%0 Journal Article %T Gli 1 protein expression in different types of basal cell carcinoma %J Iranian Journal of Dermatology %I Iranian Society of Dermatology %Z 2717-0721 %A Habib, Ansarin %A Mahshid, Firoozeh %A Alireza, Sadeghipour %A Leila, Tajziehchi %D 2007 %\ 10/01/2007 %V 10 %N 3 %P 211-218 %! Gli 1 protein expression in different types of basal cell carcinoma %K Basal cell carcinoma %K Gli 1 protein %K Hedgehog signal %R %X Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1. Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sex or history of radiotherapy in our patients.Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis. %U