Epidermolysis bullosa are a group of hereditary skin diseases manifested as blisters on the sites of trauma to the skin. According to the level of blister development, epidermolysis bullosa are divided into the following groups: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. The latter two groups are associated with poorer prognosis and higher mortality and morbidity in comparison with the first group due to the mucosal involvement and associated anomalies in other organs. The presented case was a neonate whom was presented with several blisters and erosions on skin since birth as well as clinical findings suggesting stomach outlet obstruction. It is important to evaluate neonates with epidermolysis bullosa for presence of probable associated anomalies.