Iranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Ultrasonographic evaluation of subclinical atherosclerosis in the femoral and carotid arteries of patients with psoriasis30931416657610.22034/ijd.2020.233923.1115ENAkshay JainSalechaDepartment of D.V.L, Dr.
Pinnamaneni Siddhartha Institute
of Medical Sciences and Research
Foundation, Chinaoutapalli, NTR
District, Andhra Pradesh, IndiaSanth Kumar BellamkondaDepartment of Radiodiagnosis, Dr.
Pinnamaneni Siddhartha Institute
of Medical Sciences and Research
Foundation, Chinaoutapalli, NTR
District, Andhra Pradesh, IndiaHaritha SamanthulaDepartment of D.V.L, Dr.
Pinnamaneni Siddhartha Institute
of Medical Sciences and Research
Foundation, Chinaoutapalli, NTR
District, Andhra Pradesh, India.Sujit Kumar PonugotiDepartment of D.V.L, Dr.
Pinnamaneni Siddhartha Institute
of Medical Sciences and Research
Foundation, Chinaoutapalli, NTR
District, Andhra Pradesh, IndiaAnusha JakkampudiDepartment of D.V.L, Dr.
Pinnamaneni Siddhartha Institute
of Medical Sciences and Research
Foundation, Chinaoutapalli, NTR
District, Andhra Pradesh, IndiaJournal Article20200604<strong>Background:</strong> Psoriasis is a prevailing continual inflammatory<br />affliction, carrying a considerable risk of cardiac diseases,<br />sometimes even not traceable by conventional predisposing<br />factors. Detection of subclinical atherosclerosis in psoriasis by<br />ultrasonography is beneficial, and it has been solitarily explored<br />in carotid arteries. It was found to have a weak predictive value,<br />and so the femoral arteries have now been contemplated. This<br />study aims to determine subclinical atherosclerosis occurrence<br />by evaluating the femoral and carotid arteries’ intima-media<br />thickness (IMT) by ultrasonography in patients with psoriasis.<br /><strong>Methods:</strong> The study was carried out in the departments of<br />dermatology and radiology at Dr. Pinnamaneni Siddhartha<br />Institute of Medical Sciences & Research Foundation for eight<br />months. The sample size consisted of 30 chronic plaque psoriasis<br />cases and 30 controls, matched for age and sex. Patients with<br />comorbidities were excluded. Femoral & carotid arteries were<br />assessed for IMT by ultrasonography.<br /><strong>Results:</strong> In our study, the age range was 30–80 years, and a male<br />(56.7%) preponderance was observed in cases and controls. The<br />mean femoral artery and carotid artery IMTs were remarkably<br />greater in cases than in controls, with P-values < 0.001 and 0.04,<br />respectively. The mean femoral artery IMT was significantly more<br />elevated (1.4 ± 0.63 mm) than the carotid artery IMT (1.0 ± 0.62<br />mm) in cases (P = 0.01).<br /><strong>Conclusion</strong>: Ultrasonographic screening of femoral artery IMT<br />enhances the early discernment of subclinical atherosclerosis when<br />compared with carotid artery IMT. Thereby, it helps in the early<br />identification of cardiovascular disease in patients with psoriasis.<br />Keywords: femoral artery, carotid artery, intima-media thickness,<br />psoriasis, atherosclerosishttps://www.iranjd.ir/article_166576_c82dbb8a9e7892f7b0d66c0a26c385f9.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Serum folic acid, vitamin B12, vitamin D, and homocysteine levels in Iranian children with vitiligo31532016657710.22034/ijd.2021.249213.1220ENSaeedeh FarajzadehLeishmaniasis Research Center,
Kerman University of Medical
Sciences, Kerman, Iran0000-0002-7812-3452Mahin AflatoonianDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, IranSaman MohammadiDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, IranHamid SharifiHIV/STI Surveillance Research
Center and WHO Collaborating
Center for HIV Surveillance, Institute
for Futures Studies in Health,
Kerman University of Medical
