Cutaneous leishmaniasis may present as unusual manifestations in renal transplant patients receiving immunosuppressive therapy. This misleading presentation, may delay the diagnosis and treatment. Moreover special caution must be taken in renal transplant recipients because of possible interactions between antimony compounds and cyclosporine metabolites. We report a 45-year old man with 5 years history of kidney transplantation receiving immunosuppressive drugs who had an extensive, painful ulcer on the left and upper side of his chest. Laboratory evaluation confirmed the diagnosis of cutaneous leishmaniasis. The patient was treated successfully with a 3-week period of intramuscular Glucantime.