@article { author = {Habib, Ansarin and Mahshid, Firoozeh and Alireza, Sadeghipour and Leila, Tajziehchi}, title = {Gli 1 protein expression in different types of basal cell carcinoma}, journal = {Iranian Journal of Dermatology}, volume = {10}, number = {3}, pages = {211-218}, year = {2007}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1. Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sex or history of radiotherapy in our patients.Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis.}, keywords = {Basal cell carcinoma,Gli 1 protein,Hedgehog signal}, url = {https://www.iranjd.ir/article_97999.html}, eprint = {} }