Sciences, Kerman, IranMaryam KhaliliDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, Iran0000-0003-1866-7092Journal Article20200920<strong>Background:</strong> Hyperhomocysteinemia and vitamin D deficiency may<br />be involved in the pathogenesis of vitiligo. This study compared<br />the serum levels of vitamin D, homocysteine, vitamin B12, and<br />folic acid between vitiligo-affected children and healthy children.<br /><strong>Methods:</strong> Using a case-control design, 30 children with vitiligo<br />and 30 age and sex-matched healthy children were enrolled<br />from April 2018 to August 2020. Serum levels of vitamin D,<br />homocysteine, vitamin B12, and folic acid were analyzed in both<br />groups during the same season of the year. Additionally, the<br />association between serum levels of these factors with demographic<br />and clinical features of the children (collected by interview and<br />physical examination) was evaluated. Data were analyzed using<br />the independent T-test, Fisher’s exact test, and chi-squared test.<br /><strong>Results:</strong> The vitiligo group had significantly lower vitamin D<br />and folic acid serum levels compared with the control group<br />[95% CI -19.87 to -2.96 and -4.15 to -4.18, respectively]. Among<br />patients, the vitamin D level was negatively correlated with age<br />(r = -0.459, P = 0.011) and disease duration (r = -0.373, P = 0.042).<br />Moreover, there was a significant association between vitiligo<br />activity and serum homocysteine levels (P = 0.027).<br /><strong>Conclusion:</strong> Routine measurement of vitamin D and folic acid<br />serum levels might be suggested, especially in children with<br />long-standing disease. Monitoring the homocysteine level may<br />be beneficial, particularly in children with progressive vitiligo.<br /><br />https://www.iranjd.ir/article_166577_3af93925f3a7b6f482dda34c9b1372d0.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Prevalence of metabolic syndrome and its relationship with mucosal involvement in lichen planus: an observational study32132716657810.22034/ijd.2021.281894.1359ENArunima DhabalDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, India0000-0003-2553-6453Jayanta KumarBaruaDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, IndiaKingshuk ChatterjeeDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, India0000-0002-6351-1671Ananya ChandraDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, IndiaSumana KhanDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, IndiaManab KumarGhoshDepartment of Tropical Medicine,
School of Tropical Medicine,
Kolkata, IndiaSaswati HalderDepartment of Dermatology,
Venereology and Leprosy, School of
Tropical Medicine, Kolkata, IndiaJournal Article20210418<strong>Background:</strong> Lichen planus (LP) is a chronic inflammatory<br />disorder involving the skin, mucosa, hair, and nails. Previous<br />reports have shown a possible association between LP and<br />metabolic derangement, leading to increased cardiovascular risk<br />among these patients. Our study aimed to assess the prevalence<br />of metabolic syndrome (MetS) and its components in LP patients<br />and to study their relationship with mucosal involvement in LP.<br /><strong>Methods:</strong> We conducted a cross-sectional observational study of<br />123 LP patients. Demographic and clinical data were obtained,<br />and evaluation was done for the presence of abdominal obesity,<br />hypertension, hyperglycemia, and dyslipidemia. MetS was<br />diagnosed according to the modified National Cholesterol<br />Education Program: Adult Treatment Panel III (NCEP-ATP III)<br />criteria for the South Asian population. Data analysis was done<br />using appropriate statistical methods.<br /><strong>Results:</strong> The prevalence of MetS in LP patients was 31%. The mean<br />age of LP patients having MetS was considerably higher than<br />those without MetS (44.8 ± 13.6 vs. 33.3 ± 15.9 years; P = 0.0002).