TY - JOUR ID - 97999 TI - Gli 1 protein expression in different types of basal cell carcinoma JO - Iranian Journal of Dermatology JA - IJD LA - en SN - AU - Habib, Ansarin AU - Mahshid, Firoozeh AU - Alireza, Sadeghipour AU - Leila, Tajziehchi AD - Y1 - 2007 PY - 2007 VL - 10 IS - 3 SP - 211 EP - 218 KW - Basal cell carcinoma KW - Gli 1 protein KW - Hedgehog signal DO - N2 - Background and aim: Basal cell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal are Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1. Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sex or history of radiotherapy in our patients.Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis. UR - https://www.iranjd.ir/article_97999.html L1 - ER -