/ijd.2021.263003.1296}, abstract = {Background and Aim: Silicone-based products are often used to improve signs and symptoms of hypertrophic and keloid scars. An improved silicone product, ScarLess™ Hydrogel (SH), is a 5% silicone-based super-oxidized hydrogel meant to reduce keloid scars’ vascularity, elasticity, and height. This study aimed to compare the efficacy between SH and hydrocortisone (HCT) 1% ointment in keloid treatment.Methods: This study was a prospective, single-centered, randomized, double-blind study involving twenty-eight subjects with keloid scars. The scars were assigned randomly as Scar A and Scar B in a 1:1 ratio to receive HCT or SH under occlusion, respectively, for over 12 weeks. The Patient and Observer Scar Assessment Scale (POSAS) was used for clinical evaluation.Results: According to the POSAS, there were significant improvements in both patient and observer scorings in both treatment arms.Conclusion: SH has equal therapeutic efficacy as HCT in keloid treatment. SH did not present with any safety issues or side effects.}, keywords = {keloid,Silicone gel,Scar,hypertrophic scar,POSAS}, url = {https://www.iranjd.ir/article_169986.html}, eprint = {https://www.iranjd.ir/article_169986_a548e097ae77cc6597f23263e0805042.pdf} }