<br />Although statistically insignificant, female patients and patients with<br />mucosal involvement showed a higher prevalence of MetS. Central<br />obesity, hypertension, hyperglycemia, and hypertriglyceridemia<br />were more prevalent in mucosal LP patients than in those without<br />mucosal lesions, with hyperglycemia having a significantly higher<br />prevalence in mucosal LP (41% vs. 18%; P = 0.015).<br /><strong>Conclusion:</strong> Incre ased age, female gender, and mucosal<br />involvement are important predictors of concurrent metabolic<br />derangement in LP patients. Thus, these patients should be<br />screened for the presence of MetS and its components.<br /> https://www.iranjd.ir/article_166578_258380068be160ebdad54cdf58c6fc48.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Predictive factors associated with antimony treatment failure in anthroponotic cutaneous leishmaniasis in Kerman: a case-control study32833516657910.22034/ijd.2022.308945.1441ENMaryam KhaliliDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, Iran0000-0003-1866-7092Saman MohammadiDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, IranMohamadhosein SaeidiDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, IranRezvan AmiriLeishmaniasis Research Center,
Kerman University of Medical
Sciences, Kerman, IranAmireh HeshmatkhahShahid Davari Clinic, Kerman
University of Medical Sciences,
Kerman, IranSimin Shamsi MeymandiPathology and Stem Cell Research
Center, Afzalipour Hospital, Kerman
University of Medical Sciences,
Kerman, Iran0000-0001-6172-5994Mahin AflatoonianDepartment of Dermatology,
Kerman University of Medical
Sciences, Kerman, IranJournal Article20211004<strong>Background: </strong>Treatment failure of antimony drugs for anthroponotic<br />cutaneous leishmaniasis (ACL) is rising. Recognizing predictive<br />factors of unresponsiveness to treatment can substantially<br />influence better ACL management. The goal of this study was<br />to investigate predictive factors associated with treatment failure<br />in ACL in Kerman, southeast Iran.<br /><strong>Methods:</strong> This case-control study was conducted retrospectively<br />on 2,128 ACL cases in Kerman over ten years from 2011 to 2020.<br />The case group included patients whose lesions failed to resolve<br />after one treatment course. The control group included those<br />whose lesions were cured after one treatment course.<br /><strong>Results:</strong> Treatment failure was observed in 13.5% of cases (10.7%<br />of systemic therapy and 16.7% of local therapy). No significant<br />difference was reported between the type of treatment and<br />treatment failure. The association of treatment failure with<br />winter-onset (P = 0.001, OR = 1.39, CI = 1.23–1.56), face (P = 0.001,<br />OR = 1.86, CI = 1.38–2.49), ulceration (P = 0.01, OR = 0.51, CI = 0.30–<br />0.85), small diameter (P = 0.005, OR = 0.57, CI = 0.38-0.84) and<br />long duration of lesions (P = 0.01, OR = 1.57, CI = 1.11–2.21) was<br />validated by multivariate logistic regression analysis.<br /><strong>Conclusion:</strong> Efficient detection and timely management of ACL<br />cases are essential to reduce resistant cases, as lesions lasting<br />longer than four months show poor response to treatment.<br />Furthermore, early treatment of facial lesions with systemic<br />therapy is suggested to optimize results and reduce the risk of<br />disfiguring scars. Further surveys are required to determine the<br />reason behind more treatment failure in winter-onset lesions.<br /><br />https://www.iranjd.ir/article_166579_79817cbe0c6b3216ffa47f9011cb3528.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Epidemiological study of malignant melanoma in Kermanshah province of Iran in 2010-2016 based on the geographic information system33634416658010.22034/ijd.2022.290817.1384ENHossain KawosiDepartment of Dermatology, School
of Medicine, Kermanshah University
of Medical Sciences, Kermanshah,
IranNader SalariDepartment of Biostatistics, School
of Health, Kermanshah University
of Medical Sciences, Kermanshah,
IranArash Golpazir SorkheKermanshah Cancer Registry,
