Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in patient with AD. The two main pathogenetic characteristic of AD are: I) IgE-mediated antigen dependent “Specific” reactivity, and II) altered non-immunological “Non-specific” reactivity. Because there are no single distinguishing features of AD, the clinical diagnosis is based on a combination of historic and morphologic finding. In this article the immunological aspects in patients with AD will be briefly reviewed.