Cheilitis granulomatosa is a rare disorder of unknown etiology. The condition produces chronic and persistent swelling of one or both lips. The treatment of cheilitis granulomatosa is usually ineffective. Various forms of treatment have been used with variable success. Here I report a 40-year old woman from suburbs of Ahwaz, with persistent swelling of lower lip from 8 months ago, who had not responded to several therapies. She was treated with oral chloroquin 150 mg 3 times a day and topical ointment of Zinc oxide. The swelling of her lip subsided completely after 4 weeks of treatment. In follow up at 6 months, the disease was still in remission.