Kermanshah University of Medical
Sciences, Kermanshah, IranIbrahim ShakibaDepartment of Biochemistry, Faculty
of Medicine, Kermanshah University
of Medical Sciences, Kermanshah,
IranRoya SafarpourDepartment of Dermatology, School
of Medicine, Kermanshah University
of Medical Sciences, Kermanshah,
IranMasoud MohammadiCellular and Molecular Research
Center, Gerash University of
Medical Sciences, Gerash, Iran0000-0002-5722-8300Journal Article20210615<strong>Background: </strong>Malignant melanoma is a prevalent, offensive, and<br />fatal cancer in developed countries. Most of our information is<br />related to studies conducted in western countries. This study<br />aims to evaluate demographic and clinical data of melanoma in<br />the Kermanshah province of Iran.<br /><strong>Method: </strong>This was a descriptive study on data available in the<br />Cancer Registry Center of Kermanshah, which includes 70<br />patients during eight years from 2010–2017. Clinical recognition<br />of melanoma was based on American Joint Committee on Cancer<br />criteria. Data were analyzed by SPSS 20 software and shown in<br />ArcGIS (Version 10.7).<br /><strong>Results:</strong> Patients included 46 men (65.7%) and 24 women (34.3%)<br />with a mean age of 60.49 ± 16.08. The general prevalence of<br />melanoma was 4.4 in every 1,000,000 persons annually. Most<br />patients had skin type III (65.7%), indoor jobs (61.4%), and lived<br />in the city (67.1%). Also, 35.7% had a trauma history, 2.8% had<br />familial melanoma history, and 17.1% had other types of skin<br />cancer. Extremities (51.4%), acral lentiginous melanoma (50.1%),<br />Clark IV (61.4%), and inguinal lymph nodes (14.3%) were the<br />most prevalent location, clinical type, pathological level, and<br />involved lymph nodes, respectively.<br /><strong>Conclusion: </strong>Acral lentiginous melanoma and extremities<br />involvement are prevalent in our region. Most patients go to<br />doctors at an advanced level due to delays in referral, lack of<br />follow-up by patients, lack of recognition at the initial care level,<br />and lack of access to specialty centers. We recommend general<br />instructions through media and holding special workshops for<br />physicians for better familiarity with melanoma.<br /><br />https://www.iranjd.ir/article_166580_45e23ee1ca82a72c418c42b826580ee8.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Relationship between citation metrics and the characteristics of article titles in dermatology journals34535516658110.22034/ijd.2022.329134.1506ENMohammad Mahdi ParviziMolecular Dermatology Research
Center, Shiraz University of Medical
Sciences, Shiraz, Iran0000-0003-1856-945XFarhad HandjaniMolecular Dermatology Research
Center, Shiraz University of Medical
Sciences, Shiraz, IranDepartment of Dermatology, School
of Medicine, Shiraz University of
Medical Sciences0000-0002-2444-0073Leila GhahramaniDepartment of Medical Journalism,
Faculty of Paramedical Sciences,
Shiraz University of Medical
Sciences, Shiraz, IranNasrin ShokrpourEnglish Department, Faculty of
Paramedical Sciences, Shiraz
University of Medical Sciences,
Shiraz, IranJournal Article20220210<strong>Background: </strong>Evidence shows that article titles might affect<br />citation metrics. This study aimed to evaluate the association<br />between selected citation metrics and the title characteristics in<br />dermatology journals.<br /><strong>Methods:</strong> We enrolled 305 reviews and original articles published<br />during 2016 from four dermatology journals consisting of the<br />“Journal of the American Academy of Dermatology,” “Journal<br />of the European Academy of Dermatology and Venereology,”<br />“Indian Journal of Dermatology, Venereology and Leprology,”<br />and “International Journal of Dermatology” using a stratified<br />and simple random sampling method. The list of articles was<br />extracted from Scopus; then, the title characteristics were<br />reviewed. Moreover, we extracted the citation metrics, including<br />the citation count, Field-Weighted Citation Impact (FWCI), and<br />citation benchmarking percentile of the articles until the end of<br />October 2021 using Scopus. For statistical analysis, we used Stata<br />software version 14.2.