Proteus syndrome is a rare congenital disorder comprised of subcutaneous and internal hamartomas, miscellaneous skin and vascular nevi, skeletal and nervous system and eye malformations, with characteristic manifestations including hemihypertrophy, local gigantism, macrodactyly and cerebriform thickness of soles and palms. A 23 year-old man with diagnosis of proteus syndrome had sever anemia due to chronic rectorrhagia due to hemorrhoid. In addition to this problem, he was operated on for atrial septal defect. He also had syndactyly as well as macrodactyly.