%0 Journal Article %T Efficacy of topical silicone 5% hydrogel vs. topical hydrocortisone 1% ointment in keloid treatment measured using POSAS score: a randomized, double-blind study %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Aminuddin, Liyana D %A Taib, Tarita %A Isa, Mohamad Rodi %A Arumugam, Mohan %A A Wahab, Sabrina %D 2023 %\ 03/01/2023 %V 26 %N 1 %P 6-14 %! Efficacy of topical silicone 5% hydrogel vs. topical hydrocortisone 1% ointment in keloid treatment measured using POSAS score: a randomized, double-blind study %K keloid %K Silicone gel %K Scar %K hypertrophic scar %K POSAS %R 10.22034/ijd.2021.263003.1296 %X Background and Aim: Silicone-based products are often used to improve signs and symptoms of hypertrophic and keloid scars. An improved silicone product, ScarLess™ Hydrogel (SH), is a 5% silicone-based super-oxidized hydrogel meant to reduce keloid scars’ vascularity, elasticity, and height. This study aimed to compare the efficacy between SH and hydrocortisone (HCT) 1% ointment in keloid treatment.Methods: This study was a prospective, single-centered, randomized, double-blind study involving twenty-eight subjects with keloid scars. The scars were assigned randomly as Scar A and Scar B in a 1:1 ratio to receive HCT or SH under occlusion, respectively, for over 12 weeks. The Patient and Observer Scar Assessment Scale (POSAS) was used for clinical evaluation.Results: According to the POSAS, there were significant improvements in both patient and observer scorings in both treatment arms.Conclusion: SH has equal therapeutic efficacy as HCT in keloid treatment. SH did not present with any safety issues or side effects. %U https://www.iranjd.ir/article_169986_a548e097ae77cc6597f23263e0805042.pdf