@article { author = {Hallaji, Zahra and Lajevardi, Vahideh and Abedini, Robabeh and Soleymani, Amir and Goodarzi, Azadeh and Salehi-Taleghani, Mehrnaz and Beygi, Sara}, title = {Serum leptin levels in psoriatic patients with non-alcoholic fatty liver disease}, journal = {Iranian Journal of Dermatology}, volume = {19}, number = {4}, pages = {125-130}, year = {2016}, publisher = {Iranian Society of Dermatology}, issn = {2717-0721}, eissn = {2717-0721}, doi = {}, abstract = {Background: The prevalence of non-alcoholic fatty liver disease is higher in patients with psoriasis than in the normal population. Serum leptin levels are higher in patients with psoriasis and in patients with non-alcoholic fatty liver. The purpose of this study was to determine the serum levels of leptin in psoriatic patients with and without non-alcoholic fatty liver.Methods: This cross-sectional study was conducted at Razi Dermatology Hospital, Tehran, Iran in 2013. A total of 50 patients with psoriasis were enrolled in the study. Fatty liver grade was assessed via ultrasonography and serum leptin levels were measured using the ELISA method.Results: Ten patients had normal livers and 40 had fatty livers with different grades. The median serum leptin level was significantly higher in psoriatic patients with fatty liver (11.75ng/mL) in comparison to those without fatty liver (2.80 ng/ml). Moreover, there was a direct correlation between the leptin level and the grade of fatty liver.Conclusion: serum leptin can be elevated in the course of psoriasis and may have a role in the pathogenesis of non-alcoholic fatty liver disease and other metabolic co morbidities in psoriatic patients.}, keywords = {Psoriasis,non-alcoholic fatty liver,leptin}, url = {https://www.iranjd.ir/article_99441.html}, eprint = {https://www.iranjd.ir/article_99441_736b8c98e513b3012077ba740076267b.pdf} }