<br /><strong>Results: </strong>Overall, 239 (78.36%) original and 66 (21.64%) review<br />articles were included. The citation count and FWCI significantly<br />and positively correlated with the number of words, characters,<br />and punctuation marks in the titles. By adjusting the covariates,<br />linear logistic regression showed that the title length and the<br />presence of acronyms in the title were the most effective factors<br />in increasing the citation count and FWCI of the articles.<br /><strong>Conclusion: </strong>Using longer titles and including acronyms in the<br />titles may help augment the citation of articles in dermatology<br />journals.<br /><br />https://www.iranjd.ir/article_166581_434ced3d1108e9c4a8b3f553f72a055c.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Efficacy and safety of 1064 nm long-pulsed neodymiumdoped yttrium garnet (Nd:YAG) laser for treating acne vulgaris: a prospective clinical trial35636216658210.22034/ijd.2021.286989.1371ENSamer ADhaherDepartment of Dermatology, College
of Medicine, University of Basrah,
Basrah, Iraq0000-0002-0001-4213Ali MYosifDepartment of Dermatology, Basrah
Teaching Hospital, Basrah, IraqJournal Article20210522<strong>Background: </strong>Acne vulgaris is a common chronic inflammation of<br />pilosebaceous units with a multifactorial pathogenesis. Traditional<br />treatment may have limited success with potential side effects.<br />The long-pulsed neodymium-doped yttrium garnet (Nd:YAG)<br />laser may be a desirable alternative.<br /><strong>Methods:</strong> A prospective clinical trial was conducted on 61 acne<br />patients at the Department of Dermatology, Basrah Teaching<br />Hospital, from April 2019 to April 2020. Three treatments with<br />long-pulsed Nd:YAG were performed across two-weeks intervals<br />(fluence 50 J/cm2, spot size 5 mm, pulse duration 15 ms, and<br />frequency 1.5 Hz). Patients were assessed at baseline and 2, 4,<br />6, and 12 weeks later by counting the acne lesions and scoring<br />the response according to the percentage of lesions’ reduction.<br /><strong>Results: </strong>Sixty-one patients completed the study (49 females<br />and 12 males); the mean age was 18.7 ± 1.67 years. A significant<br />reduction of acne lesions at the end of therapy was observed<br />compared to the baseline. The mean number of total lesions was<br />reduced from 84.2 ± 25.8 to 16 ± 23.3 (P < 0.05). Overall, 49 (80.3%)<br />patients achieved an excellent response, 3 (4.9%) good, 1 (1.6%)<br />moderate, and 8 patients (13.1%) showed a poor response. The<br />treatment was well tolerated with insignificant adverse effects.<br /><strong>Conclusion: </strong>Long-pulsed Nd:YAG laser is an effective and safe<br />modality for treating acne vulgaris and may be considered an<br />alternative option for cases of recurrence after conventional<br />treatment. However, more sessions are needed for severe cases.<br /><br />https://www.iranjd.ir/article_166582_5fd9c57d148cf994194743ca9dc136c1.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201A cutaneous-only variant of rheumatoid vasculitis with symmetric flexural pyoderma gangrenosum-like lesions36336616658310.22034/ijd.2021.258940.1278ENSunil GuptaDayanand Medical College &
Hospital, Ludhiana, Punjab, IndiaJaspriya SandhuDayanand Medical College &
Hospital, Ludhiana, Punjab, India0000-0002-0323-895Palvi SinglaDayanand Medical College &
Hospital, Ludhiana, Punjab, India0000-0002-2949-7546Aditi BansalDayanand Medical College &
Hospital, Ludhiana, Punjab, Indiahttps://orcid.org/00Bhavna GargDepartment of Pathology, Dayanand
Medical College & Hospital,
Ludhiana, Punjab, IndiaHarpreet KaurDepartment of Pathology, Dayanand
