TY - JOUR ID - 143678 TI - A study of severe cutaneous adverse drug reactions in Iranian patients JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - Mortazavi, Hossein AU - Mortazavi, Arileza AU - Rostami, Anahita AU - Javadi, Mohammadraza AU - Abedini, Robabeh AU - Teimourpour, Amir AU - Gholami, Kheirolah AU - Khamesipour, Ali AD - Department of Dermatology, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran AD - Department of Clinical Pharmacy school of pharmacy, Tehran University of Medical Sciences, Tehran, Iran AD - Center for Research and Training in Skin Diseases and Leprosy AD - Department of Clinical Pharmacy school of pharmacy, Tehran University of Medical Sciences, Tehran, Iran. AD - Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences Y1 - 2021 PY - 2021 VL - 24 IS - 4 SP - 267 EP - 273 KW - adverse drug reaction reporting system KW - anticonvulsant KW - antimalarial KW - Antibiotic DO - 10.22034/ijd.2020.230212.1097 N2 - Background: Little data on severe cutaneous adverse drug reactions (SCADRs) is available, especially in Iran. Therefore, there is a need for more studies in this field. We aimed to evaluate the clinical pictures and laboratory data of patients with SCADR in a tertiary dermatology center in Tehran, Iran.Methods: In this retrospective study, patients with a clinical diagnosis of SCADR based on the World Health Organisation’s definition and histopathologic findings were included. Causality and preventability measures were assessed based on previous criteria, including the Naranjo score and the Schomock and Thronton scale.Results: Thirty-nine patients with a mean age of 43 ± 17 years participated in the study. SCADRs were more common in females than in males (2.9/1). SCADRs included Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis (AGEP), and drug reactions with eosinophilia and systemic symptoms (DRESS). Thirty-one patients presented a Naranjo score of 5-8, indicating probable drug reactions. The remaining eight patients (with scores of 1-4) were determined as having possible drug eruptions. Regarding the category of culprit drugs, anticonvulsants (49%), antimalarials (15%), antibiotics (13%), and antihypertensives (10%) were themost frequent causes of SCADR, with lamotrigine being the single most common agent.Conclusion: The most frequent clinical presentation of SCADR was SJS/TEN, followed by AGEP and DRESS. The most frequent cause of SCADR was anticonvulsant drugs. UR - https://www.iranjd.ir/article_143678.html L1 - https://www.iranjd.ir/article_143678_25a87864cbaf1bcc9873d095f77685ca.pdf ER -