@article { author = {Asilian, A and Nilforooshan, Z}, title = {Safety and efficacy of Capsaicin gel in painful and pruritic dermatoses: Post-Herpetic neuralgia, Notalgia Paresthetica, Lichen simplex chronicus}, journal = {Iranian Journal of Dermatology}, volume = {5}, number = {2}, pages = {3-10}, year = {2002}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical capsaicin is effective due to depletion of never endings from substance P. Objective: The efficacy and side effects capsaicin gel in painful and pruritic skin disorders was compared to placebo. Patients and Methods: In a controlled clinical trial, 40 patients (21 patients with post-herpetic neuralgia, 10 with lichen simplex chronicus, and 9 with notalgia paresthetica), with the mean age of 48 years were randomly treated with 0.075% capsaicin gel or placebo q.i.d. for 4 weeks. The severity of symptoms and side effects were assessed every two weeks and recurrence was assessed also two months after treatment. Results: 31 cases (77%) completed their 4 weeks treatment period. According to visual Analogue Score system, the mean of symptom severity decreased from 7.6 (±2.4) before treatment to 0.9 (±0.9) after treatment in capsaicin group and decreased from 6.3 (±2.3) to 5.0 (±3.2) in placebo group (P<0.05). Conclusion: Capsaicin gel is effective in painful and pruritic skin disorders and has tolerable side effects.}, keywords = {capsaicin,Post-herpetic neuralgia,Lichen simplex chronicus,Notalgia paresthetica}, url = {https://www.iranjd.ir/article_98438.html}, eprint = {https://www.iranjd.ir/article_98438_c6e0fd8787ef8e52198280850e29d2ee.pdf} }