Medical College & Hospital,
Ludhiana, Punjab, IndiaJournal Article20201124Rheumatoid vasculitis, an uncommon extraarticular manifestation<br />of rheumatoid arthritis, usually develops in long-standing cases<br />affecting small-to-medium-sized vessels. It is a poor prognostic<br />marker when multiple systems are affected, skin and neurologic<br />involvement being most frequent. Rheumatoid vasculitis is seen<br />more commonly in seropositive and nodular rheumatoid arthritis<br />patients who are male or smoke. Herein, we present the peculiar<br />case of a 48-year-old female with rapid onset, progressive, multiple<br />ulcers predominantly over the flexures. Differential diagnoses of<br />pyoderma gangrenosum, pyoderma vegetans, pemphigus vegetans,<br />and vasculitis were considered, and the patient was evaluated. On<br />investigation, her rheumatoid factor titer was strongly positive;<br />a skin biopsy revealed leukocytoclastic vasculitis. On clinical,<br />serological, and histopathological correlation, a diagnosis of<br />rheumatoid vasculitis was made, responding well to high-dose<br />prednisolone. On follow-up at six months, her skin lesions had<br />healed well with moderate scarring; however, she developed<br />severe joint pain, warranting the initiation of disease-modifying<br />antirheumatic drugs. To the best of our knowledge, this is a<br />previously unreported clinical and morphological presentation<br />of rheumatoid vasculitis.<br /><br />https://www.iranjd.ir/article_166583_f189505265ec5c94931127cc19905a53.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Toxic epidermal necrolysis-like bullous pemphigoid: a rare case report36737116658410.22034/ijd.2021.265477.1302ENAnil PrakashGosaviDepartment of Dermatology,
Venereology and Leprosy, B. J.
Government Medical College and
Sassoon General Hospital, Pune,
Maharashtra, IndiaRavindranath BrahmadeoChavanDepartment of Dermatology,
Venereology and Leprosy, B. J.
Government Medical College and
Sassoon General Hospital, Pune,
Maharashtra, India0000-0001-6873-0657Neelamkumari BhattDepartment of Dermatology,
Venereology and Leprosy, B. J.
Government Medical College and
Sassoon General Hospital, Pune,
Maharashtra, IndiaNitika DeshmukhDepartment of Dermatology,
Venereology and Leprosy, B. J.
Government Medical College and
Sassoon General Hospital, Pune,
Maharashtra, IndiaDarshana RajendraKundaleDepartment of Dermatology,
Venereology and Leprosy, B. J.
Government Medical College and
Sassoon General Hospital, Pune,
Maharashtra, IndiaJournal Article20210102Bullous pemphigoid is the most common type of subepidermal<br />autoimmune bullous disease. It usually affects older people;<br />isolated cases among people younger than 65 have been reported<br />with various presentations, usually more severe and active than<br />those seen in the elderly. Toxic epidermal necrolysis (TEN) is a<br />potentially life-threatening dermatologic disorder characterized<br />by widespread necrosis and bullous detachment of the epidermis<br />and mucous membranes resulting in exfoliation and possible<br />sepsis. Various morphological variants of bullous pemphigoid<br />have been reported, with reports of the TEN-like variant of<br />bullous pemphigoid being scarce. In this study, we report a case<br />of bullous pemphigoid with TEN-like presentation in a middleaged<br />female.<br /><br />https://www.iranjd.ir/article_166584_0516d04803f4ff8e3a8c856525cebaea.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Serum matrix metalloproteinases in patients with different types of cutis laxa: a case series37237916658510.22034/ijd.2022.355335.1589ENAtieh EbadiSkin Research Center, Shahid
Beheshti University of Medical
Sciences, Tehran, IranFarhad MalekzadSkin Research Center, Shahid
Beheshti University of Medical
Sciences, Tehran, IranMohmmadreza KhorramizadehDepartment of Medical
Biotechnology, Faculty of New
Medical Technology, Tehran
University of Medical Sciences,
Tehran, IranAriana KariminejadKariminejad-Najmabadi Pathology &
Genetic Center, Tehran, IranFahimeh ShahabipourSkin Research Center, Shahid
Beheshti University of Medical
Sciences, Tehran, IranReza MRobatiSkin Research Center, Shahid
Beheshti University of Medical
Sciences, Tehran, IranDepartment of Dermatology,
Loghman Hakim Hospital, Shahid
Beheshti University of Medical
Sciences, Tehran, Iran0000-0002-7947-8642Journal Article20220809Cutis laxa (CL) is a connective tissue disease that<br />is either inherited or acquired. It is characterized by redundant,<br />pendulous, and inelastic skin. Loss of elasticity is a pathological<br />feature of some degenerative and inflammatory diseases. Matrix<br />metalloproteinases (MMPs) can cleave elastin fibers by damaging<br />the microfibrils and the elastin core, resulting in the loss of<br />elasticity.<br />In this study, we report eight patients<br />with different types of cutis laxa along with the quantitative<br />measurement of serum levels of MMP-2 and MMP-9.<br />The cutis laxa patients showed various clinical and<br />histopathological findings, indicating the heterogeneity of this<br />rare skin connective tissue disease. The serum level of MMP-2<br />and MMP-9 were elevated in these patients.<br />Increased MMP-2 and MMP-9 might be associated<br />with cutis laxa. However, our findings need to be validated in<br />larger clinical settings.<br /><br />https://www.iranjd.ir/article_166585_166561b93439ffe9af44f4485de17e18.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201Suction pearl: standardization of syringe suction cup sizes for the three-way cannula-cup device38038216658610.22034/ijd.2020.240168.1168ENMuhammed MukhtarMukhtar Skin Centre, Katihar Medical College Road,
Katihar, India0000-0002-8245-5054Journal Article20200719https://www.iranjd.ir/article_166586_8fa4aa02c9c6dd6b73da4e8cbade9a24.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201An asymptomatic scaly plaque over the glans penis in an elderly male38338516658710.22034/ijd.2022.298126.1414ENVijayasankar PalaniappanDepartment of Dermatology,
Venereology and Leprosy, Sri
Manakula Vinayagar Medical
College and Hospital, Puducherry,
India0000000313314554Premjith RaveendranDepartment of Dermatology,
Venereology and Leprosy, Sri
Manakula Vinayagar Medical
College and Hospital, Puducherry,
IndiaKarthikeyan KaliaperumalDepartment of Dermatology,
Venereology and Leprosy, Sri
Manakula Vinayagar Medical
College and Hospital, Puducherry,
IndiaRamya GandhiDepartment of Pathology, Sri
Manakula Vinayagar Medical
College and Hospital, Puducherry,
IndiaJournal Article20210803https://www.iranjd.ir/article_166587_ca68fcebf6b68a6491645b169e1fbd9c.pdfIranian Society of DermatologyIranian Journal of Dermatology2717-072125420221201A 56-year-old with pustular lesions on extensor areas: what is your diagnosis?38638816658810.22034/ijd.2022.341991.1554ENNasrin SakiDermatology Department, Shiraz
University of Medical Sciences,
Shiraz, Iran
Molecular Dermatology Research
Center, Shiraz University of Medical
Sciences, Shiraz, Iran0000-0002-9795-6898Fatemeh Sari AslaniMolecular Dermatology Research
Center, Shiraz University of Medical
Sciences, Shiraz, IranDepartment of Pathology, School
of Medicine, Shiraz University of
Medical Sciences, Shiraz, Iran0000-0002-6232-9923Mohammad Javad NajafzadehDepartment of Dermatology,
Afzalipour Hospital, Afzalipour
Faculty of Medicine, Kerman
University of Medical Sciences,
Kerman, Iran0000-0001-8974-2358Roya RadanfarDermatology Department, Shiraz
University of Medical Sciences,
Shiraz, Iran0000-0003-0984-4704Seyed Ali HosseiniSchool of Medicine, Shiraz
University of Medical Sciences,
Shiraz, Iran0000-0003-4397-1539Najmeh AhramiyanpourDepartment of Dermatology,
Afzalipour Hospital, Afzalipour
Faculty of Medicine, Kerman
University of Medical Sciences,
Kerman, Iran0000-0003-3171-5933Journal Article20220515https://www.iranjd.ir/article_166588_1799c3b1074438e95135d77412b61801.pdf